scholarly journals Hot Water Extract of Mulberry Leaf Ameliorates Hepatic Fat Accumulation and Inflammation in Rats Fed a High-Fat Diet

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 415-415
Author(s):  
Jibin Kim ◽  
Chaemin Kim ◽  
Mak-Soon Lee ◽  
Hyunmi Ko ◽  
Soojin Lee ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Water Extract ◽  
Density Lipoprotein ◽  
Hot Water ◽  
Mrna Levels ◽  
High Fat ◽  
Fat Accumulation ◽  
Mulberry Leaf ◽  
Hot Water Extract ◽  
Hepatic Fat

Abstract Objectives This study was conducted to investigate the effect of mulberry leaf extract on hepatic fat accumulation and inflammation in rats fed a high-fat diet. Methods Male Sprague–Dawley rats were randomly divided into three groups. Each group fed normal diet (NOR), high-fat diet (HF), or HF supplemented with 0.8% (w/w) hot water extract of mulberry leaf (HF + ME) for 14 weeks. Results The mulberry extract (ME) supplementation reduced body weight and white adipose tissues (epididymal, retroperitoneal, and mesenteric) weights. Serum levels of triglyceride (TG), total cholesterol (TC), free fatty acids (FFAs), and low-density lipoprotein cholesterol (LDL-C) were lower, while high-density lipoprotein cholesterol (HDL-C) level was higher in the HF + ME group compared to the HF group. The ME reduced the hepatic total lipid, TG, and TC levels compared to the HF group. The mRNA levels of genes related to fatty acid synthesis, such as CD36, sterol regulatory element binding protein 1c (SREBP-1c), and fatty acid synthase (FAS) were down-regulated by the ME supplementation. In addition, the ME lowered the mRNA levels of pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), compared to the HF group. The serum TNF-α level of the HF + ME group was significantly lower than that of the HF group. Conclusions These results suggested that the ME attenuated high-fat diet-induced hepatic fat accumulation and inflammation via regulating gene expression related to hepatic lipid metabolism and pro-inflammatory mediators. Therefore, it is postulated that the ME might be useful as a functional food ingredient to prevent obesity-induced hepatic fat accumulation and inflammation. Funding Sources None.

scholarly journals Camellia oleifera seed extract attenuated abdominal and hepatic fat accumulation in rats fed a high-fat diet

2019 ◽  
Vol 44 (3) ◽  
pp. 320-325 ◽  
Author(s):  
Hsin-Yi Yang ◽  
Wan-Ju Yeh ◽  
Jung Ko ◽  
Jiun-Rong Chen
Keyword(s):  
High Fat Diet ◽  
Control Diet ◽  
Water Extract ◽  
Liquid Diet ◽  
Hot Water ◽  
Liver Fat ◽  
Camellia Oleifera ◽  
High Fat ◽  
Fat Accumulation ◽  
Hepatic Fat

The objective of this study was to evaluate the effects of the hot-water extract of defatted Camellia oleifera seeds (CSE) on body and liver fat accumulation in rats. Forty rats were divided into 5 groups and each group was fed either an isocaloric control diet or a high-fat liquid diet with 0% (H), 0.12% (H1), 0.24% (H2), or 0.48% CSE (H3) for 8 weeks. Ingestion of the high-fat liquid diet increased abdominal and liver fat accumulation, although no difference was found in body weights compared with rats fed the control diet. We found that rats fed the H2 and H3 diets had lower plasma alanine aminotransferase activities than the H group in the fourth and eighth weeks. At the end of the study, the H2 and H3 groups also had lower epididymal and retroperitoneal fat masses, and all CSE groups had lower circulatory leptin levels than the H group. CSE consumption decreased hepatic fat accumulation in terms of liver triglycerides and a histopathology analysis, and ameliorated high-fat diet-induced elevation of hepatic tumor necrosis factor-α levels. We also found that CSE groups had lower malondialdehyde and hydroxyproline levels in the liver. Our results suggested that CSE may exert beneficial effects through decreasing body fat accumulation and hepatic steatosis and regulating adipokine levels in diet-induced nonalcoholic fatty liver disease.

