Heart-Related Quality of Life Among Patients Receiving Standard Heart Failure Care: Predictors and Assessment of Change Over Time (315-A)

This descriptive and exploratory study analyzed variables associated with health-related quality of life among 130 outpatients. Health-related quality of life was measured through the Minnesota Living with Heart Failure Questionnaire. Significant associations were found between patients’ health-related quality of life and their age (r=-0.177; p=0.044), vitality (r=-0.625; p=<0.001) as well as mental health (r=-0.672; p=<0.001), which are both SF-36 domains. The linear regression showed that heart failure symptom severity, vitality and mental health explained 54% of HRQOL measurement variation. To control symptoms and preserve good mental well-being are important to maintain health-related quality of life and to deliver effective heart failure care.

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Change of Health‐Related Quality of Life Over Time and Its Association With Patient Outcomes in Patients With Heart Failure

Journal of the American Heart Association ◽

10.1161/jaha.120.017278 ◽

2020 ◽

Vol 9 (17) ◽

Author(s):

Nariman Sepehrvand ◽

Anamaria Savu ◽

John A. Spertus ◽

Jason R. B. Dyck ◽

Todd Anderson ◽

...

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Ejection Fraction ◽

Summary Score ◽

Health Related Quality ◽

Reduced Ejection Fraction ◽

Related Quality ◽

Health Related ◽

Over Time

Background Improving health‐related quality of life is an important goal in the management of patients with heart failure (HF). Defining health‐related quality of life changes over time in patients with HF with preserved (HFpEF) or reduced ejection fraction and showing their association with other important clinical events could support the use of health‐related quality of life as a measure of quantifying HF care. Methods and Results In the Alberta HEART (Heart Failure Aetiology and Analysis Team) cohort (n=621), patients were categorized into 4 subgroups: healthy controls (n=98), at risk (n=163), HFpEF (n=191), and HF with reduced ejection fraction (n=169). The change of the Kansas City Cardiomyopathy Questionnaire (KCCQ), EuroQOL 5 dimensions, and Functional Assessment of Cancer Therapy—Anemia over 12 months, and its association with a composite of death or rehospitalization within 3 years were assessed. At baseline, the KCCQ overall summary score was 73 (interquartile range, 53–86) in HFpEF and 78 (interquartile range, 56–90) in HF with reduced ejection fraction ( P =0.22). Overall, 30.5% of patients with HF experienced ≥5‐point improvements and 32.4% had ≥5‐point worsening in KCCQ overall summary score at 12 months, which did not differ between HFpEF and HF with reduced ejection fraction ( P =0.23). Clinical events were higher in patients with HF who had a decline in KCCQ over 12 months as compared with those with stable KCCQ scores (70.2% versus 52.0%, P =0.012). The results were similar for the Functional Assessment of Cancer Therapy—Anemia and EuroQOL 5 dimensions. Conclusions In patients with HF, the KCCQ quantified clinically meaningful changes over time, which were associated with important clinical outcomes in patients with HFpEF. Given the observed variability and prognostication in different patient trajectories, health‐related quality of life measures could be valuable for quantifying the quality of care in healthcare systems.

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Burning mouth syndrome and oral health-related quality of life: is there a change over time?

Oral Diseases ◽

10.1111/j.1601-0825.2010.01666.x ◽

2010 ◽

Vol 16 (7) ◽

pp. 643-647 ◽

Cited By ~ 21

Author(s):

R Ni Riordain ◽

E Moloney ◽

K O’Sullivan ◽

C McCreary

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Burning Mouth Syndrome ◽

Health Related Quality ◽

Change Over Time ◽

Related Quality ◽

Health Related ◽

Burning Mouth ◽

Over Time

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Author Correction: Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients

Scientific Reports ◽

10.1038/s41598-020-60489-2 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Ivano Riva ◽

◽

Lorenzo Legramandi ◽

Eliana Rulli ◽

Anastasios G. Konstas ◽

...

Keyword(s):

Quality Of Life ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Newly Diagnosed ◽

Symptom Perception ◽

Change Over Time ◽

Related Quality ◽

Over Time

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P139 What impact does JIA have on health-related quality of life over time and by gender?

