Vulvar leiomyosarcoma in a cat

2007 ◽  
Vol 9 (5) ◽  
pp. 435-438 ◽  
Author(s):  
Ibrahim Firat ◽  
Damla Haktanir-Yatkin ◽  
Besim H Sontas ◽  
Hayri Ekici
Keyword(s):  
Smooth Muscle ◽  
Internal Control ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
Spindle Cell Sarcoma ◽  
Vascular Elements ◽  
Collagenous Matrix ◽  
Mixed Breed ◽  
History Of ◽  
Cut Surface

A vulvar leiomyosarcoma was diagnosed in an 8-year-old mixed-breed, sexually intact cat. The cat had a history of vulvar swelling, bleeding and stranguria. The mass was located at the ventral commissura of the vulva. The cut surface of the mass was lobulated and greyish-white, with areas of necrosis and haemorrhage. Histologically, it was a spindle-cell sarcoma consisting of interlacing bundles of very elongated neoplastic smooth muscle cells and variably dense collagenous matrix separated by individual cells or streams. It also contained areas of focal necrosis and haemorrhage. The mitotic index ranged from seven to 12 mitoses per 10 high-power fields. Immunohistochemically, the spindle-shaped neoplastic cells were strongly positive for smooth muscle actin (SMA) and vimentin, whereas no immunoreactivity was obtained for desmin. The vascular elements of the internal control tissue also exhibited strong SMA and vimentin immunoreactivity. Based on the morphological and immunohistochemical features, the tumour was classified as a leiomyosarcoma.

scholarly journals Do GISTs Occur in Rats and Mice? Immunohistochemical Characterization of Gastrointestinal Tumors Diagnosed as Smooth Muscle Tumors in The National Toxicology Program

2019 ◽  
Vol 47 (5) ◽  
pp. 577-584
Author(s):  
Kyathanahalli S. Janardhan ◽  
Priyanka Venkannagari ◽  
Heather Jensen ◽  
Mark J. Hoenerhoff ◽  
Ronald A. Herbert ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cell Morphology ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
Gi Tract ◽  
Toxicological Studies ◽  
Smooth Muscle Tumors ◽  
Hematoxylin And Eosin ◽  
Cells Of Cajal ◽  
Rats And Mice

The majority of the tumors in the gastrointestinal (GI) tract of rats and mice, with spindle cell morphology, are diagnosed as smooth muscle tumors (SMTs). Similarly, several decades ago human GI tumors with spindle cell morphology were also diagnosed as SMTs. However, later investigations identified most of these tumors in humans as gastrointestinal stromal tumors (GISTs). The GISTs are considered to arise from the interstitial cells of Cajal located throughout the GI tract. Positive immunohistochemical staining with CKIT antibody is a well-accepted diagnostic marker for GISTs in humans. Since there is a considerable overlap between the histomorphology of SMTs and GISTs, it is not possible to distinguish them on hematoxylin and eosin stained sections. As a result, GISTs are not routinely diagnosed in toxicological studies. The current study was designed to evaluate the tumors diagnosed as leiomyoma or leiomyosarcoma in the National Toxicology Program’s 2-year bioassays using CKIT, smooth muscle actin, and desmin immunohistochemistry. The results demonstrate that most of the mouse SMTs diagnosed as leiomyoma or leiomyosarcoma are likely GISTs, whereas in rats the tumors are likely SMTs and not GISTs.

Radiographically Occult, Diffuse Intrasinusoidal Hepatic Metastases From Primary Breast Carcinomas: A Clinicopathologic Study of 3 Autopsy Cases

2004 ◽  
Vol 128 (12) ◽  
pp. 1418-1423 ◽  
Author(s):  
Kimberly H. Allison ◽  
Corinne L. Fligner ◽  
W. Tony Parks
Keyword(s):  
Smooth Muscle ◽  
Liver Failure ◽  
Smooth Muscle Actin ◽  
Hepatic Metastases ◽  
Metastatic Carcinoma ◽  
Muscle Actin ◽  
Breast Carcinomas ◽  
Carcinoma Of The Breast ◽  
History Of ◽  
E Cadherin

