scholarly journals Increased CD5+ B-cells are associated with autoimmune phenomena in lepromatous leprosy patients

2019 ◽  
Vol 12 (5) ◽  
pp. 656-659
Author(s):  
Attia Kotb ◽  
Samia Ismail ◽  
Itoh Kimito ◽  
Waghi Mohamed ◽  
Alamery Salman ◽  
...  
Keyword(s):  
B Cells ◽  
Lepromatous Leprosy ◽  
Leprosy Patients ◽  
Autoimmune Phenomena

Unusual non-trophic ulcerations in leprosy: A case series of 17 patients

2021 ◽  
pp. 004947552199849
Author(s):  
Prakriti Shukla ◽  
Kiran Preet Malhotra ◽  
Parul Verma ◽  
Swastika Suvirya ◽  
Abir Saraswat ◽  
...  
Keyword(s):  
Erythema Nodosum ◽  
Case Series ◽  
Lepromatous Leprosy ◽  
Sweet Syndrome ◽  
Erythema Nodosum Leprosum ◽  
Leprosy Patients ◽  
Atypical Presentations ◽  
Neuropathic Ulcers

Non-neuropathic ulcers in leprosy patients are infrequently seen, and atypical presentations are prone to misdiagnosis. We evaluated diagnosed cases of leprosy between January 2017 and January 2020 for the presence of cutaneous ulceration, Ridley–Jopling subtype of leprosy, reactions and histologic features of these ulcerations. Treatment was given as WHO recommended multi-bacillary multi-drug therapy. We found 17/386 leprosy patients with non-neuropathic ulcers. We describe three causes – spontaneous cutaneous ulceration in lepromatous leprosy (one nodular and one diffuse), lepra reactions (five patients with type 1; nine with type 2, further categorised into ulcerated Sweet syndrome-like who also had pseudoepitheliomatous hyperplasia, pustulo-necrotic and necrotic erythema nodosum leprosum) and Lucio phenomenon (one patient). Our series draws attention towards the different faces of non-neuropathic ulcers in leprosy, including some atypical and novel presentations.

HLA-DQ molecules and the control ofMycobacterium leprae-specific T cell nonresponsiveness in lepromatous leprosy patients

1990 ◽  
Vol 20 (10) ◽  
pp. 2347-2350 ◽  
Author(s):  
Tom H. M. Ottenhoff ◽  
Charlotte Walford ◽  
Yasuharu Nishimura ◽  
N. B. B. Reddy ◽  
Takehiko Sasazuki
Keyword(s):  
T Cell ◽  
Lepromatous Leprosy ◽  
Hla Dq ◽  
Leprosy Patients

scholarly journals Clinical variables associated with disability in leprosy cases in northeast Brazil

2015 ◽  
Vol 9 (03) ◽  
pp. 232-238 ◽  
Author(s):  
Victor Santana Santos ◽  
Andressa Mayara Santos de Matos ◽  
Lorena Sheila Alves de Oliveira ◽  
Ligia Mara Dolce de Lemos ◽  
Ricardo Queiroz Gurgel ◽  
...  
Keyword(s):  
Physical Disability ◽  
Lepromatous Leprosy ◽  
Northeast Brazil ◽  
Chi Square ◽  
Factors Associated ◽  
Operational Classification ◽  
Leprosy Patients ◽  
Chi Square Test ◽  
Multibacillary Leprosy ◽  
Significant Factors

Introduction: The clinical outcomes of leprosy include complications such as physical disabilities and deformities that vary according to the degree of impairment of nerve trunks. Knowledge of the factors that lead to the development of these complications is important for disability prevention programs. This study aimed to evaluate clinical factors associated with the occurrence of physical disability in leprosy cases. Methodology: This was a retrospective study of 2,358 cases of leprosy in Aracaju, northeast Brazil, between 2001 and 2011. Analysis was done using the Chi-square test and logistic regression model. Results: Significant factors associated with disability were found to be male gender, having more than two affected nerves, multibacillary leprosy classification, leprosy reaction, and lepromatous leprosy. The multivariate analysis revealed that the associated factors included having more than two affected nerves, leprosy reaction (adjusted odds ratio [aOR]: 2.02, 95% confidence interval [CI]: 1.36 to 3.01), the multibacillary form (aOR: 2.74, 95% CI: 1.84 to 4.08), and lepromatous leprosy (aOR: 4.87, 95% CI: 2.86 to 16.08). Conclusions: The number of affected nerves, leprosy reaction, operational classification, and clinical presentation were identified as the main factors associated with the development of disability in leprosy patients.

Recovery of IFN-γ levels in PBMCs from lepromatous leprosy patients through the synergistic actions of the cytokines IL-12 and IL-18

2008 ◽  
Vol 8 (13-14) ◽  
pp. 1715-1720 ◽  
Author(s):  
Rocio Ivette Lopez Roa ◽  
Celia Guerrero Velásquez ◽  
Anabell Alvarado Navarro ◽  
Margarita Montoya Buelna ◽  
Cesar Garcia Niebla ◽  
...  
Keyword(s):  
Lepromatous Leprosy ◽  
Leprosy Patients ◽  
Ifn Γ

scholarly journals Lsr2 Peptides of Mycobacterium leprae Show Hierarchical Responses in Lymphoproliferative Assays, with Selective Recognition by Patients with Anergic Lepromatous Leprosy

2011 ◽  
Vol 80 (2) ◽  
pp. 742-752 ◽  
Author(s):  
Mehervani Chaduvula ◽  
A. Murtaza ◽  
Namita Misra ◽  
N. P. Shankar Narayan ◽  
V. Ramesh ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Mycobacterium Leprae ◽  
Lepromatous Leprosy ◽  
Healthy Controls ◽  
Content Type ◽  
Tuberculosis Patients ◽  
Cell Responses ◽  
Leprosy Patients

ABSTRACTLsr2 protein ofMycobacterium lepraewas shown earlier to elicit B and T cell responses in leprosy patients (20, 28). Lymphoproliferation toM. lepraeand Lsr2 antigens was observed in >70% of tuberculoid (T) patients and in 16 and 34% of lepromatous (L) patients, respectively. We focused on theM. lepraenonresponders in the lepromatous group using 22 synthetic Lsr2 peptides (end-to-end peptides A to F and overlapping peptides p1 to p16) inin vitroT cell responses. A total of 125 leprosy and 13 tuberculosis patients and 19 healthy controls from the area of endemicity (here, healthy controls, or HC) were investigated. The highest responses were observed (67 to 100%) in HC for all peptides except p1 to p3, and the lowest was observed in tuberculosis patients. Significant differences in lymphoproliferation were observed in T, L, and HC groups (analysis of variance [ANOVA],P= 0.000 to 0.015) for all end-to-end peptides except B and for p5 and p7 to p10. Hierarchical recognition between lepromatous and tuberculoid leprosy was noted for p8 (P< 0.05) and between the HC and L groups for p7 to p10, p15, and p16 (P< 0.005 toP< 0.02). Significant lymphoproliferation was observed to peptides A to F and p1 to p9, p11, p12, p15, p16 (P= 0.000 to 0.001) with 40% responding to peptides C and p16 in L patients. Lepromatous patients also showed significantly higher levels of a gamma interferon (IFN-γ) response to peptide C than to other peptides (P< 0.05). Major histocompatibility complex (MHC) class II bias for peptide recognition was not observed. These studies indicate that Lsr2 has multiple T cell epitopes that inducein vitroT cell responses in the highly infective lepromatous leprosy patients.

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