scholarly journals Single or combined cadmium and aluminum intoxication of mice liver and kidney with possible effect of zinc

2016 ◽  
Vol 77 ◽  
pp. 91-101 ◽  
Author(s):  
Ahmed S. Ibraheem ◽  
Amin A. Seleem ◽  
Mohamed F. El-Sayed ◽  
Basma H. Hamad
Keyword(s):  
Liver And Kidney ◽  
Mice Liver ◽  
Aluminum Intoxication

scholarly journals Chrysin protects mice liver and kidney from methandienone-induced oxi-dative ‎stress, inflammation a multi-biomarker approach

2019 ◽  
Vol 10 (2) ◽  
pp. 1081-1088
Author(s):  
Marwah Y. Falih ◽  
Abbas A. Mohammed ◽  
Ghassan M. Sulaiman
Keyword(s):  
Combined Treatment ◽  
Serum Levels ◽  
Hepatic Function ◽  
Oxidation Activity ◽  
Biochemical Effects ◽  
Liver And Kidney ◽  
Anti Oxidant ◽  
Mice Liver ◽  
Kidney Functions ◽  
Renal Function Tests

Methandienone is a medication that has wide uses by competitors and young people in ‎gyms ‎for fitness. Chrysin (CR) is a characteristic natural flavonoid that has to incorporate ‎being a ‎cancer prevention agent, anti-inflammatory and anti-oxidant agent. Mus Musculus ‎mice ‎were therefore used in the current work to test the effects of methandienone on ‎vital ‎physiological functions as expressed by the liver, renal function tests and oxidation ‎activity. ‎The reverse effects of chrysin were also tested for the treatment of methandienone in ‎order ‎to determine the possibility of lowering levels of side effects. The results showed ‎clear ‎changes in biochemical effects on liver and kidney functions as a result of treatment ‎with ‎methandienone were also evident; The treated mice showed a significant elevation in ‎the ‎concentrations of serum levels of the hepatic function enzymes (ALP, AST, ALT) ‎and ‎kidney functions parameters (urea and creatinine).‎‏ ‏Combined treatment of mice ‎with ‎‎(methandienone + 25 mg/kg chrysin) caused a significant reduction in urea level ‎and ‎activities of ALP, ALT and AST (p<0.05) as compared to treatment with ‎methandienone ‎alone. Treatment with (methandienone + 50 mg/kg chrysin) also resulted in ‎a significant ‎decrease in the renal level and ALP and AST activities as compared to methandienone- ‎treated ‎mice. The present study concludes that methandienone causes damages to the liver ‎and the ‎kidney, as indicated by elevated levels of their functional enzymes. This effect ‎indicates ‎it increases oxidative stress in these organs, possibly due to elevated production of ‎free ‎radicals.

scholarly journals The Effect of Papaya (Carica papaya L.) Leaf Extract to the Number of Trypanosoma evansi Steel in Liver and Kidney of Mice (Mus musculus L. 1758)

2017 ◽  
Vol 3 (4) ◽  
pp. 275
Author(s):  
Yudi Yahya ◽  
Anni Nurliani ◽  
Heri Budi Santoso
Keyword(s):  
Carica Papaya ◽  
Degenerative Change ◽  
Ethanolic Extract ◽  
Trypanosoma Evansi ◽  
Cellular Infiltration ◽  
Vacuolar Degeneration ◽  
Cytological Smear ◽  
Liver And Kidney ◽  
Mice Liver ◽  
Kidney Liver

<p class="Els-Abstract-text">The purpose of this study proved the activity of the ethanolic extract of papaya leaf as anti-trypanosomiasis agent, determined the dose of extract which having an effect in inhibiting growth of <em>T. evansi</em>, and evaluated the histopathology of liver and kidney infected by <em>T</em><em>rypanosoma evansi</em> Steel. Male Balb-c mice were infected by 3 × 10<sup>7</sup> <em>T. evansi</em> isolates. The native method was used to determine the level of parasitemia.The preparation was made using cytological smear method and paraffin method. The results showed that ethanolic extract of papaya leaf decreased the number of <em>T. evansi</em>. Ethanolic extract of papaya leaf at a dose of 300 mg · kg<sup>–</sup><sup>1</sup> BW is the most influential dose to reduce the number of <em>T. evansi</em> in liver and kidney of mice. Liver reveals degenerative change varying such as congestion, lipid degeneration, vacuolar degeneration, necrosis, and cellular infiltration. Kidney reveals tubular degeneration, necrosis, cellular infiltration, and glomerulonephritis.</p><p class="Els-Abstract-text"> </p><p><strong>Keywords:</strong> <em>Carica papaya</em> L.; kidney; liver; mice; <em>Trypanosoma evansi</em> Steel</p>

scholarly journals Suppressive effect of goat bile in Plasmodium berghei ANKA infection in mice

2021 ◽  
pp. 2016-2022
Author(s):  
Heny Arwati ◽  
Ramadhani R. Bahalwan ◽  
Windya T. Hapsari ◽  
Kartika A. Wardhani ◽  
Kholida N. Aini ◽  
...  
Keyword(s):  
Plasmodium Berghei ◽  
Plasma Levels ◽  
Suppressive Effect ◽  
Positive Control ◽  
Toxicity Tests ◽  
Plasmodium Berghei Anka ◽  
Group 4 ◽  
Liver And Kidney ◽  
Healthy Control ◽  
Mice Liver

