scholarly journals Clinical features of non-classical celiac disease in children and adolescents

2020 ◽  
pp. 70-70
Author(s):  
Nedeljko Radlovic ◽  
Zoran Lekovic ◽  
Vladimir Radlovic ◽  
Jelena Mandic ◽  
Marija Mladenovic ◽  
...  
Keyword(s):  
Weight Loss ◽  
Abdominal Pain ◽  
Celiac Disease ◽  
Children And Adolescents ◽  
Clinical Signs ◽  
Dental Enamel ◽  
Gluten Free ◽  
Enamel Hypoplasia ◽  
Intermittent Abdominal Pain ◽  
Dental Enamel Hypoplasia

Introduction/Objective. Nonclassical celiac disease (CD) is characterized by a very heterogeneous and non-specific clinical presentation. The aim of this study was to determine the basic symptoms and clinical signs of this CD subtype in children and adolescents Methods. The study was based on a sample of 58 children and adolescent, 38 female and 20 male, ages 1.75 to 17.75 (10.01 ? 4.62) years with a nonclassical CD diagnosed according to the ESPGHAN criteria from 1990 and 2012. Results. Except four patients who were between the ages of 1.75 to 2.50 years, all others were older than three years. The main clinical symptoms and signs suggestive of non-classical CB were anemia caused by iron deficiency (48.28%), short stature (34.48%), and intermittent abdominal pain (18.97%), anorexia with stagnation or weight loss (13.79%), and chronic constipation (6.90%). One symptom or a sign of the disease had 30 patients, 15 two and 13 three. In addition, 12 patients had dental enamel hypoplasia, 18 sideropenia without anemia and 5 mild isolated hypertransaminasemia. A gluten-free diet, apart from the dental enamel hypoplasia, has resulted in the withdrawal of all indicators of the disease. Conclusion. The main symptoms and clinical signs of nonclassical CD in children and adolescents were iron deficiency anemia, short stature and intermittent abdominal pain, and less frequently anorexia with stagnation or weight loss and chronic constipation. Excluding dental enamel hypoplasia, a gluten-free diet leads to a complete recovery of the patient.

IMPLICAÇÕES ODONTOLÓGICAS DO ACOMETIMENTO PELA DOENÇA CELÍACA

2020 ◽  
Author(s):  
Sérgio Spezzia
Keyword(s):  
Celiac Disease ◽  
Early Diagnosis ◽  
Dental Enamel ◽  
Enamel Hypoplasia ◽  
Dental Enamel Hypoplasia ◽  
Keywords Celiac Disease ◽  
Intestino Delgado

Resumo Doença celíaca (DC) consta de desordem inflamatória crônica autoimune, que desencadeia reação autoimune na região do intestino delgado. As modificações ocasionadas pela DC na mucosa do intestino delgado possuem reversibilidade, ao passo que orienta-se os pacientes a não ingerir mais alimentação que contenha o glúten. Deve ser adotada também como medida a averiguação das bulas dos remédios, no intuito de verificar se os mesmos contém traços de glúten em sua fórmula. Existem inúmeros pacientes assintomáticos, o que dificulta a determinação diagnóstica e sabe-se que caso não se proceda ao diagnóstico e ao tratamento da DC em tempo hábil pode haver complicações indesejáveis. O objetivo do presente artigo foi averiguar acerca das manifestações bucais ocorridas em pacientes doentes em decorrência da presença da DC. As principais manifestações orais da DC que podem ocorrer envolvem hipossalivação; glossites; defeitos de esmalte; úlceras aftosas recorrentes; estomatites; aftas; manchas por insuficiência ou por excesso de cálcio, dentre outras. O conhecimento e a conscientização prévia pelos cirurgiões dentistas acerca das repercussões bucais acarretadas pela possível presença da DC em seus pacientes é de fundamental importância para o aprimoramento diagnóstico e para a adoção de condutas odontológicas apropriadas. Palavras-chave: Doença Celíaca. Dieta. Diagnóstico Precoce. Hipoplasia do Esmalte Dentário. Keywords: Celiac Disease. Diet. Early Diagnosis. Dental Enamel Hypoplasia.

