Low concentrations of bilirubin protect from dopaminergic neuron loss in an ex vivo model of Parkinson's disease

2021 ◽  
Vol 429 ◽  
pp. 119566
Author(s):  
Sri Jayanti ◽  
Rita Moretti ◽  
Claudio Tiribelli ◽  
Silvia Gazzin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopaminergic Neuron ◽  
Ex Vivo ◽  
Ex Vivo Model ◽  
Neuron Loss ◽  
Low Concentrations ◽  
Dopaminergic Neuron Loss

scholarly journals Microbiome changes: an indicator of Parkinson’s disease?

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Caroline Haikal ◽  
Qian-Qian Chen ◽  
Jia-Yi Li
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gut Microbiome ◽  
Dopaminergic Neuron ◽  
Alpha Synuclein ◽  
Neuron Loss ◽  
The Future ◽  
Dopaminergic Neuron Loss

AbstractParkinson’s disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research.

scholarly journals Functional Rescue of Dopaminergic Neuron Loss in Parkinson's Disease Mice After Transplantation of Hematopoietic Stem and Progenitor Cells

EBioMedicine ◽  
2016 ◽  
Vol 8 ◽  
pp. 83-95 ◽  
Author(s):  
Wassim Altarche-Xifro ◽  
Umberto di Vicino ◽  
Maria Isabel Muñoz-Martin ◽  
Analía Bortolozzi ◽  
Jordi Bové ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Progenitor Cells ◽  
Dopaminergic Neuron ◽  
Hematopoietic Stem ◽  
Neuron Loss ◽  
Stem And Progenitor Cells ◽  
Dopaminergic Neuron Loss

scholarly journals Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson’s Disease

Cell Reports ◽  
2017 ◽  
Vol 18 (5) ◽  
pp. 1132-1143 ◽  
Author(s):  
Li Song ◽  
Yijing He ◽  
Jiayao Ou ◽  
Yongbo Zhao ◽  
Ruoyu Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopaminergic Neuron ◽  
Neuron Loss ◽  
Drosophila Model ◽  
Locomotor Deficits ◽  
Dopaminergic Neuron Loss

scholarly journals Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

2003 ◽  
Vol 100 (23) ◽  
pp. 13650-13655 ◽  
Author(s):  
P. D. Smith ◽  
S. J. Crocker ◽  
V. Jackson-Lewis ◽  
K. L. Jordan-Sciutto ◽  
S. Hayley ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Dopaminergic Neuron ◽  
Cyclin Dependent Kinase ◽  
Neuron Loss ◽  
Dopaminergic Neuron Loss ◽  
Cyclin Dependent Kinase 5
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