Interrogating autonomic peripheral nervous system neurons with viruses – A literature review

2020 ◽  
Vol 346 ◽  
pp. 108958
Author(s):  
Maohui Feng ◽  
Boqi Xiang ◽  
Li Fan ◽  
Qian Wang ◽  
Weiguo Xu ◽  
...  
Keyword(s):  
Nervous System ◽  
Literature Review ◽  
Peripheral Nervous System

scholarly journals Neurological manifestations and pathophysiological mechanisms of Covid-19

2021 ◽  
Vol 10 (7) ◽  
pp. 1040-1047
Author(s):  
Cristiano Gaujac ◽  
Regiane Cristina Amaral
Keyword(s):  
Nervous System ◽  
Severe Acute Respiratory Syndrome ◽  
Literature Review ◽  
Peripheral Nervous System ◽  
Etiologic Agent ◽  
Neurological Involvement ◽  
Neurological Manifestations ◽  
Pathophysiological Mechanisms ◽  
Life Threatening ◽  
The Relationship

Background - Severe acute respiratory syndrome coronavirus-2 is a novel, highly infectious coronavirus and the etiologic agent of Covid-19. The course of Covid-19 can range from mild flu-like symptoms to severe, life-threatening symptoms, especially when comorbidities are present. Increasing studies have reinforced the association between SARS-CoV-2 and various neurological manifestations, although the pathophysiological mechanisms remain uncertain. Objective - The aim of this paper was to briefly describe current findings on the relationship between SARS-CoV-2 pathophysiology and major CNS and Peripheral Nervous System (PNS) manifestations. Methods and Material - This work consists of a literature review based on the study of academic papers. To this end, the Pubmed platform was used to search for scientific articles, using the keywords: covid-19, coronavirus, physiopathology, neuronal symptoms. Results - out of 114,660 articles found, 94 were selected for this review. Conclusions - Periodic reviews collaborate in the constant updating and summarization of findings. Understanding the pathophysiology of SARS-CoV-2 on the SN and the link between the systems may lead to earlier and earlier diagnoses of neurological involvement, guide therapeutic management, prevent sequelae, and preserve lives.

scholarly journals Atypical presentation of Lyme neuroborreliosis related meningitis and radiculitis

2019 ◽  
Vol 11 (4) ◽  
Author(s):  
Iman Dabiri ◽  
Nicholas Calvo ◽  
Feryal Nauman ◽  
Mahsa Pahlavanzadeh ◽  
Ahmet Z. Burakgazi
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Literature Review ◽  
Peripheral Nervous System ◽  
Nerve Root ◽  
Clinical Presentation ◽  
Lyme Neuroborreliosis ◽  
Atypical Presentation ◽  
Neurologic Manifestations ◽  
Unique Case

Lyme disease related central and peripheral nervous system manifestations can occur in isolation or together. Radiculitis or inflammation of the nerve root can be seen 3-5% of the time in acute neuroborreliosis affecting the PNS with a typical presentation and meningitis affecting the CNS is usually seen 1% of the time. The appropriate diagnosis and management of neuroborelliosis can be challenging and require meticulous medical approaches. Herein we present a unique case of Lyme disease with neurologic manifestations including both radiculitis and meningitis due to its atypical and challenging clinical presentation and management with updated literature review.

scholarly journals Acute and chronic dysimmune polyneuropathies in the context of the COVID-19 pandemic: pathogenesis, features of the clinical picture, diagnosis and therapy (literature review)

2021 ◽  
Vol 11 (2) ◽  
pp. 17-27
Author(s):  
A. E. Khrulev ◽  
N. A. Shiyanova ◽  
S. N. Sorokoumova ◽  
D. S. Kasatkin ◽  
V.  N. Grigoryeva ◽  
...  
Keyword(s):  
Nervous System ◽  
Differential Diagnosis ◽  
Literature Review ◽  
Peripheral Nervous System ◽  
Clinical Features ◽  
Clinical Picture ◽  
Specific Therapy ◽  
Diagnosis And Management ◽  
Current Information ◽  
Mechanisms Of Development

Dysimmune polyneuropathies are the etiologically heterogeneous group of diseases with autoimmune damage to the peripheral nervous system. The rarity of these diseases doesn’t exclude the possibility of their development or exacerbation in patients infected with SARS‑CoV‑2, which will require timely differential diagnosis and urgent specific therapy. The article summarizes current information on the mechanisms of development, clinical features, diagnosis and management of acute and chronic dysimmune polyneuropathies in the context of the COVID‑19 pandemic.

scholarly journals Peripheral nervous system damage in hypothyroidism: current view on the problem (literature review)

2017 ◽  
Vol 13 (4) ◽  
pp. 257-261
Author(s):  
О.А. Olenovych ◽  
N.V. Pashkovska ◽  
V.M. Pashkovskyy ◽  
I.V. Boyko
Keyword(s):  
Nervous System ◽  
Literature Review ◽  
Peripheral Nervous System ◽  
Current View

Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

1995 ◽  
Vol 53 ◽  
pp. 958-959
Author(s):  
S.S. Spicer ◽  
B.A. Schulte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Sensory Nerves ◽  
Tissue Antigens ◽  
The Central Nervous System ◽  
The Brain ◽  
Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

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