scholarly journals Atypical presentation of Lyme neuroborreliosis related meningitis and radiculitis

2019 ◽  
Vol 11 (4) ◽  
Author(s):  
Iman Dabiri ◽  
Nicholas Calvo ◽  
Feryal Nauman ◽  
Mahsa Pahlavanzadeh ◽  
Ahmet Z. Burakgazi
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Literature Review ◽  
Peripheral Nervous System ◽  
Nerve Root ◽  
Clinical Presentation ◽  
Lyme Neuroborreliosis ◽  
Atypical Presentation ◽  
Neurologic Manifestations ◽  
Unique Case

Lyme disease related central and peripheral nervous system manifestations can occur in isolation or together. Radiculitis or inflammation of the nerve root can be seen 3-5% of the time in acute neuroborreliosis affecting the PNS with a typical presentation and meningitis affecting the CNS is usually seen 1% of the time. The appropriate diagnosis and management of neuroborelliosis can be challenging and require meticulous medical approaches. Herein we present a unique case of Lyme disease with neurologic manifestations including both radiculitis and meningitis due to its atypical and challenging clinical presentation and management with updated literature review.

scholarly journals Neuroborreliosis – clinical presentation – Current state of knowledge

2019 ◽  
pp. 321-328 ◽  
Author(s):  
Katarzyna Krawczuk ◽  
Piotr Czupryna ◽  
Sławomir Pancewicz ◽  
Elżbieta Ołdak ◽  
Monika Król ◽  
...  
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Peripheral Nervous System ◽  
Clinical Presentation ◽  
Clinical Symptoms ◽  
Clinical Course ◽  
Tick Bites ◽  
Current State ◽  
Adults And Children

Neuroborreliosis is one of the manifestations of Lyme disease involving central and peripheral nervous system. It is caused by infection with Borrelia burgdorferi spirochete which is transmitted by tick bites. Neuroborreliosis can affect both adults and children. The clinical course in children is often different than in adults. The article discusses the most common clinical symptoms, complications, diagnostics and treatment of neuroborreliosis in children.

scholarly journals Unusual Presentation of Unilateral Isolated Probable Lyme Optic Neuritis

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Ahmet Z. Burakgazi ◽  
Carl S. Henderson
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Differential Diagnosis ◽  
Lyme Disease ◽  
Literature Review ◽  
Optic Neuritis ◽  
Central Nervous System Involvement ◽  
Detailed Examination ◽  
Ocular Manifestation ◽  
Unique Case

Optic neuritis (ON) is one of the most common manifestations of central nervous system involvement caused by various etiologies. Lyme ON is an exceedingly rare ocular manifestation of Lyme disease (LD) and only a few cases have been published in the literature. Lyme ON is very rare but should be included in the differential diagnosis in unexplained cases, particularly in Lyme endemic areas. Careful and detailed examination and investigation are warranted to make the diagnosis. We report this case to increase awareness of clinicians to include Lyme disease in differential diagnosis of ON for unexplained cases of ON. Herein we present a unique case with a unilateral ON caused by LD along with pre- and posttreatment findings and literature review.

Cerebrospinal Fluid Cytology of Lyme Neuroborreliosis: A Report of 3 Cases with Literature Review

2015 ◽  
Vol 59 (4) ◽  
pp. 339-344 ◽  
Author(s):  
Juan Xing ◽  
Lisa Radkay ◽  
Sara E. Monaco ◽  
Christine G. Roth ◽  
Liron Pantanowitz
Keyword(s):  
Central Nervous System ◽  
Flow Cytometry ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Lyme Disease ◽  
B Cell ◽  
Plasma Cells ◽  
Lyme Neuroborreliosis ◽  
Chain Analysis ◽  
The Central Nervous System

Lyme disease can affect the central nervous system causing a B-cell-predominant lymphocytic pleocytosis. Since most reactions to infection in the cerebrospinal fluid (CSF) are typically T-cell predominant, a B-cell-predominant lymphocytosis raises concern for lymphoma. We present 3 Lyme neuroborreliosis cases in order to illustrate the challenging cytomorphological and immunophenotypic features of their CSF specimens. Three male patients who presented with central nervous system manifestations were diagnosed with Lyme disease. The clinical presentation, laboratory tests, CSF cytological examination and flow-cytometric studies were described for each case. CSF cytology showed lymphocytic pleocytosis with increased plasmacytoid cells and/or plasma cells. Flow cytometry showed the presence of polytypic B lymphocytes with evidence of plasmacytic differentiation in 2 cases. In all cases, Lyme disease was confirmed by the Lyme screening test and Western blotting. In such cases of Lyme neuroborreliosis, flow cytometry of CSF samples employing plasmacytic markers and cytoplasmic light-chain analysis is diagnostically helpful to exclude lymphoma.

