Multi-Omics Analysis to Reveal Disorders of Cell Metabolism and Integrin Signaling Pathways induced by PM2.5

2021 ◽  
pp. 127573
Author(s):  
Xiaoyao Song ◽  
Jianhui Liu ◽  
Ningbo Geng ◽  
Yichu Shan ◽  
Baoqin Zhang ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Cell Metabolism ◽  
Integrin Signaling ◽  
Omics Analysis

scholarly journals Ragulator—a multifaceted regulator of lysosomal signaling and trafficking

2017 ◽  
Vol 216 (12) ◽  
pp. 3895-3898 ◽  
Author(s):  
Alexandria Colaço ◽  
Marja Jäättelä
Keyword(s):  
Growth Factor ◽  
Signaling Pathways ◽  
Nutrient Availability ◽  
Cell Metabolism ◽  
Metabolic Signaling ◽  
Lysosomal Trafficking ◽  
Cell Biol

The lysosomal Ragulator complex regulates cell metabolism and growth by coordinating the activities of metabolic signaling pathways with nutrient availability. In this issue, Filipek et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703061) and Pu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703094) introduce a role for Ragulator in growth factor– and nutrient-regulated lysosomal trafficking.

scholarly journals Epithelial to Mesenchymal Transition and Cell Biology of Molecular Regulation in Endometrial Carcinogenesis

2019 ◽  
Vol 8 (4) ◽  
pp. 439 ◽  
Author(s):  
Hsiao-Chen Chiu ◽  
Chia-Jung Li ◽  
Giou-Teng Yiang ◽  
Andy Tsai ◽  
Meng-Yu Wu
Keyword(s):  
Growth Factor ◽  
Signaling Pathways ◽  
Cell Biology ◽  
Epithelial To Mesenchymal Transition ◽  
Epithelial Mesenchymal Transition ◽  
Cell Metabolism ◽  
Basic Research ◽  
Genetic Mutation ◽  
Molecular Regulation ◽  
Mesenchymal Transition

Endometrial carcinogenesis is involved in several signaling pathways and it comprises multiple steps. The four major signaling pathways—PI3K/AKT, Ras/Raf/MEK/ERK, WNT/β-catenin, and vascular endothelial growth factor (VEGF)—are involved in tumor cell metabolism, growth, proliferation, survival, and angiogenesis. The genetic mutation and germline mitochondrial DNA mutations also impair cell proliferation, anti-apoptosis signaling, and epithelial–mesenchymal transition by several transcription factors, leading to endometrial carcinogenesis and distant metastasis. The PI3K/AKT pathway activates the ransforming growth factor beta (TGF-β)-mediated endothelial-to-mesenchymal transition (EMT) and it interacts with downstream signals to upregulate EMT-associated factors. Estrogen and progesterone signaling in EMT also play key roles in the prognosis of endometrial carcinogenesis. In this review article, we summarize the current clinical and basic research efforts regarding the detailed molecular regulation in endometrial carcinogenesis, especially in EMT, to provide novel targets for further anti-carcinogenesis treatment.

scholarly journals Procyanidin B2 3,3″-di-O-gallate Inhibits Endothelial Cells Growth and Motility by Targeting VEGFR2 and Integrin Signaling Pathways

2015 ◽  
Vol 15 (1) ◽  
pp. 14-26 ◽  
Author(s):  
Rahul Kumar ◽  
Gagan Deep ◽  
Michael Wempe ◽  
Rajesh Agarwal ◽  
Chapla Agarwal
Keyword(s):  
Endothelial Cells ◽  
Signaling Pathways ◽  
Integrin Signaling

scholarly journals IL-10 and integrin signaling pathways are associated with head and neck cancer progression

BMC Genomics ◽  
2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Sophia Bornstein ◽  
Mark Schmidt ◽  
Gabrielle Choonoo ◽  
Trevor Levin ◽  
Joe Gray ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Signaling Pathways ◽  
Cancer Progression ◽  
Neck Cancer ◽  
Integrin Signaling

scholarly journals Crosstalk between hepatocyte growth factor and integrin signaling pathways

2006 ◽  
Vol 13 (2) ◽  
pp. 215-223 ◽  
Author(s):  
Po-Chao Chan ◽  
Shu-Yi Chen ◽  
Chun-Hwa Chen ◽  
Hong-Chen Chen
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Signaling Pathways ◽  
Integrin Signaling ◽  
Hepatocyte Growth

scholarly journals CYLD Inhibits Melanoma Growth and Progression through Suppression of the JNK/AP-1 and β1-Integrin Signaling Pathways

2013 ◽  
Vol 133 (1) ◽  
pp. 221-229 ◽  
Author(s):  
Hengning Ke ◽  
Christina K. Augustine ◽  
Vineela D. Gandham ◽  
Jane Y. Jin ◽  
Douglas S. Tyler ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Integrin Signaling ◽  
Β1 Integrin ◽  
Melanoma Growth
Sign in / Sign up

Export Citation Format

Share Document