Age-related mechanical strength evolution of trabecular bone under fatigue damage for both genders: Fracture risk evaluation

2018 ◽  
Vol 84 ◽  
pp. 64-73 ◽  
Author(s):  
Rabeb Ben Kahla ◽  
Abdelwahed Barkaoui ◽  
Tarek Merzouki
Keyword(s):  
Fracture Risk ◽  
Mechanical Strength ◽  
Trabecular Bone ◽  
Fatigue Damage ◽  
Risk Evaluation ◽  
Age Related ◽  
Strength Evolution

Trabecular Bone Score in Thais with or without Type 2 Diabetes

2020 ◽  
Vol 103 (11) ◽  
pp. 1131-1137
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fracture Risk ◽  
Trabecular Bone ◽  
Trabecular Bone Score ◽  
Mineral Density ◽  
Men And Women

Background: When compared to people without type 2 diabetes mellitus (T2DM), people with T2DM have an increase in fracture risk despite having higher bone mineral density (BMD). Many studies in Caucasians demonstrated that trabecular bone score (TBS) is lower in people with T2DM than those without. The utility of TBS as a fracture risk assessment tool in Asians with T2DM is currently unclear. Objective: To compared lumbar spine (LS) BMD and TBS in Thais with or without T2DM and investigate the correlation between TBS and hemoglobin A1c (HbA1c) and diabetes duration in participants with T2DM. Materials and Methods: The present study was a cross-sectional study that included 97 participants with T2DM (37 men and 60 women) and 342 participants without T2DM (174 men and 168 women). LS-BMD and TBS were obtained. Results: Men and women with T2DM were older and had higher body mass index (BMI). Men with T2DM had significant higher LS-BMD (1.051±0.166 versus 0.972±0.125, p=0.009) and non-significant lower TBS (1.333±0.084 versus 1.365±0.096, p=0.055) than those without. Similarly, women with T2DM had significant higher LS-BMD (0.995±0.155 versus 0.949±0.124, p=0.021) and lower TBS (1.292±0.105 versus 1.382±0.096, p<0.001). After adjusting for age and BMI, T2DM predicted higher BMD in men (p<0.001), but not in women (p=0.143). T2DM was not associated with TBS after adjusting for age and BMI in both genders (p=0.403 and p=0.151 in men and women, respectively). TBS did not correlate with HbA1c in both genders. However, TBS was non-significantly associated with diabetes duration in women (p=0.073), but not in men (p=0.639). Conclusion: T2DM significantly predicted higher LS-BMD only in men and was not independently associated with TBS in both genders. These data highlighted that, in T2DM, there was some variation in the clinical usefulness of BMD and TBS in predicting osteoporotic fractures with regard to clinical characteristic of participants. Keywords: Bone mineral density, Type 2 diabetes mellitus, Trabecular bone score

Age-related changes in resorption cavity characteristics in human trabecular bone

1991 ◽  
Vol 1 (4) ◽  
pp. 257-261 ◽  
Author(s):  
P. I. Croucher ◽  
N. J. Garrahan ◽  
R. W. E. Mellish ◽  
Juliette E. Compston
Keyword(s):  
Trabecular Bone ◽  
Human Trabecular Bone ◽  
Age Related ◽  
Cavity Characteristics ◽  
Age Related Changes

Devising global strategies for fracture-risk evaluation

2007 ◽  
Vol 74 (3) ◽  
pp. 240-244 ◽  
Author(s):  
Patricia Dargent-Molina ◽  
Claude-Laurent Benhamou ◽  
Bernard Cortet ◽  
Bruno Sutter ◽  
Thierry Thomas
Keyword(s):  
Fracture Risk ◽  
Risk Evaluation ◽  
Global Strategies

An Improved In Vivo Rat Tail Vertebra Model for the Study of Trabecular Bone Adaptation

1999 ◽  
Author(s):  
Mark J. Eichler ◽  
Chi Hyun Kim ◽  
X. Edward Guo
Keyword(s):  
Trabecular Bone ◽  
Large Scale ◽  
Bone Fractures ◽  
Mechanical Load ◽  
Bone Adaptation ◽  
Surgical Trauma ◽  
Micro Computed Tomography ◽  
Age Related ◽  
Rat Tail