Abstract Context.—Liver metastases usually present as radiographically detectable mass lesions that do not significantly compromise liver function. Rarely, metastatic carcinoma can diffusely infiltrate hepatic sinusoids, a pattern of metastasis that may be missed on imaging studies, and can result in liver failure. Objective.—To describe the clinicopathologic features of 3 cases of diffuse intrasinusoidal hepatic metastases from primary breast carcinomas identified at autopsy. Design.—Clinical histories and radiographic, macroscopic, and microscopic appearances of the livers were compared. Sampled liver tissue was stained with antibodies to E-cadherin, smooth muscle actin, and CD44. Results.—Two of 3 cases had a history of infiltrating ductal carcinoma of the breast and presented with new-onset liver failure, but no hepatic metastases were identified on radiologic imaging. An additional case had no history of carcinoma, presented with a severe thrombocytopenic thrombotic purpura–like syndrome, and metastatic carcinoma of the breast was diagnosed only at autopsy. The livers in all 3 cases at autopsy were homogeneous, firm, and tan-yellow, and contained no large metastatic lesions. Microscopically, poorly differentiated carcinoma diffusely infiltrated hepatic sinusoids. Antibodies to smooth muscle actin stained activated hepatic stellate cells lining involved sinusoids. Cell surface adhesion molecules, E-cadherin or CD44, were not detected in any hepatic metastases. Conclusion.—Diffuse intrasinusoidal hepatic metastases of breast carcinoma can occupy a large percentage of the hepatic volume, yet remain occult both radiographically and macroscopically. This type of metastatic spread can present as cryptogenic liver failure. The 3 cases we studied were associated with an absence of E-cadherin and CD44 expression.

Interstitial Cells of Cajal in Deep Esophageal Leiomyoma

2016 ◽  
Vol 25 (1) ◽  
pp. 51-53 ◽  
Author(s):  
Magnus Hallin ◽  
Satvinder Mudan ◽  
Khin Thway
Keyword(s):  
Smooth Muscle ◽  
Interstitial Cells Of Cajal ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
Gastroesophageal Junction ◽  
Interstitial Cells ◽  
Correct Treatment ◽  
Mesenchymal Neoplasms ◽  
Spindle Cells ◽  
Cells Of Cajal

Gastrointestinal stromal tumors (GISTs) are potentially aggressive mesenchymal neoplasms with spindle cell, epithelioid, or mixed morphology. They typically express CD117, DOG1, and CD34 and can be diffusely and strongly positive for h-caldesmon. Leiomyomas are benign smooth muscle neoplasms that can arise in a variety of visceral and soft tissue sites, including the gastrointestinal tract. We illustrate a case of a neoplasm of the gastroesophageal junction that was clinically suspected to be a GIST. Histology showed a tumor composed of ovoid and spindle cells arranged in short intersecting fascicles, which was positive for desmin, smooth muscle actin, and h-caldesmon, with a prominent interspersed subpopulation of CD117- and DOG1-positive elongated or dendritic-like cells. These features were of leiomyoma with entrapped interstitial cells of Cajal (ICC). The recognition of possible entrapment of ICC in leiomyomas as a potential mimic of GIST is important for correct treatment and prognostication.

Leiomyosarcoma of the Foot

2007 ◽  
Vol 97 (6) ◽  
pp. 475-479 ◽  
Author(s):  
Erin Engel ◽  
Michael Butler ◽  
Joseph Anain
Keyword(s):  
United States ◽  
Differential Diagnosis ◽  
Malignant Tumor ◽  
Clinical Presentation ◽  
Spindle Cell ◽  
Pyogenic Granuloma ◽  
The United States ◽  
Spindle Cell Sarcoma ◽  
Cell Sarcoma ◽  
History Of