Background and Aim: Some individuals in Indonesia consume intact goat gallbladder to prevent and treat malaria. The acute and subacute toxicity tests of goat bile (GB) have shown mild diarrhea in mice. Therefore, this study aimed to evaluate the suppressive effect of GB on parasitemia, splenomegaly, hepatomegaly, and blood biochemistry to assess liver and kidney function in BALB/c mice infected with Plasmodium berghei ANKA. Materials and Methods: Fifty healthy mice were infected with P. berghei ANKA and divided into five groups. Mice in three groups were administered 0.5 mL of 25%, 50%, or 100% of GB by gavage. Animals in Group 4 were administered 187.2 mg/kg BW of dihydroartemisinin-piperaquine phosphate as a positive control (POS Group). Mice in fifth group were administered sterile water as negative (NEG) controls. Further, 30 uninfected mice were divided into groups 6-8 and administered GB as were mice in the first three groups. Group 9 included 10 uninfected and untreated animals as healthy controls. Treatments were administered in a 4-day suppressive test followed by daily observation of Giemsa-stained blood smears. On day 7, mice were sacrificed to measure the length and weight of spleens and livers, plasma levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine. Results: GB suppressed parasitemia but did not affect the size and weight of spleens or livers or plasma levels of AST and ALT compared to uninfected GB-treated and healthy control animals. Conversely, plasma levels of BUN and creatinine were suppressed and remained in the normal range in all groups of mice. Conclusion: GB suppresses parasitemia with no significant impact on hepatic enzymes in GB-treated infected mice. Liver dysfunction in GB-treated infected mice was due to P. berghei rather than GB treatment.

Tartrazine induced oxidative damage in mice liver and kidney

2018 ◽  
Vol 7 (6) ◽  
pp. 271-278
Author(s):  
Latifa Alioui ◽  
Nabila Mehedi ◽  
Bouhada Youcef ◽  
Omar Kheroua ◽  
Djamel Saidi
Keyword(s):  
Oxidative Stress ◽  
Body Weight Gain ◽  
The Body ◽  
Protein Carbonyls ◽  
High Dose ◽  
Oxidative Stress Biomarkers ◽  
Total Antioxidant ◽  
Dose Oral ◽  
Liver And Kidney ◽  
Mice Liver

Tartrazine is an azo dye which is widely used as colorant in foods, drugs and cosmetics.The aim of this study was to investigate the effect of tartrazine on biochemical and oxidative stress biomarkers on Swiss mice. Tartrazine was administered in drinking water at doses of 0%, 0.005% and 0.05% for 90 days. Both doses of tartrazine declined the body weight gain. In contrary, high dose increased glucose, total cholesterol (TC), triglycerides (TG), LDL, LDL/HDL and CT/HDL, transaminases, total protein (TP), total and direct bilirubin, , urea, creatinine, sodium and potassium levels. However, high dose of tartrazine decreased HDL, chloride, phosphorus and magnesium levels, whereas, tartrazine decreased calcium levels only in female. Both doses of tartrazine declined total antioxidant capacity. Protein carbonyls were in-creased in liver and kidney whith high dose. Liver and kidney superoxide dismutase (SOD) was decreased in male at low and high doses. However, liver SOD was reduced only in female at high dose. Oral administration of tartrazine affects liver and kidney functions as well as induces oxidative stress in mice. So, tartrazine consumption might be harmful to human health. It is necessary that people should be carefully consumed foods containing tartrazine.

scholarly journals Influence of Algae Supplementation on the Concentration of Glutathione and the Activity of Glutathione Enzymes in the Mice Liver and Kidney

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1996
Author(s):  
Grażyna Świderska-Kołacz ◽  
Małgorzata Jefimow ◽  
Jolanta Klusek ◽  
Norbert Rączka ◽  
Szymon Zmorzyński ◽  
...  
Keyword(s):  
Dietary Supplements ◽  
Antioxidant Defense ◽  
Redox System ◽  
Commercial Production ◽  
Protective Properties ◽  
Glutathione Redox System ◽  
Liver And Kidney ◽  
Mice Liver ◽  
Glutathione Enzymes ◽  
Glutathione Redox

Algae are potential and natural source of long-chain polyunsaturated fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The diatom Pinnularia borealis accumulates high levels of EPA and may be considered as a source for commercial production of dietary supplements. In this study we asked the question whether diet supplementation with P. borealis may augment antioxidant defense and ameliorate risk factors for cardiovascular diseases. We fed mice (Mus musculus) with lyophilized diatom solutions of different concentrations (1%, 3%, and 5%) for 7 days. Then we measured glutathione content and the activity of glutathione redox system enzymes, total cholesterol and triacylglycerol concentrations, and malondialdehyde concentration in the liver and kidney. We found that cholesterol and triacylglycerol concentrations in the liver and kidneys were the lowest in mice who were fed with the highest concentration of Pinnularia borealis, suggesting protective properties of algae. Additionally, the lowest concentration of Pinnularia borealis was sufficient to improve antioxidant capacity. Our results suggest that P. borealis may be used as a source for dietary supplements rich in EPA, but the amount supplied to the organism should be limited.

Sign in / Sign up

Export Citation Format

Share Document