scholarly journals IDDF2018-ABS-0129 Effectiveness of rebamipide in the prevention of esophageal stricture formation in advanced corrosive esophagitis: a prospective randomised control study

2018 ◽  
Author(s):  
Mark Lester Sy ◽  
Rei Joseph Prieto ◽  
Alex Pang ◽  
Michael Angelo Chu ◽  
Lovell Gatchalian ◽  
...  
Keyword(s):  
Esophageal Stricture ◽  
Stricture Formation ◽  
Corrosive Esophagitis ◽  
Control Study

A comparative study evaluating the esophageal transit time of eight healthy cats when pilled with the FlavoRx pill glide versus pill delivery treats

2010 ◽  
Vol 12 (4) ◽  
pp. 286-290 ◽  
Author(s):  
Alexander D. Bennett ◽  
Catriona M. MacPhail ◽  
Debra S. Gibbons ◽  
Michael R. Lappin
Keyword(s):  
Comparative Study ◽  
Transit Time ◽  
Esophageal Stricture ◽  
Stricture Formation ◽  
Delivery Method ◽  
Esophageal Transit ◽  
One Step

Retention of tablets or capsules in the feline esophagus can be associated with esophagitis and esophageal stricture formation. The objective of this study was to evaluate the esophageal passage of tablets and capsules when administered with either a one-step pill gun with flavored liquid (FlavoRx pill glide) or a pill delivery treat (Pill Pockets). Four different medication administrations were evaluated on different days in eight normal cats: tablets with FlavoRx pill glide (T-FG), tablets with pill delivery treats (T-PP), capsules with FlavoRx pill glide (C-FG) and capsules with pill delivery treats (C-PP). The estimated average transit time was 36 s for T-FG, 60 s for T-PP, 16 s for C-FG, and 24 s for C-PP. The results of this study suggest that either pill delivery method is acceptable for successful passage of tablets or capsules into the stomach of cats using a single replicate.

scholarly journals A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

2014 ◽  
Vol 52 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Murat Dereli ◽  
Bartlomiej E. Krazinski ◽  
Suleyman Ayvaz ◽  
Burhan Aksu ◽  
Mehmet Kanter ◽  
...  
Keyword(s):  
Esophageal Stricture ◽  
Stricture Formation ◽  
Novel Approach

scholarly journals Prevention Effect of TGF-β Type I Receptor Kinase Inhibitor in Esophageal Stricture Formation after Corrosive Burn

2021 ◽  
Author(s):  
Min Tae Kim ◽  
Kun Yung Kim
Keyword(s):  
Treatment Group ◽  
Esophageal Stricture ◽  
Kinase Inhibitor ◽  
Good Alternative ◽  
Esophageal Stenosis ◽  
Area Ratio ◽  
Control Group ◽  
Stricture Formation ◽  
Type I ◽  
Group A

Corrosive burns lead to progressive esophageal stricture and dysphagia. There are many trials to prevent Esophageal stricture formation after corrosive burn. This study aimed to access the effects of EW-7197 on prevention for esophageal stricture formation after corrosive esophageal burn. animal study were classified divided into three groups: a healthy group, a control group (corrosive burn without EW-7197), and a treatment group (corrosive burn with EW-7197). Corrosive esophageal burns were produced using 30% NaOH on the lower esophagus. For 3 weeks, the control group received vehicle and the treatment group received 20 mg/kg/day EW-7197. Treatment efficacy was assessed by measuring the stenosis ratio by esophagogram with contrast media on day 21. histologic staining was performed to evaluate the fibrosis area ratio, and western blotting was performed to evaluate fibrotic markers. Among 20 rats that underwent surgery, 14 survived. Three in the treatment group died because of esophageal perforation, and three in the control group died due to their debilitating status. The esophageal stenosis ratio was significantly lower in the treatment group than in the control group (12.1 ± 9.5% and 42.2 ± 8.3%, respectively; p = 0.001). The histologic fibrosis area ratio was also significantly lower in the treatment group (12.5 ± 3.0% and 21.6 ± 2.1%, respectively; p = 0.001). The treatment group showed lower expressions of profibrogenic proteins such as TGF-β1, pSmad3, and α-SMA. EW-7197 may be a good alternative for the prevention esophageal stricture formation after corrosive burn.

Mucosal loss as a critical factor in esophageal stricture formation after mucosal resection: a pilot experiment in a porcine model

2019 ◽  
Vol 34 (2) ◽  
pp. 551-556
Author(s):  
Bing-Rong Liu ◽  
Dan Liu ◽  
Wenyi Yang ◽  
Saif Ullah ◽  
Zhen Cao ◽  
...  
Keyword(s):  
Esophageal Stricture ◽  
Porcine Model ◽  
Critical Factor ◽  
Stricture Formation ◽  
Pilot Experiment ◽  
Mucosal Resection

scholarly journals Roles of Steroids in Preventing Esophageal Stricture after Endoscopic Resection

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Yu Qiu ◽  
Ruihua Shi
Keyword(s):  
Endoscopic Resection ◽  
Esophageal Stricture ◽  
Steroid Injection ◽  
Relevant Literature ◽  
Balloon Dilation ◽  
Oral Steroid ◽  
Stricture Formation ◽  
Steroid Administration ◽  
Local Steroid Injection ◽  
Endoscopic Balloon

Background and Purposes. Endoscopic resection has been worldwide recognized as a treatment strategy for early esophageal lesions. The occurrence of esophageal stricture after endoscopic resection will reduce the quality of life of patients. This study will evaluate the efficacy and safety of steroids in the prevention of esophageal stricture after endoscopic resection and the influence of different steroid administration methods.Methods. In the relevant literature database, literature from 2008 to 2018 is retrieved by using preset keywords, the search results are carefully screened, and the conclusion of the literature is synthesized to form arguments and draw conclusions.Results. 73 articles met our requirements. Oral steroid administration, not prophylactic endoscopic balloon dilation alone, was effective in preventing esophagostenosis after esophagoscopic treatment and reducing the number of repeated endoscopic balloon dilations even after extensive endoscopic resection. Local steroid injection is useful and economy for preventing esophageal stricture, even though it may raise the risk of perforation during dilations. A wider range of circumferential mucosal defects is an independent predictor for stricture formation for patents given preventive steroid injections after endoscopic submucosal dissection. For complete circular mucosal defect, the further researches are essential to investigate the role of local steroid injection. The effect of other methods such as steroid gel, intravenous infusion of steroid, and novel steroid filling methods require more confirmation.Conclusions. Therefore, steroids play an irreplaceable role in preventing esophageal stricture after endoscopic resection. Oral and local injections of steroids are the two most acceptable methods and more prospective studies are needed to compare the effectiveness and safety of these two methods.

Predictors of Esophageal Stricture Formation Post-Endoscopic Resection

2012 ◽  
Vol 107 ◽  
pp. S574
Author(s):  
Bashar Qumseya ◽  
Timothy Woodward ◽  
Massimo Raimondo ◽  
Michael Wallace ◽  
Herbert Wolfsen
Keyword(s):  
Endoscopic Resection ◽  
Esophageal Stricture ◽  
Stricture Formation
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