scholarly journals LB778 A quantitative scoring system for cutaneous immune-related adverse events

2021 ◽  
Vol 141 (9) ◽  
pp. B17
Author(s):  
N.I. Hornick ◽  
M. Damo ◽  
J. Leventhal ◽  
N. Joshi
Author(s):  
Faeze Salahshour ◽  
Mohammad-Mehdi Mehrabinejad ◽  
Mohssen Nassiri Toosi ◽  
Masoumeh Gity ◽  
Hossein Ghanaati ◽  
...  

2009 ◽  
Vol 43 (3) ◽  
pp. 244 ◽  
Author(s):  
Kyung Jin Seo ◽  
Tae-Jung Kim ◽  
Kyo-Young Lee ◽  
Sang In Shim ◽  
Yeong-Jin Choi

Author(s):  
Alda Troncone ◽  
Antonietta Chianese ◽  
Alfonso Di Leva ◽  
Maddalena Grasso ◽  
Crescenzo Cascella

Abstract To assess the psychometric properties of the Draw a Person: A Quantitative Scoring System (DAP:QSS), in 2543 children (M = 11.43 ± 3.06 years), correlations between drawings scores and Raven’s Matrices scores, age, and academic achievement were examined. Although older children (> 11 years) obtained higher drawing scores than younger ones (p < 0.001), age significantly correlated with DAP:QSS scores only in children younger than 11 years (r = 0.493, p < 0.001), indicating conflictive evidence for construct validity and a possible ceiling effect. No correlations emerged between DAP:QSS scores and grades (r = 0.056, p = 0.097). DAP:QSS scores were significantly associated with Raven’s Matrices score, but low correlation coefficients (0.156–0.498), low sensitivity (0.12), and high false negative (87.9%) and positive (82%) rates suggest poor DAP:QSS validity as an intelligence measure. The researchers concluded that DAP:QSS failed to produce a psychometrically sound assessment of children’s intellectual functioning.


Materials ◽  
2020 ◽  
Vol 13 (7) ◽  
pp. 1519
Author(s):  
Therese Bormann ◽  
Sebastian Jäger ◽  
J. Philippe Kretzer ◽  
Laura Nebel ◽  
Lucas Clarius ◽  
...  

Frequently occurring damage, as well as elevated blood metal ion levels, are reported in relation to a tumor and revision system for total knee arthroplasty (TKA), which applies a rotating hinge coupling with a metal-on-metal (MoM) articulation. As the patient collective for this specific system is small, there is no data on wear generated from the couplings. In this study, wear volume and influencing parameters were investigated at 44 retrieved TKAs with MoM couplings. A scoring system rating frequently occurring abrasive wear between 0 (no wear) and 3 (distinct wear) was established. The wear score was correlated to time in vivo, bone resection length, patient weight and polyethylene inlay damage. Volumetric wear was estimated applying coordinate measurements. An elevated wear score of two or higher was found in 43% of cases. The mean wear rate accounted to 7.8 mm3/year. The main influencing coefficient for the extent of wear is time in vivo. We found a tendency for higher wear scores with higher inlay degradation scores. Patient weight and bone resection length did not impact coupling wear. Assessment of wear damage by a semi-quantitative scoring system has proven to be a reliable option for non-destructive coupling evaluation. The generated wear volume is high.


2010 ◽  
Vol 65 (2) ◽  
pp. 93-94
Author(s):  
Srinivas Kondalsamy-Chennakesavan ◽  
Chantal Bouman ◽  
Suzanne De Jong ◽  
Karen Sanday ◽  
Jim Nicklin ◽  
...  

2009 ◽  
Vol 115 (3) ◽  
pp. 329-333 ◽  
Author(s):  
Srinivas Kondalsamy-Chennakesavan ◽  
Chantal Bouman ◽  
Suzanne De Jong ◽  
Karen Sanday ◽  
Jim Nicklin ◽  
...  

2020 ◽  
Vol 33 (5) ◽  
pp. 674-679
Author(s):  
Feifei Zhou ◽  
Shuyang Li ◽  
Yanbin Zhao ◽  
Yilong Zhang ◽  
Kevin L. Ju ◽  
...  

