A novel estrogenic compound transformed from fenthion under UV-A irradiation

Background and Aim: Apigenin (API) is an estrogenic compound found in many plants. Sertoli cells reside in the testis and are a key target of environmental toxicants. This study aimed to examine the cytotoxicity, especially oxidative stress of API in mouse Sertoli TM4 cells. Materials and Methods: Mouse Sertoli TM4 cells were treated with 50 and 100 μM API for 48 h. Cell viability, lactate dehydrogenase (LDH) activities, glutathione reductase (GR) activities, production of reactive oxygen species (ROS), and malondialdehyde (MDA) levels were evaluated using various assays. Results: Treatment with API at both 50 and 100 μM decreased viability and GR activity but increased LDH activity, ROS production, and MDA levels in mouse Sertoli TM4 cells. Conclusion: Exposure to API induced oxidative stress in mouse Sertoli TM4 cells.

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The Coordinated P53 and Estrogen Receptor Cis-Regulation at an FLT1 Promoter SNP Is Specific to Genotoxic Stress and Estrogenic Compound

PLoS ONE ◽

10.1371/journal.pone.0010236 ◽

2010 ◽

Vol 5 (4) ◽

pp. e10236 ◽

Cited By ~ 18

Author(s):

Yari Ciribilli ◽

Virginia Andreotti ◽

Daniel Menendez ◽

Jan-Stephan Langen ◽

Gilbert Schoenfelder ◽

...

Keyword(s):

Estrogen Receptor ◽

Genotoxic Stress ◽

Estrogenic Compound ◽

Cis Regulation

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Improving Estrogenic Compound Screening Efficiency by Using Self-Modulating, Continuously Bioluminescent Human Cell Bioreporters Expressing a Synthetic Luciferase

Toxicological Sciences ◽

10.1093/toxsci/kfz004 ◽

2019 ◽

Vol 168 (2) ◽

pp. 551-560 ◽

Cited By ~ 2

Author(s):

Tingting Xu ◽

Andrew Kirkpatrick ◽

Jody Toperzer ◽

Steven Ripp ◽

Dan Close

Keyword(s):

Human Cell ◽

Estrogenic Compound ◽

Compound Screening ◽

Screening Efficiency

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Migration of nonylphenols from polymer packaging materials into food simulants

Czech Journal of Food Sciences ◽

10.17221/152/2008-cjfs ◽

2009 ◽

Vol 27 (No. 4) ◽

pp. 293-299 ◽

Cited By ~ 12

Author(s):

L. Votavová ◽

J. Dobiáš ◽

M. Voldřich ◽

H. Čížková

Keyword(s):

Food Packaging ◽

Acetic Acid Solution ◽

Industrial Applications ◽

Packaging Materials ◽

Distilled Water ◽

Detection Level ◽

Estrogenic Compound ◽

Food Simulants ◽

Safety Risks ◽

Potential Safety

<I>p</I>-Nonylphenol (NP) is widely used in many industrial applications (detergents, latex paints, pesticides, and plastics), and its presence in the environment has acquired an increasing concern since it was shown to be, besides its persistence and toxicity, an estrogenic compound. Seven samples of stretch PVC films and two PVC dishes for food packaging obtained from food producers were analysed for the presence of NP. Four of the PVC films contained NP at the concentrations of 0.44 mg/g, 1.03 mg/g, 1.28 mg/g, and 1.72 mg/g, respectively, while NP was not detected (the detection level being 5 μg/g) in the remaining films and two dishes. The NP positive films were used for the studies of NP migration into the food simulants. The levels of NP migration into the food simulants: distilled water, 3% acetic acid solution, and 95% ethanol were 0.017– 0.091 mg/g (3.2–5.3%), 0.013–0.079 mg/g (2.9–4.6%), and 0.125–0.449 mg/g (21.5–35.0%), respectively. The potential safety risks estimated from the results obtained as well as the possible sources of the NP contamination in the analysed stretch PVC food films are discussed in the following article.

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