Abstract The role of mechanical loading in trabecular bone adaptation is important for the understanding of bone integrity in different loading scenarios such as microgravity and for the etiology of age-related bone fractures. There have been numerous in vivo animal studies of bone adaptation, most of which are related to cortical bone remodeling, aimed at the investigation of Wolff’s Law [4], An interesting experimental model for trabecular bone adaptation has been developed in the rat tail vertebrae [2,3]. This model is attractive for trabecular bone adaptation studies because a controlled mechanical load can be applied to a whole vertebra with minimal surgical trauma, using a relatively inexpensive animal model. In addition, with advanced micro computed tomography (micro-CT) or micro magnetic resonance imaging (micro-MRI) coupled with large scale finite element modeling techniques, it is possible to characterize the three-dimensional (3D) stress/strain environment in the bone tissue close to a cellular level (∼25μm) [1]. Therefore, this in vivo rat tail model has a tremendous potential for quantification of the relationship between mechanical stimulation and biological response in trabecular bone adaptation.

scholarly journals Role of disc area and trabecular bone density on lumbar spinal column fracture risk curves under vertical impact

2018 ◽  
Vol 72 ◽  
pp. 90-98 ◽  
Author(s):  
Narayan Yoganandan ◽  
Jason Moore ◽  
Frank A. Pintar ◽  
Anjishnu Banerjee ◽  
Nicholas DeVogel ◽  
...  
Keyword(s):  
Bone Density ◽  
Fracture Risk ◽  
Trabecular Bone ◽  
Spinal Column ◽  
Trabecular Bone Density ◽  
Disc Area ◽  
Lumbar Spinal ◽  
Risk Curves ◽  
Vertical Impact

Prediction of the Absence of Brittle Failure Risk for Ferritic Steel Piping Components in the Brittle-Ductile Region

2011 ◽  
Author(s):  
S. Marie ◽  
J. Schwab ◽  
S. Vidard
Keyword(s):  
Brittle Fracture ◽  
Fracture Risk ◽  
Brittle Failure ◽  
Risk Evaluation ◽  
Critical Stress ◽  
Ferritic Steel ◽  
Loading Condition ◽  
Maximum Principal Stress ◽  
Fracture Transition ◽  
Secondary Loop

This paper deals with the brittle fracture risk evaluation for a C-Mn piping component in the upper shelf of the brittle to ductile fracture transition temperature range, with the main objective to validate a predictive criteria, able to demonstrate the complete absence of brittle fracture risk. The criteria is based one a critical stress and the volume around the crack were the maximum principal stress exceed this critical stress. The model is calibrated on notched tensile specimens and CT specimens. A four-points bending pipe test has then been designed using this criterion to insure that no brittle fracture will occurs at a temperature that all CT specimens failed by cleavage. The material is a French secondary loop Tu42C ferritic steel and the pipe dimensions for the test are the same than the size of the principal secondary loop pipes. The results of the pipe test confirm the prediction with the model and the interpretation lead to define an equivalence between the loading conditions (based on the J parameter) of the pipe and the loading condition of a CT specimen.

scholarly journals Age Related Lumbar Trabecular Bone in a Thai Population

2021 ◽  
Vol 20 (3) ◽  
Author(s):  
Pornpath Sattarath ◽  
Kittichai Wantanajittikul ◽  
Sukon Prasitwattanaseree ◽  
Jongkolnee Settakorn ◽  
Karnda Mekjaidee
Keyword(s):  
Trabecular Bone ◽  
Negative Correlation ◽  
Spinal Column ◽  
Lumbar Vertebrae ◽  
Processing Technique ◽  
Image Processing Technique ◽  
Female Group ◽  
Thai Population ◽  
Age Related ◽  
The Individual

Within spinal column, the lumbar vertebrae are the most durable and usually left behind in severely burnt body. European studies have reported that these vertebrae are useful for age estimation. However, it is widely acknowledged that different ancestry necessitates different methods and includes a range of variables, therefore a study specific to Thai population is needed for accuracy in the identification of Thai individuals. To investigate the correlation between lumbar vertebrae, and age of the individual, L1-L5 drilled out from 75 Thai cadavers. After undergoing histological processing each slide was photographed. The images were processed using an image processing technique to calculate the percentage of trabecular bone area over total area (%TBA/TA). Using the Statistical Package for the Social Sciences (SPSS) program, %TBA/TA of L1-L5 was calculated. The %TBA/TA of L1-L5 showed a negative correlation to age in both male and female groups. The %TBA/TA of L2 in the male group decreased most significantly with increase in age (r=-0.775) whereas in the female group, L3 showed the strongest negative correlation with age (r=-0.75. In the conclusion, it was found that trabecular bone of L2 showed the most significant correlation to increase in age in males whereas L3 showed the strongest correlation in females. Keywords: Age, Image segmentation, Lumbar, Thai population, Trabecular bone

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