scholarly journals Solitary neurofibroma of maxilla: a rare clinical entity

2020 ◽  
Vol 13 (2) ◽  
pp. e232925
Author(s):  
Meetkamal Grewal ◽  
Nitin Saini ◽  
Swati Gautam ◽  
Preeti Garg
Keyword(s):  
Nervous System ◽  
Soft Tissue ◽  
Head And Neck ◽  
Peripheral Nervous System ◽  
Male Patient ◽  
Neck Region ◽  
Rare Clinical Entity ◽  
Unique Case ◽  
Head And Neck Region ◽  
Solitary Neurofibroma

Neurofibroma (NF) is a benign tumour of the peripheral nervous system which is rare in head and neck region. Head and neck NF are mostly located in the soft tissue and rarely seen intraosseously. These may present either as solitary lesions or as part of the generalised syndrome of neurofibromatosis or von Recklinghausen's disease of the skin. The intraosseous ones are most commonly seen as solitary lesions, rather than part of neurofibromatosis. The following report describes a unique case of a solitary neurofibroma of the maxilla without generalised syndrome of neurofibromatosis in a male patient.

Interrogating autonomic peripheral nervous system neurons with viruses – A literature review

2020 ◽  
Vol 346 ◽  
pp. 108958
Author(s):  
Maohui Feng ◽  
Boqi Xiang ◽  
Li Fan ◽  
Qian Wang ◽  
Weiguo Xu ◽  
...  
Keyword(s):  
Nervous System ◽  
Literature Review ◽  
Peripheral Nervous System

scholarly journals Pathogenesis of Lyme Neuroborreliosis in the Rhesus Monkey: The Early Disseminated and Chronic Phases of Disease in the Peripheral Nervous System

1998 ◽  
Vol 178 (3) ◽  
pp. 722-732 ◽  
Author(s):  
E. Donald Roberts ◽  
Rudolf P. Bohm, Jr. ◽  
Robert C. Lowrie, Jr. ◽  
Gail Habicht ◽  
Laura Katona ◽  
...  
Keyword(s):  
Nervous System ◽  
Rhesus Monkey ◽  
Peripheral Nervous System ◽  
Lyme Neuroborreliosis

scholarly journals Predicting the risk of neurological complications in the erythemal form of ixodes Lyme disease

2016 ◽  
Vol 21 (6) ◽  
pp. 341-346
Author(s):  
D. Yu Moshkova ◽  
Marina G. Avdeeva
Keyword(s):  
Nervous System ◽  
Lyme Disease ◽  
Peripheral Nervous System ◽  
Lyme Borreliosis ◽  
Inflammatory Cytokine ◽  
Neurological Complications ◽  
Average Level ◽  
Pathogenetic Therapy ◽  
Chronic Course

The aim. The prediction of risk degrees of neurological complications in adult patients with erythemal form of borreliosis for the timely appointment of causal and pathogenetic therapy. Materials and methods. We observed 46 patients hospitalized in infectious hospital in Krasnodar in 2013-2014, with a diagnosis of Ixodes tick-borne Lyme disease, erythemal form, acute course was observed in 41 (89.1%) person, subacute - in 2 (4.4%), chronic - 3 (6.5%). In the course of the disease there was studied the level of pro-inflammatory cytokine IFN-y. Results. The average age of patients was 41.1 ± 1.83 years, among them women (63%) dominated. In 31% of patients there were observed symptoms of the damage of the nervous system. From the first week of the disease there was noted a significant increase in the level of IFN-y, which persisted both in the subacute and chronic course of the disease. The average level of IFN-y in patients with signs of the damage of the central and peripheral nervous system accounted for 64.8±14.19 pg/ml being ignificantly higher (P 20.0 pg/ml symptoms of the damage of the nervous system were recorded in 50% of cases. The degrees of neurological complications risk in patients with tick-borne Lyme disease are determined: the IFN-y level of 20.0-34.99 pg/ml predicted the risk of 1 degree (12.5%), level of 35,0-79,99 pg/ml - the risk of 2 degree (45%), the level higher than 80.0pg/ml - the risk of 3 degree (100%). Conclusion. The use of the determination of the IFN-y level can increase the accuracy and provide the timeliness of diagnosis of neurological complications in Lyme borreliosis cases, that is important for the prognosis and treatment of the disease.

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