Rheumatology ◽

10.1093/rheumatology/keaa111.134 ◽

2020 ◽

Vol 59 (Supplement_2) ◽

Author(s):

Andrew Smith ◽

Bishma Saqib ◽

Rebecca Lee ◽

Wendy Thomson ◽

Lis Cordingley

Keyword(s):

Quality Of Life ◽

Health Status ◽

Child Health ◽

Reference Population ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Over Time ◽

Domain Scores

Abstract Background Juvenile idiopathic arthritis (JIA) is a heterogeneous group of arthritic conditions presenting in children and young people, in which physical limitations and associated complications can have detrimental effects on physical and psychosocial wellbeing. This study aims to investigate the impact of living with JIA on different aspects of health-related quality of life (HRQoL) and to explore how this changes over time, using data from the Childhood Arthritis Prospective Study (CAPS). Methods Longitudinal data collected as part of CAPS were analysed. HRQoL was assessed at baseline, 1 year and 3 years’ post-diagnosis using the Child Health Questionnaire (CHQ), a parent-completed form for children from 5 years of age. The CHQ measures physical, emotional and social components of child health status. Raw domain scores were transformed via algorithm into values ranging from 0-100, with higher scores indicating better health status. Mean (standard deviation) and median (interquartile range) for each domain were determined, both for the full cohort and by gender. Differences between median scores at baseline and 3 years were assessed using the Wilcoxon signed-rank test. Mean scores of each domain were visually compared with a reference population sample of healthy children from the United States. Results 184 participants completed the questionnaire at all 3 time points. At baseline, compared to the reference population, children with JIA scored lower in every domain although scores were closer between the 2 groups at 3 years. Median scores improved over time, the exception being the general health perceptions domain which decreased after baseline. Domains with the greatest improvement were physical functioning,“bodily pain and social-physical. The largest changes occurred from baseline to 1 year. Statistically significant differences between baseline and 3-year scores were found for all domains. Domain scores for male and female participants were very similar at baseline, though scores for male participants indicated slightly better health at 1 and 3 years for both physical and psychosocial domains. Conclusion JIA has significant impact on HRQoL, which improves within 3 years of diagnosis with the greatest improvement occurring within the first year. Physical health domains show greater improvement over time than psychosocial domains, although psychosocial scores were generally higher throughout the study. Male participants tend to score slightly higher than female participants in both physical and psychosocial domains after baseline. Further research should explore measurable patient, age or disease-related drivers of HRQoL. Disclosures A. Smith None. B. Saqib None. R. Lee None. W. Thomson None. L. Cordingley None.

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Health‐related quality of life maintained over time in patients with relapsed or refractory multiple myeloma treated with daratumumab in combination with bortezomib and dexamethasone: results from the phase III CASTOR trial

British Journal of Haematology ◽

10.1111/bjh.17321 ◽

2021 ◽

Author(s):

Vania Hungria ◽

Meral Beksac ◽

Katja C. Weisel ◽

Ajay K. Nooka ◽

Tamas Masszi ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Myeloma ◽

Phase Iii ◽

Health Related Quality ◽

Refractory Multiple Myeloma ◽

Related Quality ◽

Health Related ◽

Over Time

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Impact of malnutrition on health-related quality of life in persons receiving dialysis: a prospective study

British Journal Of Nutrition ◽

10.1017/s000711452100249x ◽

2021 ◽

pp. 1-24

Author(s):

Daniela Viramontes-Hörner ◽

Zoe Pittman ◽

Nicholas M Selby ◽

Maarten W Taal

Keyword(s):

Quality Of Life ◽

Prospective Study ◽

Health Related Quality ◽

Poor Hrqol ◽

Sf 36 ◽

Related Quality ◽

Health Related ◽

The Impact ◽

Over Time

Abstract Health-related quality of life (HRQoL) is severely impaired in persons receiving dialysis. Malnutrition has been associated with some measures of poor HRQoL in cross-sectional analyses in dialysis populations, but no studies have assessed the impact of malnutrition and dietary intake on change in multiple measures of HRQoL over time. We investigated the most important determinants of poor HRQoL and the predictors of change in HRQoL over time using several measures of HRQoL. We enrolled 119 haemodialysis and 31 peritoneal dialysis patients in this prospective study. Nutritional assessments (Subjective Global Assessment [SGA], anthropometry and 24-hour dietary recalls) and HRQoL questionnaires (Short Form-36 [SF-36] mental [MCS] and physical component scores [PCS] and European QoL-5 Dimensions [EQ5D] health state [HSS] and visual analogue scores [VAS]) were performed at baseline, 6 and 12 months. Mean age was 64(14) years. Malnutrition was present in 37% of the population. At baseline, malnutrition assessed by SGA was the only factor independently (and negatively) associated with all four measures of HRQoL. No single factor was independently associated with decrease in all measures of HRQoL over 1 year. However, prevalence/development of malnutrition over one year was an independent predictor of 1-year decrease in EQ5D HSS and 1-year decrease in fat intake independently predicted the 1-year decline in SF-36 MCS and PCS, and EQ5D VAS. These findings strengthen the importance of monitoring for malnutrition and providing nutritional advice to all persons on dialysis. Future studies are needed to evaluate the impact of nutritional interventions on HRQoL and other long-term outcomes.

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