Reduction of Plasma Triglycerides and Cholesterol in High Fat Diet-Induced Hyper-Lipidemic Mice by n-3 Fatty Acid from Bokbunja (Rubus coreanus Miquel) Seed Oil

2015 ◽  
Vol 44 (7) ◽  
pp. 961-969 ◽  
Author(s):  
Hyelin Jeon ◽  
Su-Jin Oh ◽  
Hyun Soo Nam ◽  
Yoon Seok Song ◽  
Kyung-Chul Choi
Keyword(s):  
Fatty Acid ◽  
High Fat Diet ◽  
Seed Oil ◽  
High Fat ◽  
Rubus Coreanus ◽  
Plasma Triglycerides ◽  
Rubus Coreanus Miquel

Blood Flow Improvement Effect of Bokbunja (Rubus coreanus) Seed Oil in High-Fat Diet-Fed Mouse Model

2015 ◽  
Vol 44 (8) ◽  
pp. 1105-1113
Author(s):  
Hyelin Jeon ◽  
Sungmin Kwak ◽  
Su-Jin Oh ◽  
Hyun Soo Nam ◽  
Doo Won Han ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mouse Model ◽  
High Fat Diet ◽  
Seed Oil ◽  
High Fat ◽  
Rubus Coreanus ◽  
Improvement Effect ◽  
Flow Improvement

Anti-Obesity Effects on Unripe Rubus coreanus Miquel Extract in High Fat Diet-Induced Obese Mice

2015 ◽  
Vol 5 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Myung Jung ◽  
Sook-Hyun Cho ◽  
Sun Lee ◽  
Ji Kim ◽  
Young-Suk Kim ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Rubus Coreanus ◽  
Rubus Coreanus Miquel

scholarly journals Health Benefits of Dietary Tree Peony Seed Oil in a High Fat Diet Hamster Model

2017 ◽  
Vol 7 (2) ◽  
pp. 135
Author(s):  
Zhiqiang Zheng ◽  
Jigang Han ◽  
Yingyi Mao ◽  
Xue Tang ◽  
Yan Guan ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Hepatic Steatosis ◽  
High Fat Diet ◽  
Seed Oil ◽  
Unsaturated Fatty Acids ◽  
Health Benefits ◽  
High Fat ◽  
Tree Peony ◽  
Edible Plant

Background: Tree peony (Paeonia ostii) seed oil is rich in different unsaturated fatty acids, including monounsaturated fatty acids (MUFA), n-3 and n-6 polyunsaturated fatty acids (PUFA). Health benefits of this edible plant oil as a whole are barely known yet. In this study, we experimentally investigated benefits of dietary tree peony seed oil (PSO) in dyslipidemia-associated metabolic diseases using a high fat diet hamster model.Methods: High fat diets (HFD) containing 15 % coconut oil (CO) or PSO were first developed based on the rodent chow diet. Fatty acid profiles of diets and red blood cells (RBC) from animals fed these diets for 8 weeks were analyzed and compared. Effects of these oil supplements on triglycerides and cholesterol levels were characterized. Benefits on fatty liver progress were also investigated in this animal model.  Results: HFD fortified with 15% PSO was abundant in different unsaturated fatty acids, containing 40% α-linolenic acid, 27% linoleic acid and 23% oleic acid, respectively. Compared to the control group with 15% CO, animals with 15% PSO displayed dramatic alteration of in vivo fatty acid profile in RBC, featured with a significant increase in n-3 but no change in n-6 PUFA, resulting in decreased ratio of n-6 to n-3 PUFA. PSO intervention also remarkably reduced triglyceride levels in both blood and adipose tissues, while did not affect circulating cholesterol. Moreover, benefits on liver health were observed in the PSO group, evidenced with reduced hepatic steatosis and improved hepatic histology. Conclusion: These data altogether demonstrated multifaceted benefits of dietary PSO in reducing important risk factors of dyslipidemia-associated cardiovascular and liver diseases.Keywords: Peony seed oil, High fat diet, Triglyceride, Cholesterol, Hepatic steatosis

scholarly journals Effect of a high fat diet on lipid absorption and fatty acid transport in a rat model of short bowel syndrome

