Whether Prophylactic Bilateral Salpingectomy Will Reduce Quality of Life and Ovarian Function?

2017 ◽  
Vol 24 (7) ◽  
pp. S108-S109
Author(s):  
Y. Zheng ◽  
S. Dhakal ◽  
X. Yi
Keyword(s):  
Quality Of Life ◽  
Ovarian Function ◽  
Bilateral Salpingectomy

scholarly journals Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Kyeoung-Hwa Kim ◽  
Eun-Young Kim ◽  
Gi Jin Kim ◽  
Jung-Jae Ko ◽  
Kwang Yul Cha ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Human Placenta ◽  
Ovarian Function ◽  
Therapeutic Potential ◽  
Primordial Follicle ◽  
Serum Levels ◽  
Aged Rats ◽  
Hormone Production ◽  
Smad Signaling

Abstract Background Aging has detrimental effects on the ovary, such as a progressive reduction in fertility and decreased hormone production, that greatly reduce the quality of life of women. Thus, the current study was undertaken to investigate whether human placenta-derived mesenchymal stem cell (hPD-MSC) treatment can restore the decreases in folliculogenesis and ovarian function that occur with aging. Methods Acclimatized 52-week-old female SD rats were randomly divided into four groups: single hPD-MSC (5 × 105) therapy, multiple (three times, 10-day intervals) hPD-MSC therapy, control (PBS), and non-treated groups. hPD-MSC therapy was conducted by tail vein injection into aged rats. The rats were sacrificed 1, 2, 3, and 5 weeks after the last injection. hPD-MSC tracking and follicle numbers were histologically confirmed. The serum levels of sex hormones and circulating miRNAs were detected by ELISA and qRT-PCR, respectively. TGF-β superfamily proteins and SMAD proteins in the ovary were detected by Western blot analysis. Results We observed that multiple transplantations of hPD-MSCs more effectively promoted primordial follicle activation and ovarian hormone (E2 and AMH) production than a single injection. After hPD-MSC therapy, the levels of miR-21-5p, miR-132-3p, and miR-212-3p, miRNAs associated with the ovarian reserve, were increased in the serum. Moreover, miRNAs (miR-16-5p, miR-34a-5p, and miR-191-5p) with known adverse effects on folliculogenesis were markedly suppressed. Importantly, the level of miR-145-5p was reduced after single- or multiple-injection hPD-MSC therapy, and we confirmed that miR-145-5p targets Bmpr2 but not Tgfbr2. Interestingly, downregulation of miR-145-5p led to an increase in BMPR2, and activation of SMAD signaling concurrently increased primordial follicle development and the number of primary and antral follicles. Conclusions Our study verified that multiple intravenous injections of hPD-MSCs led to improved ovarian function via miR-145-5p and BMP-SMAD signaling and proposed the future therapeutic potential of hPD-MSCs to promote ovarian function in women at advanced age to improve their quality of life during climacterium.

scholarly journals Cardiovascular prevention in peri- and postmenopausal women

2011 ◽  
Vol 10 (3) ◽  
pp. 123-130
Author(s):  
N. A. Voychenko ◽  
I. V. Kuznetsova ◽  
V. B. Mychka ◽  
M. Yu. Kirillova ◽  
S. N. Tolstov
Keyword(s):  
Quality Of Life ◽  
Cardiovascular Disease ◽  
Hormone Replacement Therapy ◽  
Postmenopausal Women ◽  
Lower Risk ◽  
Ovarian Function ◽  
Hormone Replacement ◽  
Cardiovascular Prevention ◽  
Cvd Risk

The adverse consequences of estrogen deficiency in postmenopause include cardiovascular disease (CVD), which affects not only women’s quality of life, but also their life expectancy. Before premenopause, women have significantly lower risk of arterial hypertension than men of the same age. However, in people aged over 50, AH is more prevalent among women. Currently, most experts regard hormone replacement therapy (HRT) in peri- and postmenopausal women as pathogenetic, since it facilitates the adaptation of the female organism to the new metabolic state, with reduced ovarian function. Drospirenone, as a part of HRT, reduces CVD risk in postmenopausal women with climacteric disturbances.

scholarly journals Metformin intervention against ovarian toxicity during chemotherapy for early breast cancer: study protocol for a randomized double-blind placebo-controlled trial

2020 ◽  
Author(s):  
Jinjin Zhang ◽  
Xiangyi Ma ◽  
Ya Li ◽  
Ronghua Liu ◽  
Yan Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Ovarian Function ◽  
Objective Response ◽  
Disease Free Survival ◽  
Breast Cancer Patients ◽  
Double Blind

