Serum neurofilament light is a sensitive biomarker that reflects grey matter volume in Japanese patients with multiple sclerosis

2021 ◽  
pp. 117528
Author(s):  
Juichi Fujimori ◽  
Ichiro Nakashima
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Japanese Patients ◽  
Grey Matter Volume ◽  
Neurofilament Light ◽  
Matter Volume

Whole brain and grey matter volume of Japanese patients with multiple sclerosis

2017 ◽  
Vol 306 ◽  
pp. 68-75 ◽  
Author(s):  
Tetsuya Akaishi ◽  
Ichiro Nakashima ◽  
Shunji Mugikura ◽  
Masashi Aoki ◽  
Kazuo Fujihara
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Japanese Patients ◽  
Grey Matter Volume ◽  
Whole Brain ◽  
Matter Volume

Cerebrospinal fluid neurofilament light levels mark grey matter volume in clinically isolated syndrome suggestive of multiple sclerosis

2017 ◽  
Vol 24 (8) ◽  
pp. 1039-1045 ◽  
Author(s):  
Carla Tortorella ◽  
Vita Direnzo ◽  
Maddalena Ruggieri ◽  
Stefano Zoccolella ◽  
Mariangela Mastrapasqua ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
White Matter ◽  
Grey Matter ◽  
Brain Volume ◽  
Clinically Isolated Syndrome ◽  
Grey Matter Volume ◽  
Neurofilament Light ◽  
Brain Volumes ◽  
Matter Volume

Background: Brain atrophy is a known marker of irreversible tissue damage in multiple sclerosis (MS). Cerebrospinal fluid (CSF) osteopontin (OPN) and neurofilament light chain (NF-L) have been proposed as candidate surrogate markers of inflammatory and neurodegenerative processes in MS. Objective: To evaluate the relationship between CSF NF-L and OPN levels and brain grey and white matter volumes in patients with clinically isolated syndrome (CIS) suggestive of MS. Methods: A total of 41 CIS patients and 30 neurological controls (NCs) were included. CSF NF-L and OPN were measured by commercial ELISA. Measures of brain volume (normalized brain volume (NBV), normalized grey matter volume (NGV), peripheral grey matter volume (PGV), normalized white matter volume (WMV), and ventricular volume) were obtained by SIENAX. Corpus callosum index (CCI) was calculated. Brain volumes were categorized into ‘high’ and ‘low’ according to the median value. Results: CSF NF-L and OPN levels were higher in CIS patients in comparison with NCs. CIS patients with ‘low’ TGV, PGV, and TBV showed higher CSF NF-L levels than CIS patients with ‘high’ brain volumes. TGV and PGV correlated inversely with NF-L levels, whereas CCI was inversely related to OPN levels. CSF NF-L was the only independent predictor of TGV and PGV. Conclusion: CSF NF-L tracks mainly grey matter damage in patients with CIS suggestive of MS.

scholarly journals Usefulness of two-dimensional measurements for the evaluation of brain volume and disability in multiple sclerosis

2022 ◽  
Vol 8 (1) ◽  
pp. 205521732110707
Author(s):  
Satori Ajitomi ◽  
Juichi Fujimori ◽  
Ichiro Nakashima
Keyword(s):  
Multiple Sclerosis ◽  
Processing Speed ◽  
Lateral Ventricle ◽  
Grey Matter ◽  
Brain Volume ◽  
Grey Matter Volume ◽  
Two Dimensional ◽  
Whole Brain ◽  
Brain Volumes ◽  
Matter Volume

Background Two-dimensional (2D) measures have been proposed as potential proxies for whole-brain volume in multiple sclerosis (MS). Objective To verify whether 2D measurements by routine MRI are useful in predicting brain volume or disability in MS. Methods In this cross-sectional analysis, eighty-five consecutive Japanese MS patients—relapsing-remitting MS (81%) and progressive MS (19%)—underwent 1.5 Tesla T1-weighted 3D MRI examinations to measure whole-brain and grey matter volume. 2D measurements, namely, third ventricle width, lateral ventricle width (LVW), brain width, bicaudate ratio, and corpus callosum index (CCI), were obtained from each scan. Correlations between 2D measurements and 3D measurements, the Expanded Disability Status Scale (EDSS), or processing speed were analysed. Results The third and lateral ventricle widths were well-correlated with the whole-brain volume ( p < 0.0001), grey matter volume ( p < 0.0001), and EDSS scores ( p = 0.0001, p = .0004, respectively).The least squares regression model revealed that 78% of the variation in whole-brain volume could be explained using five explanatory variables, namely, LVW, CCI, age, sex, and disease duration. By contrast, the partial correlation coefficient excluding the effect of age showed that the CCI was significantly correlated with the EDSS and processing speed ( p < 0.0001). Conclusion Ventricle width correlated well with brain volumes, while the CCI correlated well with age-independent (i.e. disease-induced) disability.

