scholarly journals High fat-diet and saturated fatty acid palmitate inhibits IGF-1 function in chondrocytes

2017 ◽  
Vol 25 (9) ◽  
pp. 1516-1521 ◽  
Author(s):  
S.A. Nazli ◽  
R.F. Loeser ◽  
S. Chubinskaya ◽  
J.S. Willey ◽  
R.R. Yammani
Keyword(s):  
Fatty Acid ◽  
Saturated Fatty Acid ◽  
High Fat Diet ◽  
High Fat

scholarly journals Saturated Fatty Acid Increases Lung Macrophages and Augments House Dust Mite-Induced Airway Inflammation in Mice Fed with High-Fat Diet

Inflammation ◽  
2017 ◽  
Vol 40 (3) ◽  
pp. 1072-1086 ◽  
Author(s):  
Hiroki Tashiro ◽  
Koichiro Takahashi ◽  
Hironori Sadamatsu ◽  
Go Kato ◽  
Keigo Kurata ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Airway Inflammation ◽  
Saturated Fatty Acid ◽  
House Dust ◽  
House Dust Mite ◽  
High Fat Diet ◽  
High Fat ◽  
Lung Macrophages ◽  
Dust Mite

scholarly journals Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats

2006 ◽  
Vol 95 (5) ◽  
pp. 947-954 ◽  
Author(s):  
Claudio A. Bernal ◽  
Jordi Rovira ◽  
Maryé E. Colandré ◽  
Roser Cussó ◽  
Joan A. Cadefau
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Glucose Metabolism ◽  
Saturated Fatty Acid ◽  
High Fat Diet ◽  
Saturated Fatty Acids ◽  
Control Group ◽  
High Fat ◽  
Glucose Metabolites ◽  
Intracellular Glucose

The aim of the present study was to examine whether the level of dietary cis fatty acid (c FA), or the isomers (trans or cis) and/or the saturation of the fatty acids at high dietary fat levels altered the intracellular glucose metabolites and certain regulatory enzyme activities in the skeletal muscle and liver of rats. The animals were fed for 30 d on either a recommended control diet (7% c FA, w/w) or a high-fat diet (20% fatty acids, w/w). The high-fat diet was enriched with either c FA, trans fatty acid (t FA), a moderate proportion of saturated fatty acid (MSFA), or a high proportion of saturated fatty acid (HSFA). The most striking findings were observed in the gastrocnemius muscle with a HSFA diet. There was a significant increase in glucose-6-phosphate (306 %), glucose-1-phosphate (245 %), fructose-6-phosphate (400 %), fructose-1,6-bisphosphate (86 %), glyceraldehyde- 3-phosphate (38 %), pyruvate (341 %), lactate (325 %), citrate (79 %) and the bisphosphorylated sugars as compared with the cFA diet. These changes were paralleled by an increase in muscle triacylglycerol content (49 %) and a decrease in glucose (39 %). In addition, the amount of cFA and the other types of fatty acid (i.e. t FA and MSFA) led to no great differences in glucose metabolism as compared with the respective control group. These data support the hypothesis that glucose changes induced by a HSFA diet are a multifaceted abnormality. Glucose and lactate transport and intracellular glucose metabolism could be the key biochemical defects involved in this detrimental effect on glucose metabolism.

scholarly journals Intrarenal renin-angiotensin system mediates fatty acid-induced ER stress in the kidney

2016 ◽  
Vol 310 (5) ◽  
pp. F351-F363 ◽  
Author(s):  
Chunling Li ◽  
Yu Lin ◽  
Renfei Luo ◽  
Shaoming Chen ◽  
Feifei Wang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Fatty Acid ◽  
Angiotensin Ii ◽  
Er Stress ◽  
Saturated Fatty Acid ◽  
High Fat Diet ◽  
Renin Angiotensin System ◽  
High Fat ◽  
Angiotensin System ◽  
Ras Activation