Abstract Background With the significant improvement of the cure rate and survival rate of cancer patients, the survivors need to face quality of life problems, such as significant decline in reproductive system development, ovarian reserves and function, and even fertility loss and early menopause. These problems are often highly associated with chemotherapy-induced ovarian damage in the course of cancer treatment. However, there are no ideal treatment strategies at present. In our attempt to develop reagents and approaches for delaying ovarian aging and protecting chemotherapy-induced ovarian injury, we recently found that metformin may be the most potential drug to protect female malignant tumor patients from chemotherapy-induced ovarian injury. The optional trial is aimed to test whether administration of metformin during chemotherapy could protect normal ovarian function of early breast cancer patients. Methods This study is prospective, randomized, double-blind and placebo-controlled. Female early breast cancer patients (N=314), were randomly assigned to two groups (placebo, metformin 2000 mg). Metformin was administered during and after chemotherapy for patients with stage I-IIIa breast cancer. The primary outcome was the menstruation recovery rate 12 months after chemotherapy, defined as recovery of menstruation twice in a row within 1 year. Patients were followed up for 5 years to observe long-term ovarian function and prognosis of tumor, such as overall survival (OS), objective response rate (ORR), disease-free survival (DFS). Quality of life and safety will also be assessed. Discussion Our research will provide new treatment strategy of fertility protection, and clinical treatment guidance for cancer patients.

Quality of Life Effects of Ovarian Suppression in the Suppression of Ovarian Function Trial

2016 ◽  
Vol 34 (34) ◽  
pp. 4188-4188
Author(s):  
Federica Tomao ◽  
Anselmo Papa ◽  
Silverio Tomao
Keyword(s):  
Quality Of Life ◽  
Ovarian Function ◽  
Ovarian Suppression

Vocal Parameters and Voice-Related Quality of Life in Adult Women With and Without Ovarian Function

2013 ◽  
Vol 27 (3) ◽  
pp. 355-360 ◽  
Author(s):  
Pablo Rodrigo Rocha Ferraz ◽  
Simão Veras Bertoldo ◽  
Luanne Gabrielle Morais Costa ◽  
Emmeliny Cristini Nogueira Serra ◽  
Eduardo Magalhães Silva ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ovarian Function ◽  
Adult Women ◽  
Related Quality

scholarly journals AN APPRAISAL ON PRESERVING POSTMENOPAUSAL QUALITY OF LIFE USING VARIOUS EXERCISES: A PARADIGM SHIFT

2017 ◽  
Vol 6 (1) ◽  
pp. 4-14
Author(s):  
Beenish Zafar ◽  
Nazish Rafique ◽  
Anum Rehan
Keyword(s):  
Quality Of Life ◽  
Ovarian Function ◽  
Balance Training ◽  
Anaerobic Exercise ◽  
Randomized Controlled ◽  
Study Selection ◽  
Increase Risk ◽  
Post Menopausal ◽  
Reduced Mobility

BACKGROUND Menopause is the cessation of ovarian function that mainly leads to osteoporosis. Osteoporosis (OP) initially manifests by presenting pain that leads to reduced mobility and increase risk of stress fracture. OBJECTIVE To compare the effects of widely suggested initial non pharmacological treatment including various exercises on acquiring post menopausal quality of life (QoL). DATA SOURCES The articles were accessed through the Google Scholar, Research gate, PubMed and Science direct that includes Randomized Controlled Trials (RCT). STUDY SELECTION Data included from 2000-2016, females travailed from postmenopausal pains, fractures and limited functioning. RESULTS 20 studies fulfilled the criteria required for this review and hence 1796 participants included, out of them 139 females received anaerobic exercise, 699 received aerobics and balance training while 451 did not perform any exercise. Anaerobic activity delivered extreme value in growing bone density (BMD), muscle bulk over and above lessening the threat of stress fractures, despite a fact that equilibrium exercises enhance kinesis

scholarly journals Managing menopausal symptoms in patients with hormone receptor-positive gynecologic cancers

2020 ◽  
Vol 22 (3) ◽  
pp. 154-159
Author(s):  
O. V. Shabalova ◽  
S. V. Yureneva ◽  
S. V. Khokhlova ◽  
Zh. R. Gardanova ◽  
E. I. Ermakova
Keyword(s):  
Quality Of Life ◽  
Reproductive Tract ◽  
Ovarian Function ◽  
Disease Free Survival ◽  
Climacteric Symptoms ◽  
Effective Treatment Option ◽  
Natural Menopause ◽  
First Line Therapy ◽  
Pharmacological Correction

Young women with reproductive tract neoplasms who receive treatment leading to termination of ovarian function often suffer from menopause symptoms that contribute to dramatic drop in quality of life. Climacteric symptoms in women with iatrogenic menopause are more severe than in case of natural menopause, especially in women with reproductive tract neoplasms. They lead to dramatic drop in quality of life and are one of the main reasons to stop applying endocrine therapy in women with hormone-positive tumors, which leads to decrease in disease free survival and to decline the prognosis. The most effective treatment option for climacteric symptoms of moderate to severe degrees is menopause hormone therapy; however, such therapy is not suitable for patients with estrogen-dependent tumors in past medical history due to the likelihood risk of progression of cancer, as well as the risk of venous thrombosis, the frequency of which in cancer patients increases. Non-hormonal pharmacological and non-pharmacological correction methods are used as first-line therapy for menopause disorders in women with estrogen-dependent tumors of the reproductive system. Among non-hormonal non-pharmacological correction methods actively study such methods as acupuncture, yoga, exercise to control weight, and a diet rich in phytoestrogens. The most effective non-hormonal methods of correcting vasomotor symptoms are serotonin and norepinephrine reuptake inhibitors. However, currently in Russia these drugs can be prescribed only by a psychiatrist. The finding of effective and safe non-hormonal methods to correct menopause symptoms in women with hormone-positive reproductive tract tumors is the important task in practice among doctors in different specialties.