scholarly journals Ginger Extract Ameliorates Obesity and Inflammation via Regulating MicroRNA-21/132 Expression and AMPK Activation in White Adipose Tissue

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1567 ◽  
Author(s):  
Seunghae Kim ◽  
Mak-Soon Lee ◽  
Sunyoon Jung ◽  
Hye-Yeon Son ◽  
Seonyoung Park ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
High Fat Diet ◽  
Water Extract ◽  
Hot Water ◽  
Root Extract ◽  
Mrna Levels ◽  
Ampk Activation ◽  
High Fat ◽  
Ginger Extract

Ginger is a plant whose rhizome is used as a spice or folk medicine. We aimed to investigate the effect of ginger root extract on obesity and inflammation in rats fed a high-fat diet. Sprague-Dawley rats were divided into three groups and fed either a 45% high-fat diet (HF), HF + hot-water extract of ginger (WEG; 8 g/kg diet), or HF + high-hydrostatic pressure extract of ginger (HPG; 8 g/kg diet) for 10 weeks. The HPG group had lower body weight and white adipose tissue (WAT) mass compared to the HF group. Serum and hepatic lipid levels of HPG group were lower, while fecal lipid excretion of the HPG group was higher than that of the HF group. In the WAT of the WEG and HPG groups, mRNA levels of adipogenic genes were lower than those of the HF group. Moreover, HPG group had lower mRNA levels of pro-inflammatory cytokines than did the HF group. MicroRNA (miR)-21 expression was down-regulated by both WEG and HPG. Additionally, miR-132 expression was down-regulated by HPG. The adenosine monophosphate-activated protein kinase (AMPK) activity of HPG group was greater than that of the HF group. HPG may have beneficial effects on obesity and inflammation, partially mediated by regulation of miR-21/132 expression and AMPK activation in WAT.

Standardized hot water extract from the leaves of Hydrangea serrata (Thunb.) Ser. alleviates obesity via the AMPK pathway and modulation of the gut microbiota composition in high fat diet-induced obese mice

2021 ◽  
Author(s):  
Hee-Soo Han ◽  
Hwi-Ho Lee ◽  
Hyo-Sun Gil ◽  
Kyung-Sook Chung ◽  
Jeon-Kyung Kim ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Water Extract ◽  
Hot Water ◽  
Microbiota Composition ◽  
Obese Mice ◽  
Mtor Signaling Pathway ◽  
High Fat ◽  
Hot Water Extract ◽  
Gut Microbiota Composition

WHS prevented the HFD-induced obesity via regulating AMPK and AKT/mTOR signaling pathway. WHS might be a potential dietary supplement for alleviating obesity.

scholarly journals Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet

2010 ◽  
Vol 17 (Suppl 1) ◽  
pp. S39 ◽  
Author(s):  
Huan Du ◽  
Xu Zhao ◽  
Jeong-Soon You ◽  
Ji-Yeon Park ◽  
Sung-Hoon Kim ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Water Extract ◽  
Hot Water ◽  
Protective Effects ◽  
High Fat ◽  
Taurine Supplementation ◽  
Lotus Root ◽  
Hot Water Extract

scholarly journals Polygonum multiflorum Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice

Plants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1509
Author(s):  
Ra-Yeong Choi ◽  
Mi-Kyung Lee
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
High Fat Diet ◽  
Water Extract ◽  
Hot Water ◽  
Obese Mice ◽  
High Fat ◽  
Polygonum Multiflorum ◽  
Hot Water Extract ◽  
Brown Adipose