Obesity-related kidney disease is related to caloric excess promoting deleterious cellular responses. Accumulation of saturated free fatty acids in tubular cells produces lipotoxicity involving significant cellular dysfunction and injury. The objectives of this study were to elucidate the role of renin-angiotensin system (RAS) activation in saturated fatty acid-induced endoplasmic reticulum (ER) stress in cultured human proximal tubule epithelial cells (HK2) and in mice fed with a high-fat diet. Treatment with saturated fatty acid palmitic acid (PA; 0.8 mM) for 24 h induced ER stress in HK2, leading to an unfolded protein response as reflected by increased expressions of the ER chaperone binding immunoglobulin protein (BiP) and proapoptotic transcription factor C/EBP homologous protein (CHOP) protein as evaluated by immunoblotting. PA treatment also induced increased protein expression of inositol requiring protein 1α (IRE1α), phosphorylated eukaryotic initiation factor-α (eIF2α), and activating transcription factor 4 (ATF4) as well as activation of caspase-3. PA treatment was associated with increased angiotensin II levels in cultured medium. The angiotensin II type 1 receptor (AT1R) blocker valsartan or renin inhibitor aliskiren dramatically suppressed PA-induced upregulation of BiP, CHOP, IRE1α, p-eIF2α, and ATF4 in HK2 cells. In contrast, valsartan or aliskiren did not prevent ER stress induced by tunicamycin. C57BL/6 mice fed with a high-fat diet for 14 wk exhibited increased protein expressions of BiP and CHOP compared with control mice, which were significantly attenuated by the valsartan treatment. Increased angiotensin II levels in serum and urine were observed in mice fed with a high-fat diet when compared with controls. It is suggested that the intrarenal RAS activation may play an important role in diabetic kidney injury via mediating ER stress induced by saturated fatty acid.

scholarly journals Effect of a high fat diet on lipid absorption and fatty acid transport in a rat model of short bowel syndrome

2003 ◽  
Vol 19 (5) ◽  
pp. 385-390 ◽  
Author(s):  
Igor Sukhotnik ◽  
A. Semih Gork ◽  
Min Chen ◽  
Robert A. Drongowski ◽  
Arnold G. Coran ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Short Bowel Syndrome ◽  
Rat Model ◽  
High Fat Diet ◽  
Lipid Absorption ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
High Fat ◽  
Short Bowel

scholarly journals Molecular adaptation in adipose tissue in response to overfeeding with a high-fat diet under sedentary conditions in South Asian and Caucasian men

2019 ◽  
Vol 122 (03) ◽  
pp. 241-251
Author(s):  
Siti N. Wulan ◽  
Freek G. Bouwman ◽  
Klaas R. Westerterp ◽  
Edwin C. M. Mariman ◽  
Guy Plasqui
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
South Asian ◽  
High Fat Diet ◽  
South Asians ◽  
Molecular Adaptation ◽  
Body Fat Percentage ◽  
High Fat ◽  
Fat Percentage ◽  
Caucasian Men

AbstractFor the same BMI, South Asians have a higher body fat percentage than Caucasians. There might be differences in the fatty acid (FA) handling in adipose tissue when both ethnicities are exposed to high-fat overfeeding. The objective of the present study was to investigate the molecular adaptation in relation to FA metabolism in response to overfeeding with a high-fat diet (OHFD) in South Asian and Caucasian men. Ten South Asian men (BMI 18–29 kg/m2) and ten Caucasian men (BMI 22–33 kg/m2), matched for body fat percentage, aged 20–40 years were included. A weight-maintenance diet (30 % fat, 55 % carbohydrate and 15 % protein) was given for 3 d followed by 3 d of overfeeding (150 % energy requirement) with a high-fat diet (60 % fat, 25 % carbohydrate and 15 % protein) while staying in a respiration chamber. Before and after overfeeding, abdominal subcutaneous fat biopsies were taken. Proteins were isolated, analysed and quantified for short-chain 3-hydroxyacyl-CoA dehydrogenase (HADH), carnitine palmitoyl-transferase 1α (CPT1a), adipose TAG lipase, perilipin A (PLINA), perilipin B, lipoprotein lipase and fatty acid binding protein 4 using Western blotting. OHFD decreased the HADH level (P < 0·05) in Caucasians more than in Asians (P < 0·05), but the baseline and after intervention HADH level was relatively higher in Caucasians. The level of CPT1a decreased in South Asians and increased in Caucasians (P < 0·05). PLINA did not change with diet but the level was higher in South Asians (P < 0·05). The observed differences in HADH and PLINA levels as well as in CPT1a response may be important for differences in the long-term regulation of energy (fat) metabolism in these populations.

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