scholarly journals Treatment Efficacy, Adherence, and Quality of Life Among Women Younger Than 35 Years in the International Breast Cancer Study Group TEXT and SOFT Adjuvant Endocrine Therapy Trials

2017 ◽  
Vol 35 (27) ◽  
pp. 3113-3122 ◽  
Author(s):  
Poornima Saha ◽  
Meredith M. Regan ◽  
Olivia Pagani ◽  
Prudence A. Francis ◽  
Barbara A. Walley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Treatment Efficacy ◽  
Ovarian Function ◽  
Growth Factor Receptor ◽  
Premenopausal Women ◽  
Epidermal Growth

Purpose To describe benefits and toxicities of adjuvant endocrine therapies in women younger than 35 years with breast cancer (n = 582) enrolled in the Suppression of Ovarian Function Trial (SOFT) and Tamoxifen and Exemestane Trial (TEXT). Methods In SOFT, women still premenopausal after surgery with or without chemotherapy were randomly assigned to tamoxifen alone, tamoxifen plus ovarian function suppression (OFS), or exemestane plus OFS. In TEXT, all received OFS with or without concomitant chemotherapy and were randomly assigned to exemestane plus OFS or tamoxifen plus OFS. We summarize treatment efficacy, quality of life, and adherence of the cohort of women younger than 35 years in SOFT and TEXT, alongside data from the cohort of older premenopausal women. Results For 240 human epidermal growth factor receptor 2–negative patients younger than 35 years enrolled in SOFT after receiving chemotherapy, the 5-year breast cancer–free interval (BCFI) was 67.1% (95% CI, 54.6% to 76.9%) with tamoxifen alone, 75.9% with tamoxifen plus OFS (95% CI, 64.0% to 84.4%), and 83.2% with exemestane plus OFS (95% CI, 72.7% to 90.0%). For 145 human epidermal growth factor receptor 2–negative patients younger than 35 years in TEXT, 5-year BCFI was 79.2% (95% CI, 66.2% to 87.7%) with tamoxifen plus OFS and 81.6% (95% CI, 69.8% to 89.2%) with exemestane plus OFS. The most prominent quality of life symptom for patients younger than 35 years receiving OFS was vasomotor symptoms, with the greatest worsening from baseline at 6 months (on the order of 30 to 40 points), but loss of sexual interest and difficulties in becoming aroused were also clinically meaningful (≥ 8-point change). The level of symptom burden was similar in older premenopausal women. A total of 19.8% of women younger than 35 years stopped all protocol-assigned endocrine therapy early. Conclusion In women younger than 35 years with hormone receptor–positive breast cancer, adjuvant OFS combined with tamoxifen or exemestane produces large improvements in BCFI compared with tamoxifen alone. Menopausal symptoms are significant but are not worse than those seen in older premenopausal women.

scholarly journals Impact of 6 Weeks Pilates Training on Menopause Specific Symptoms and Quality of Life in Menopausal Women: A Case Report

2021 ◽  
pp. 83-89
Author(s):  
Anjali Bais ◽  
Simran A. Mishra ◽  
Palak P. Darda ◽  
Pratik Phansopkar
Keyword(s):  
Quality Of Life ◽  
Muscle Strength ◽  
Ovarian Function ◽  
Negative Impact ◽  
Treatment Protocol ◽  
Core Stability ◽  
Main Concern ◽  
Common Symptom ◽  
Lower Back

Introduction: The concept of menopause is a complete cessation of ovarian function. Most common symptom of menopause include muscle and joint ache, poor memory, lower back pain and trouble sleeping. The vasomotor and emotional domains reported less often compared with the physical and psychological domains. Such adverse changes in physical and mental health may have a negative impact on Quality of Life (QOL). Pilates is a mind body exercise focusing on muscle strength, core stability, endurance, muscle control, posture, and respiration which seems to improve both the physical and psychological components in women during menopause. The given study helps to provide the effect of 6 weeks Pilates training protocol on menopausal women’s presenting complaints as well as on her QOL. Complaints and clinical finding: Patient’s main concern were low back ache without any cause night sweats, fatigue, disturbed sleep wake cycle which lead to difficulties in performing activities of daily living which hampered the QOL of the patient. Physical findings revealed decrement in lower back and lower limb muscle strength along with some tightness. Scales helped to reveal that patient is having fatigue and tiredness and mat-exercise treatment protocol were formed. Therapeutic Intervention: 6 weeks Pilates training. Conclusion: As there are minimal to no evidence present in reference to this study, it helps us to provide new and proper treatment protocol and it is helpful to know the effect of the same. It showed significant improvement in the muscular strength as well as reduction in stress level and helped in enhancing the QOL of the patient.

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