Genes associated with grey matter volume reduction in multiple sclerosis

2021 ◽  
Author(s):  
Jie Sun ◽  
Yingying Xie ◽  
Qiuhui Wang ◽  
Junlin Shen ◽  
Wen Qin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Volume Reduction ◽  
Grey Matter Volume ◽  
Matter Volume

scholarly journals Determinants of Disability in Multiple Sclerosis: An Immunological and MRI Study

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Paola Tortorella ◽  
Maria Marcella Laganà ◽  
Marina Saresella ◽  
Eleonora Tavazzi ◽  
Maria Giulia Preti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Mononuclear Cells ◽  
Diffusion Tensor ◽  
Brain Mri ◽  
Motor Impairment ◽  
Grey Matter Volume ◽  
Peripheral Blood Mononuclear ◽  
Matter Volume

Multiple sclerosis (MS) is characterized by a wide interpatient clinical variability and available biomarkers of disease severity still have suboptimal reliability. We aimed to assess immunological and MRI-derived measures of brain tissue damage in patients with different motor impairment degrees, forin vivoinvestigating the pathogenesis of MS-related disability. Twenty-two benign (B), 26 secondary progressive (SP), and 11 early, nondisabled relapsing-remitting (RR) MS patients and 37 healthy controls (HC) underwent conventional and diffusion tensor brain MRI and, as regards MS patients, immunophenotypic and functional analysis of stimulated peripheral blood mononuclear cells (PBMC). Corticospinal tract (CST) fractional anisotropy and grey matter volume were lower and CST diffusivity was higher in SPMS compared to RRMS and BMS patients. CD14+IL6+ and CD4+IL25+ cell percentages were higher in BMS than in SPMS patients. A multivariable model having EDSS as the dependent variable retained the following independent predictors: grey matter volume, CD14+IL6+ and CD4+IL25+ cell percentages. In patients without motor impairment after long-lasting MS, the grey matter and CST damage degree seem to remain as low as in the earlier disease stages and an immunological pattern suggestive of balanced pro- and anti-inflammatory activity is observed. MRI-derived and immunological measures might be used as complementary biomarkers of MS severity.

scholarly journals Comparison of cognitive and brain grey matter volume profiles between multiple sclerosis and neuromyelitis optica spectrum disorder

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0184012 ◽  
Author(s):  
Hiroki Masuda ◽  
Shigeki Hirano ◽  
Nobuyoshi Takahashi ◽  
Etsuko Hatsugano ◽  
Akiyuki Uzawa ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neuromyelitis Optica ◽  
Grey Matter ◽  
Spectrum Disorder ◽  
Grey Matter Volume ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Matter Volume

Two-year study of cervical cord volume and myelin water in primary progressive multiple sclerosis

2010 ◽  
Vol 16 (6) ◽  
pp. 670-677 ◽  
Author(s):  
C. Laule ◽  
IM Vavasour ◽  
Y. Zhao ◽  
AL Traboulsee ◽  
J. Oger ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Glatiramer Acetate ◽  
Grey Matter ◽  
Interquartile Range ◽  
Cervical Cord ◽  
Controlled Clinical Trial ◽  
Grey Matter Volume ◽  
Primary Progressive Multiple Sclerosis ◽  
Primary Progressive ◽  
Matter Volume

Background: Spinal cord involvement in multiple sclerosis (MS) is common and an important element in disability. Previous studies demonstrated smaller cervical cord area at the C2 level in MS compared to controls, and a decrease in cord area over 12 months, most marked in primary progressive MS (PPMS). A subset of subjects participating in a multicentre, double-blind, placebo-controlled clinical trial evaluating the efficacy of glatiramer acetate in PPMS (PROMiSe trial) were followed for 2 years. Methods: 24 PPMS subjects, randomized to placebo ( n = 9) and glatiramer acetate ( n = 15), and 24 matched controls were studied. Cervical cord volume (CCV) at C2—3 was determined using a 3D inversion recovery (IR)-prepared spoiled-gradient echo sequence. Myelin water fraction (MWF) at C2—3 was obtained using a 32-echo IR-prepared relaxation sequence. Scans were repeated at baseline, years 1 and 2. Results: Baseline CCV was significantly smaller for PPMS than controls [median (interquartile range) 951 (829—1043) vs. 1072 (1040—1129) mm3, p = 0.0004] and MWF trended to be lower in PPMS cord [median (interquartile range) 0.225 (0.187—0.267) vs. 0.253 (0.235—0.266), p = 0.12]. Baseline CCV correlated with baseline Expanded Disability Status Scale, disease duration, brain white and grey matter volume. In PPMS, CCV was significantly decreased at year 1 (—0.83%, p = 0.04) and year 2 (—1.65%, p = 0.02). Baseline MWF correlated with baseline CCV and brain white and grey matter volume. MWF was significantly decreased from baseline for PPMS at year 2 (—10.5%, p = 0.01). Treatment effect was not detected on change in CCV nor MWF. Conclusions: Metrics at the level of the cord, including volume and MWF at C2—3, were lower in PPMS than controls and changed over 2 years only in PPMS.

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