Abdominal Pain-Associated Functional Gastrointestinal Disorder Prevalence in Children and Adolescents with Celiac Disease on Gluten-Free Diet: A Multinational Study

Introduction/Objective. Nonclassical celiac disease (CD) is characterized by a very heterogeneous and non-specific clinical presentation. The aim of this study was to determine the basic symptoms and clinical signs of this CD subtype in children and adolescents Methods. The study was based on a sample of 58 children and adolescent, 38 female and 20 male, ages 1.75 to 17.75 (10.01 ? 4.62) years with a nonclassical CD diagnosed according to the ESPGHAN criteria from 1990 and 2012. Results. Except four patients who were between the ages of 1.75 to 2.50 years, all others were older than three years. The main clinical symptoms and signs suggestive of non-classical CB were anemia caused by iron deficiency (48.28%), short stature (34.48%), and intermittent abdominal pain (18.97%), anorexia with stagnation or weight loss (13.79%), and chronic constipation (6.90%). One symptom or a sign of the disease had 30 patients, 15 two and 13 three. In addition, 12 patients had dental enamel hypoplasia, 18 sideropenia without anemia and 5 mild isolated hypertransaminasemia. A gluten-free diet, apart from the dental enamel hypoplasia, has resulted in the withdrawal of all indicators of the disease. Conclusion. The main symptoms and clinical signs of nonclassical CD in children and adolescents were iron deficiency anemia, short stature and intermittent abdominal pain, and less frequently anorexia with stagnation or weight loss and chronic constipation. Excluding dental enamel hypoplasia, a gluten-free diet leads to a complete recovery of the patient.

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Social Aspects of Adherence to Gluten-Free Diet for Children and Adolescents with Celiac Disease

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) ◽

10.21508/1027-4065-2020-65-6-57-64 ◽

2021 ◽

Vol 65 (6) ◽

pp. 57-64

Author(s):

I. N. Zakharova ◽

L. Ja. Klimov ◽

L. D. Kochneva ◽

M. G. Gevandova ◽

V. A. Kuryaninova ◽

...

Keyword(s):

Celiac Disease ◽

Children And Adolescents ◽

Social Problems ◽

Dietary Habits ◽

Social Issues ◽

Gluten Free Diet ◽

Gluten Free ◽

Free Products ◽

Strict Adherence ◽

Factors Affecting

The purpose of the study: analysis of medical and social problems and factors affecting the availability and compliance of a gluten-free diet, based on a survey of parents of children with celiac disease living in southern Russia. Purpose of the Study: Analysis of the medical and social problems and factors affecting the availability and adherence to the gluten-free diet based on the results of the questioning survey of the parents of children with celiac disease that are residents of the south of Russia. Children Characteristics and Study Methods. The study include 200 families that bring up the children with the celiac disease at the ages from 10 months to 18 years. The patients included 116 (58%) girls and 84 (42%) boys. The medical and social issues were studied using the developed questionnaire consisting of the open questions and intended as self-administered by the patient parents. Results. 87% of the families noted the significant difficulties in adhering to the diet, 75% were forced to refuse to travel with children, 56% of the surveyed were unable to visit the public spaces, restaurants, and 90% indicated the impossibility and difficulties in purchase of the gluten-free products. The strict adherence to the diet at school age is much worse. The main reasons for the deliberate non- adherence to the gluten-free diet are the high cost of food, lack of funds to purchase it. The patient families spend RUB 8,000– 9,000 per month in average to purchase the gluten-free products. There is a great demand of patients for the imported products with the relevant quality marks. The psychological symptoms were noted in the patients with celiac disease in response to the introduction of the gluten-free diet, manifested by the depression, aggression, irritability, high level of the anxiety. Conclusion. The main difficulties faced by the families that bring up the children and adolescents with the celiac disease include the social and psychological maladjustment of the patients, reduced finances, search and purchase of the high-quality gluten-free products and the necessity to adapt the child and family members to the dietary habits.

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Reversal of low bone density with a gluten-free diet in children and adolescents with celiac disease

American Journal of Clinical Nutrition ◽

10.1093/ajcn/67.3.477 ◽

1998 ◽

Vol 67 (3) ◽

pp. 477-481 ◽

Cited By ~ 89

Author(s):

S Mora ◽

G Barera ◽

A Ricotti ◽

G Weber ◽

C Bianchi ◽

...