OBJECTIVEThe authors aimed to identify factors that may be useful for quantifying the amount of degenerative change in preoperative patients to identify ideal candidates for cervical disc replacement (CDR) in patients with a minimum of 10 years of follow-up data.METHODSDuring the period from December 2003 to August 2008, 54 patients underwent CDR with a Bryan cervical disc prosthesis performed by the same group of surgeons, and all of the patients in this group with at least 10 years of follow-up data were enrolled in this retrospective analysis of cases. Postoperative bone formation was graded in radiographic images by using the McAfee classification for heterotopic ossification. Preoperative degeneration was evaluated in radiographs based on a quantitative scoring system. After univariate analysis, the authors performed multifactor logistic regression analysis to identify significant factors. To determine the cutoff points for the significant factors, a receiver operating characteristic (ROC) curve analysis was conducted.RESULTSStudy patients had a mean age of 43.6 years and an average follow-up period of 120.3 months. The patients as a group had a 68.2% overall incidence of bone formation. Based on univariate analysis results, data for patient sex, disc height, and the presence of anterior osteophytes and endplate sclerosis were included in the multivariate analysis. According to the analysis results, the identified independent risk factors for postoperative bone formation included disc height, the presence of anterior osteophytes, and endplate sclerosis, and according to a quantitative scoring system for degeneration of the cervical spine based on these variables, the ROC curve indicated that the optimal cutoff scores for these risk factors were 0.5, 1.5, and 1.5, respectively.CONCLUSIONSAmong the patients who were followed up for at least 10 years after CDR, the incidence of postoperative bone formation was relatively high. The study results indicate that the degree of degeneration in the target level before surgery has a positive correlation with the incidence of postoperative ossification. Rigorous indication criteria for postoperative ossification should be applied in patients for whom CDR may be a treatment option.


2020 ◽  
Author(s):  
Xenofon Baraliakos ◽  
Philipp Sewerin ◽  
Eugenio de Miguel ◽  
Effie Pournara ◽  
Christine Kleinmond ◽  
...  

Abstract Background: The currently available scoring methods for enthesitis are often measures of pain but not of inflammation at entheseal sites. The Outcome Measures in Rheumatology Clinical Trials (OMERACT) psoriatic arthritis (PsA) magnetic resonance imaging (MRI) scoring system (PsAMRIS) assesses inflammation and damage in PsA and was particularly developed for the hands. The ACHILLES trial used clinical measures for heel enthesitis in combination with MRI scoring based on PsAMRIS.Methods: Patients (age ≥ 18 years) with spondyloarthritis (SpA) and PsA were included in the trial if they presented with clinical and MRI-positive heel enthesitis. MRI of the affected heel was performed at three time points: screening, Week 24 and Week 52. Inflammatory MRI findings (tendinitis, bursitis and bone marrow oedema [BME]) in the area of the Achilles tendon and/or plantar aponeurosis, periarticular inflammation of the ankle joint and heel erosion were assessed qualitatively (absent/present). In addition, BME and bone erosion were quantitatively assessed based on PsAMRIS, where their proportion was compared to the volume of the affected bone. Mean scores of BME and bone erosion quantification were calculated, and the mean composite score (based on PsAMRIS) was calculated based on the individual score of each subject for periarticular inflammation, BME and bone erosion and further extended for bursitis and tendinitis. Modifications to PsAMRIS were introduced by categorising oedema length as ≤/> 0.5 cm and locating bone erosion.Conclusions: In ACHILLES, MRI was used to assess and evaluate heel enthesitis. Due to the lack of a validated scoring system for heel enthesitis at the time of ACHILLES initiation, this trial applied quantitative scoring based on PsAMRIS, with specific adaptations for the heel.Trial registration: National Clinical Trial Registry, NCT02771210. Registered 13 May 2016. https://clinicaltrials.gov/ct2/show/NCT02771210?term=NCT02771210&draw=2&rank=1


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