The purpose of the present study was to determine whether an anti-obesity effect of a Polygonum multiflorum Thunb. hot water extract (PW) was involved in the lipid metabolism of white adipose tissue (WAT) and brown adipose tissue (BAT) in high-fat diet (HFD)-induced C57BL/6N obese mice. Mice freely received a normal diet (NCD) or an HFD for 12 weeks; HFD-fed mice were orally given PW (100 or 300 mg/kg) or garcinia cambogia (GC, 200 mg/kg) once a day. After 12 weeks, PW (300 mg/kg) or GC significantly alleviated adiposity by reducing body weight, WAT weights, and food efficiency ratio. PW (300 mg/kg) improved hyperinsulinemia and enhanced insulin sensitivity. In addition, PW (300 mg/kg) significantly down-regulated expression of carbohydrate-responsive element-binding protein (ChREBP) and diacylglycerol O-acyltransferase 2 (DGAT2) genes in WAT compared with the untreated HFD group. HFD increased BAT gene levels such as adrenoceptor beta 3 (ADRB3), peroxisome proliferator-activated receptor γ (PPARγ), hormone-sensitive lipase (HSL), cluster of differentiation 36 (CD36), fatty acid-binding protein 4 (FABP4), PPARγ coactivator 1-α (PGC-1α), PPARα, and carnitine palmitoyltransferase 1B (CPT1B) compared with the NCD group; however, PW or GC effectively reversed those levels. These findings suggest that the anti-obesity activity of PW was mediated via suppression of lipogenesis in WAT, leading to the normalization of lipid metabolism in BAT.

scholarly journals Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet

2010 ◽  
Vol 17 (Suppl 1) ◽  
pp. S42 ◽  
Author(s):  
Huan Du ◽  
Jeong-Soon You ◽  
Xu Zhao ◽  
Ji-Yeon Park ◽  
Sung-Hoon Kim ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Water Extract ◽  
Hot Water ◽  
High Fat ◽  
Taurine Supplementation ◽  
Lotus Leaf ◽  
Hot Water Extract

scholarly journals Red Kidney Beans Ameliorate the High Fat Diet-Induced Hepatic Fat Accumulation and Inflammation

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 778-778
Author(s):  
Ibtesam Sleem ◽  
Ashley Toney ◽  
QinYin Shi ◽  
Soonkyu Chung ◽  
Vicki Schlegel
Keyword(s):  
High Fat Diet ◽  
Fatty Acid Synthase ◽  
Liver Weight ◽  
Low Grade ◽  
High Fat ◽  
Gene Expressions ◽  
Fat Accumulation ◽  
Kidney Beans ◽  
Hepatic Fat ◽  
Red Kidney Beans

Abstract Objectives High fat diet (HFD)-induced obesity links with prevalence of metabolic dysfunction, including low-grade chronic inflammation, insulin resistance, and hepatic steatosis. Dry edible beans (DEBs) play a significant role in human nutrition as a rich source of proteins, carbohydrates, fibers, and various micronutrients. The aim of this study is to evaluate the ability of red kidney beans (RKBs) to attenuate the deleterious effects of HFD in the liver. Methods Syrian hamsters were randomly assigned with one of five experimental diet groups; low fat diet (control), high fat diet, high fat diet with 5% whole beans (HFD + B), high fat diet with 4.5% dehulled beans (HFD + DHB) and high fat diet with 0.5% hull of beans (HFD + HB) and fed for 4 weeks. Results Supplementation of RKB resulted in lower body weight, liver weight, and glucose levels (P < 0.001) in HFD + B and HFD + DHB group compared to HFD group. Adding RKBs downregulated gene expressions related to inflammation (e.g., interleukin 6 (IL-6)) and lipogenesis (e.g., hepatic fatty acid synthase (FASN)) in the liver. Furthermore, RKBs supplemented groups showed reduced hepatic fat accumulation in comparison with the HFD group. Conclusions Supplementation of RKBs and their hulls attenuates hepatic stresses by decreasing the lipogenesis and inflammation, which contribute to enhancing insulin sensitivity. Funding Sources USDA Multi-Hatch, Program: W-3150.

scholarly journals Anti-obesity effects of hot water extract from Wasabi (Wasabia japonica Matsum.) leaves in mice fed high-fat diets

2013 ◽  
Vol 7 (4) ◽  
pp. 267 ◽  
Author(s):  
Masayuki Yamasaki ◽  
Tetsuro Ogawa ◽  
Li Wang ◽  
Takuya Katsube ◽  
Yukikazu Yamasaki ◽  
...  
Keyword(s):  
Water Extract ◽  
Hot Water ◽  
High Fat ◽  
Wasabia Japonica ◽  
Hot Water Extract ◽  
High Fat Diets ◽  
Fat Diets
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