Leiomyosarcoma is a very rare malignant tumor, with only 28 new cases diagnosed in the United States each year. The prognosis varies, with average 5-year survival of 65%. Although most leiomyosarcomas occur in the lower extremity, there is a paucity in the literature on these sarcomas in the foot. Only 15 cases of leiomyosarcoma in the foot have been reported in the literature since the mid-1930s. We describe a 31-year-old man with a history of an ingrown toenail and nonhealing pyogenic granuloma. His clinical presentation suggested atypical tissue. Biopsy findings confirmed the diagnosis of spindle cell sarcoma, specifically, leiomyosarcoma. The patient was treated with amputation of the affected hallux and adjuvant therapy. The similar presentations of a pyogenic granuloma and a malignant tumor necessitate a thorough differential diagnosis with even common foot ailments. (J Am Podiatr Med Assoc 97(6): 475–479, 2007)

scholarly journals Retrobulbar Fibrosarcoma in a Sheep

2016 ◽  
Vol 66 (2) ◽  
pp. 265-270 ◽  
Author(s):  
Ozlem Ozmen ◽  
Ozlem Sirin Sengoz ◽  
Harun Çinar ◽  
Hüseyin Dolu
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Surrounding Tissue ◽  
Nuclear Antigen ◽  
Collagenous Matrix ◽  
Proliferating Cell ◽  
Cut Surface ◽  
Female Sheep ◽  
Pleomorphic Cells

Abstract This report describes a case of a retrobulbar fibrosarcoma in a 4-year-old female sheep. A big tumor was protruding from the orbit but not invading the surrounding tissue and was easily removed surgically. The grayish colored mass was 19×13×8 cm in size and hard. The surface of the tumor was irregular and ulcerated. Marked hemorrhage and necrotic areas were present across the whitish cut surface. Histopathologically, the mass was composed of spindle shaped, anaplastic pleomorphic cells. Masson’s trichrome staining revealed a collagenous matrix in the tissue. Immunohistochemically, the mass was positive for vimentin and proliferating cell nuclear antigen but negative for smooth muscle actin, desmin, glial fibrilar acidic protein and S100 protein antibodies. According to histopathological and immunohistochemical findings the tumor was diagnosed as fibrosarcoma. To the authors’ knowledge, this is the first report of ocular fibrosarcoma in a sheep.

scholarly journals Late-Onset Metastatic Malignant Spindle Cell Tumour Presenting with Massive Intra-Abdominal Haemorrhage

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Pamathy Gnanaselvam ◽  
Malintha Lahiru ◽  
Mariathas Priatharshan ◽  
Umesh Jayarajah ◽  
Kathirvetpillai Kopinath
Keyword(s):  
Spindle Cell ◽  
Late Onset ◽  
Cell Tumour ◽  
Histological Evaluation ◽  
Spindle Cell Sarcoma ◽  
Rare Tumour ◽  
Cell Sarcoma ◽  
Metastatic Deposit ◽  
History Of ◽  
Spindle Cell Tumour

Primary spindle cell sarcoma is a rare tumour. The presentation of acute intra-abdominal bleeding from a metastatic spindle cell tumour has not been previously reported. We report a case of a 40-year-old woman with a history of curative resection of the medial compartment of the right thigh for spindle cell sarcoma presenting with an acute onset abdominal pain and haemorrhagic shock after 5 uneventful years. Emergency exploratory laparotomy was conducted that revealed a retropancreatic mass which had ruptured along its inferior border. Histological evaluation revealed a metastatic deposit of the spindle cell sarcoma. In cases of spontaneous abdominal haemorrhage, it is important to consider the possibility of a ruptured metastatic deposit among the differentials especially in patients with a history of malignancies. Moreover, this is the first reported case of metastatic malignant spindle cell sarcoma presenting with intra-abdominal haemorrhage.

Primary Smooth Muscle Tumor of Breast: An Unusual Case Presentation

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S41-S41
Author(s):  
S Shawn Liu ◽  
Krutika Patel ◽  
Donna Lynn Dyess ◽  
Andrea Kahn
Keyword(s):  
Smooth Muscle ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
Muscle Differentiation ◽  
Malignant Neoplasms ◽  
Imaging Features ◽  
Significant Past Medical History ◽  
Case Presentation ◽  
Spindle Cells ◽  
Smooth Muscle Differentiation