2003 ◽  
Vol 19 (5) ◽  
pp. 385-390 ◽  
Author(s):  
Igor Sukhotnik ◽  
A. Semih Gork ◽  
Min Chen ◽  
Robert A. Drongowski ◽  
Arnold G. Coran ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Short Bowel Syndrome ◽  
Rat Model ◽  
High Fat Diet ◽  
Lipid Absorption ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
High Fat ◽  
Short Bowel

scholarly journals Molecular adaptation in adipose tissue in response to overfeeding with a high-fat diet under sedentary conditions in South Asian and Caucasian men

2019 ◽  
Vol 122 (03) ◽  
pp. 241-251
Author(s):  
Siti N. Wulan ◽  
Freek G. Bouwman ◽  
Klaas R. Westerterp ◽  
Edwin C. M. Mariman ◽  
Guy Plasqui
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
South Asian ◽  
High Fat Diet ◽  
South Asians ◽  
Molecular Adaptation ◽  
Body Fat Percentage ◽  
High Fat ◽  
Fat Percentage ◽  
Caucasian Men

AbstractFor the same BMI, South Asians have a higher body fat percentage than Caucasians. There might be differences in the fatty acid (FA) handling in adipose tissue when both ethnicities are exposed to high-fat overfeeding. The objective of the present study was to investigate the molecular adaptation in relation to FA metabolism in response to overfeeding with a high-fat diet (OHFD) in South Asian and Caucasian men. Ten South Asian men (BMI 18–29 kg/m2) and ten Caucasian men (BMI 22–33 kg/m2), matched for body fat percentage, aged 20–40 years were included. A weight-maintenance diet (30 % fat, 55 % carbohydrate and 15 % protein) was given for 3 d followed by 3 d of overfeeding (150 % energy requirement) with a high-fat diet (60 % fat, 25 % carbohydrate and 15 % protein) while staying in a respiration chamber. Before and after overfeeding, abdominal subcutaneous fat biopsies were taken. Proteins were isolated, analysed and quantified for short-chain 3-hydroxyacyl-CoA dehydrogenase (HADH), carnitine palmitoyl-transferase 1α (CPT1a), adipose TAG lipase, perilipin A (PLINA), perilipin B, lipoprotein lipase and fatty acid binding protein 4 using Western blotting. OHFD decreased the HADH level (P < 0·05) in Caucasians more than in Asians (P < 0·05), but the baseline and after intervention HADH level was relatively higher in Caucasians. The level of CPT1a decreased in South Asians and increased in Caucasians (P < 0·05). PLINA did not change with diet but the level was higher in South Asians (P < 0·05). The observed differences in HADH and PLINA levels as well as in CPT1a response may be important for differences in the long-term regulation of energy (fat) metabolism in these populations.

The effects of fish oil consumption on cardiovascular remodeling in ApoE deficient mice

2013 ◽  
Vol 91 (11) ◽  
pp. 960-965 ◽  
Author(s):  
Kelby Cleverley ◽  
Xiaozhou Du ◽  
Sheena Premecz ◽  
Khuong Le ◽  
Matthew Zeglinski ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Fatty Acid ◽  
Fish Oil ◽  
High Fat Diet ◽  
Cardiovascular Effects ◽  
Left Ventricular ◽  
Omega 3 ◽  
High Fat ◽  
Omega 3 Fatty Acid ◽  
Deficient Mice

Owing to their spontaneous development of atherosclerosis, apolipoprotein E knockout mice (ApoEKO) are one of the best studied animal models for this disease. Little is known about the utility of various omega-3 fatty acid regimens, in particular fish oils, in preventing cardiac disease in ApoEKO mice. The purpose of this study was to determine the cardiovascular effects of omega-3 fatty acid supplementation with either safflower oil (control), fish oil, flaxseed oil, or designed oil in ApoEKO mice fed a high-fat diet for a total of 16 weeks. In-vivo cardiac function was assessed weekly using murine echocardiography. Blood pressure, plasma lipid levels, and brain natriuretic peptide (BNP) were serially measured. The results show that ApoEKO mice fed fish oil demonstrated an increase in left ventricular wall thickness as a result of increased afterload. Despite chronic treatment with fish oil over 16 weeks, blood pressure increased in ApoEKO mice by 20% compared with the baseline. Both echocardiographic evidence of left ventricular hypertrophy and biochemical increase in BNP levels confirmed diastolic dysfunction in ApoEKO mice fed fish oil. This suggests that high-fat diet supplemented with fish oil may lead to adverse cardiovascular effects in ApoE deficient mice.

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