Keyword(s):

Celiac Disease ◽

Bone Density ◽

Children And Adolescents ◽

Gluten Free Diet ◽

Gluten Free ◽

Low Bone Density

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A Randomized, Placebo-Controlled, Pilot Clinical Trial to Evaluate the Effect of Supplementation with Prebiotic Synergy 1 on Iron Homeostasis in Children and Adolescents with Celiac Disease Treated with a Gluten-Free Diet

Nutrients ◽

10.3390/nu10111818 ◽

2018 ◽

Vol 10 (11) ◽

pp. 1818 ◽

Cited By ~ 7

Author(s):

Klaudia Feruś ◽

Natalia Drabińska ◽

Urszula Krupa-Kozak ◽

Elżbieta Jarocka-Cyrta

Keyword(s):

Celiac Disease ◽

Children And Adolescents ◽

Iron Homeostasis ◽

Blood Parameters ◽

Gluten Free Diet ◽

Deficiency Anemia ◽

Gluten Free ◽

Significant Difference ◽

Before And After ◽

Serum Hepcidin

Iron deficiency anemia (IDA) occurs in 15–46% of patients with celiac disease (CD), and in some cases, it may be its only manifestation. Studies in animal models have shown that prebiotics, including inulin, may help to increase intestinal absorption of iron. The aim of this study was to evaluate the effect of a prebiotic, oligofructose-enriched inulin (Synergy 1), on iron homeostasis in non-anemic children and adolescents with celiac disease (CD) in association with a gluten-free diet (GFD). Thirty-four CD patients (4–18 years old) were randomized into two groups receiving Synergy 1 (10 g/day) or a placebo (maltodextrin) for three months. Before and after intervention, blood samples were collected from all patients for assessment of blood morphology, biochemical parameters and serum hepcidin concentration. We found that serum hepcidin concentration after the intervention was significantly decreased by 60.9% (p = 0.046) in the Synergy 1 group, whereas no significant difference was observed in the placebo group. No differences in morphological and biochemical blood parameters (including ferritin, hemoglobin and C-reactive protein (CRP)) were observed after intervention in either group. Given that hepcidin decrease may improve intestinal iron absorption, these results warrant further investigation in a larger cohort and especially in patients with IDA.

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PO31 WORRIES AND NEEDS IN CHILDREN AND ADOLESCENTS WITH CELIAC DISEASE. ADHERENCE TO GLUTEN-FREE DIET. IMPLICATIONS FOR CLINICAL PRACTICE

Digestive and Liver Disease ◽

10.1016/s1590-8658(12)60695-1 ◽

2012 ◽

Vol 44 ◽

pp. S271-S272

Author(s):

S. Battistutta ◽

S. Martelossi ◽

C. Cervesi ◽

M. Montico ◽

M. Bin ◽

...

Keyword(s):

Celiac Disease ◽

Clinical Practice ◽

Children And Adolescents ◽

Gluten Free Diet ◽

Gluten Free

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The Profile of Urinary Headspace Volatile Organic Compounds After 12-Week Intake of Oligofructose-Enriched Inulin by Children and Adolescents with Celiac Disease on a Gluten-Free Diet: Results of a Pilot, Randomized, Placebo-Controlled Clinical Trial

Molecules ◽

10.3390/molecules24071341 ◽

2019 ◽

Vol 24 (7) ◽

pp. 1341 ◽

Cited By ~ 2

Author(s):

Natalia Drabińska ◽

Elżbieta Jarocka-Cyrta ◽

Norman Ratcliffe ◽

Urszula Krupa-Kozak

Keyword(s):

Celiac Disease ◽

Volatile Organic Compounds ◽

Children And Adolescents ◽

Organic Compounds ◽

Gluten Free Diet ◽

Urine Samples ◽

Whole Body ◽

Gluten Free ◽

Functional Impairments ◽

Volatile Organic

The concentration of volatile organic compounds (VOCs) can inform about the metabolic condition of the body. In the small intestine of untreated persons with celiac disease (CD), chronic inflammation can occur, leading to nutritional deficiencies, and consequently to functional impairments of the whole body. Metabolomic studies showed differences in the profile of VOCs in biological fluids of patients with CD in comparison to healthy persons; however, there is scarce quantitative and nutritional intervention information. The aim of this study was to evaluate the effect of the supplementation of a gluten-free diet (GFD) with prebiotic oligofructose-enriched inulin (Synergy 1) on the concentration of VOCs in the urine of children and adolescents with CD. Twenty-three participants were randomized to the group receiving Synergy 1 (10 g per day) or placebo for 12 weeks. Urinary VOCs were analyzed using solid-phase microextraction and gas chromatography–mass spectrometry. Sixteen compounds were identified and quantified in urine samples. The supplementation of GFD with Synergy 1 resulted in an average concentration drop (36%) of benzaldehyde in urine samples. In summary, Synergy 1, applied as a supplement of GFD for 12 weeks had a moderate impact on the VOC concentrations in the urine of children with CD.

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