Abstract Introduction Primary smooth muscle tumors (SMT) of the breast are rare with leiomyosarcomas representing less than 0.1% of all malignant breast tumors. Case Presentation A 58-year-old female with no significant past medical history noted on screening mammography to have a circumscribed 6-mm nodule in the right breast, upper outer quadrant. Core needle biopsy showed a spindle cell neoplasm with smooth muscle differentiation. The excisional biopsy showed a 6-mm lesion composed of atypical hyperchromatic spindle cells in fascicles, marked nuclear pleomorphism, and 5 mitoses per 10 high-power fields. By immunohistochemistry, the spindle cells were positive for smooth muscle actin, desmin, and negative for S-100 and cytokeratin AE1/AE3. Positron emission tomography/computed tomography of head/neck, chest, abdomen, and pelvis did not identify other neoplasms. Despite the lesion size, findings were supportive of a leiomyosarcoma. Discussion Breast SMTs have nonspecific clinical or imaging features. Histologically, these present as spindle cell tumors with smooth muscle differentiation. Initial workup starts with distinction between benign and malignant neoplasms. The malignant SMTs are usually large tumors with cytologic atypia and mitotic activity used as diagnostic criteria. In addition, the distinction between primary and metastasis is important and frequently relies on clinical history and exclusion of other primary origins by radiographic survey. In the current case, although the tumor size is unusually small, the histological features and absence of other primary malignancies support the diagnosis of a leiomyosarcoma. Conclusion Primary leiomyosarcoma of breast is extremely uncommon with less than 70 cases reported in the literature. Although they are usually large tumors, this diagnosis should be included in the differential diagnosis when smooth muscle differentiation, significant atypia, and mitoses are encountered in a spindle cell tumor of the breast.

scholarly journals Unique presentation of palatal metastasis from high-grade spindle cell sarcoma of the bone

2020 ◽  
Vol 13 (11) ◽  
pp. e236652
Author(s):  
Valentina Fenech ◽  
Anton Queen ◽  
Archana Gadve ◽  
Fiona Cowie
Keyword(s):  
Soft Palate ◽  
Spindle Cell ◽  
Bone Cancer ◽  
Surgical Excision ◽  
Malignant Tumour ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
History Of ◽  
Primary Bone

Spindle cell sarcoma (SCS) is a rare malignant tumour which can arise in bone and accounts for 2%–5% of primary bone cancer cases. Distant metastasis occurs predominantly in the lungs. However, metastasis to the soft palate, to the best of our knowledge, has never been previously reported. In this case report, we describe a unique presentation of soft palate metastasis in a patient with a history of high-grade SCS of the bone who presented with progressive dysphagia and nausea and vomiting who underwent surgical excision for palliation of symptoms.

scholarly journals A CASE SERIES OF MYOEPITHELIAL CARCINOMA SPINDLE CELL TYPE, CLEAR CELL TYPE, AND PLASMACYTOID TYPE

2017 ◽  
Vol 13 (2) ◽  
pp. 99
Author(s):  
Dian Yuliartha Lestari ◽  
Dyah Fauziah
Keyword(s):  
Smooth Muscle ◽  
Spindle Cell ◽  
Clear Cell ◽  
Smooth Muscle Actin ◽  
Case Series ◽  
Myoepithelial Carcinoma ◽  
Muscle Actin ◽  
Cell Type ◽  
Clear Cell Type ◽  
Spindle Cell Type

Myoepithelial Carcinoma adalah salah satu keganasan kelenjar liur yang sangat jarang terjadi, dimana terdiri dari komponen sel-sel myoepithelial yang berdifferensiasi sebagai sel spindle, sel jernih (clear), sel epitheloid, sel stelate, maupun sel plasmacytoid. Kami melaporkan 3 kasus myoepithelial carcinoma yang didiagnosis di Rumah Sakit Dr. Soetomo Surabaya dalam kurun waktu 4 tahun terakhir dengan tiga tipe yang berbeda, yaitu; spindle cell type, clear cell type, dan plasmacytoid type. Dua kasus terjadi pada kelenjar parotis, lainnya pada kelenjar submandibula, dimana ketiganya terjadi pada wanita dengan rentang usia 45-76 tahun. Keluhan saat datang berobat adalah timbul benjolan semakin membesar secara perlahan dan tidak menimbulkan nyeri. Hasil pemeriksaan histopatologis menyatakan suatu carcinoma mengesankan myoepithelial carcinoma. Hasil pemeriksaan immunohistokimia smooth muscle actin (SMA) dan S100 mayoritas menunjukkan hasil yang positif, dimana menyokong diagnosis suatu myoepithelial carcinoma Kata kunci:  myoepithelial carcinoma, spindle cell type, clear cell type plasmacytoid type

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