PA.41 ADULT CELIAC DISEASE AND DENTAL ENAMEL HYPOPLASIA: A CASE CONTROL STUDY

2008 ◽  
Vol 40 ◽  
pp. S90
Author(s):  
S. Segato ◽  
M. Parravicini ◽  
G. Chianese ◽  
L. Frangi ◽  
C. Mirelli
Keyword(s):  
Celiac Disease ◽  
Case Control Study ◽  
Dental Enamel ◽  
Case Control ◽  
Enamel Hypoplasia ◽  
Adult Celiac Disease ◽  
Dental Enamel Hypoplasia ◽  
Control Study

scholarly journals Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region

2007 ◽  
Vol 3 (1) ◽  
Author(s):  
Maurizio Procaccini ◽  
Giuseppina Campisi ◽  
Pantaleo Bufo ◽  
Domenico Compilato ◽  
Claudia Massaccesi ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Central Region ◽  
Case Control Study ◽  
Dental Enamel ◽  
Case Control ◽  
Enamel Hypoplasia ◽  
Dental Enamel Hypoplasia ◽  
Control Study

scholarly journals IMPLICAÇÕES ODONTOLÓGICAS DO ACOMETIMENTO PELA DOENÇA CELÍACA

2020 ◽  
Author(s):  
Sérgio Spezzia
Keyword(s):  
Celiac Disease ◽  
Early Diagnosis ◽  
Dental Enamel ◽  
Enamel Hypoplasia ◽  
Dental Enamel Hypoplasia ◽  
Keywords Celiac Disease ◽  
Intestino Delgado

Resumo Doença celíaca (DC) consta de desordem inflamatória crônica autoimune, que desencadeia reação autoimune na região do intestino delgado. As modificações ocasionadas pela DC na mucosa do intestino delgado possuem reversibilidade, ao passo que orienta-se os pacientes a não ingerir mais alimentação que contenha o glúten. Deve ser adotada também como medida a averiguação das bulas dos remédios, no intuito de verificar se os mesmos contém traços de glúten em sua fórmula. Existem inúmeros pacientes assintomáticos, o que dificulta a determinação diagnóstica e sabe-se que caso não se proceda ao diagnóstico e ao tratamento da DC em tempo hábil pode haver complicações indesejáveis. O objetivo do presente artigo foi averiguar acerca das manifestações bucais ocorridas em pacientes doentes em decorrência da presença da DC. As principais manifestações orais da DC que podem ocorrer envolvem hipossalivação; glossites; defeitos de esmalte; úlceras aftosas recorrentes; estomatites; aftas; manchas por insuficiência ou por excesso de cálcio, dentre outras. O conhecimento e a conscientização prévia pelos cirurgiões dentistas acerca das repercussões bucais acarretadas pela possível presença da DC em seus pacientes é de fundamental importância para o aprimoramento diagnóstico e para a adoção de condutas odontológicas apropriadas. Palavras-chave: Doença Celíaca. Dieta. Diagnóstico Precoce. Hipoplasia do Esmalte Dentário. Keywords: Celiac Disease. Diet. Early Diagnosis. Dental Enamel Hypoplasia.  

scholarly journals Non-Celiac Gluten Sensitivity: A Challenging Diagnosis in Children with Abdominal Pain

2018 ◽  
Vol 73 (Suppl. 4) ◽  
pp. 39-46 ◽  
Author(s):  
Frank M. Ruemmele
Keyword(s):  
Abdominal Pain ◽  
Celiac Disease ◽  
Clinical Symptoms ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Clear Cut ◽  
Clinical Presentations ◽  
New Findings ◽  
Three Phase ◽  
Gi Symptoms

Several disorders related to the ingestion of gluten are well recognized despite overlapping clinical presentations: celiac disease, an autoimmune enteropathy triggered by gluten ingestions in susceptible individuals, allergy to wheat, and more recently non-celiac gluten sensitivity (NCGS). While celiac disease and wheat allergy are well-known disorders with a clear-cut diagnosis based on clinical tests and biological parameters, NCGS is a more difficult diagnosis, especially in children with functional gastrointestinal (GI) complaints. NCGS is considered a syndrome of intestinal but also extraintestinal symptoms occurring within hours, but sometimes even after several days of gluten ingestion. In children, the leading symptoms of NCGS are abdominal pain and diarrhea, while extraintestinal symptoms are rare, in contrast to adult patients. No precise diagnostic test nor specific biomarkers exist, except a rather cumbersome three-phase gluten-exposure, gluten-free diet, followed by a blinded placebo-controlled gluten challenge with crossover to provoke symptoms elicited by gluten in a reproducible manner that disappear on gluten-free alimentation. Recent data indicate that the peptide part of wheat proteins is not necessarily the sole trigger of clinical symptoms. Mono- or oligosaccharides, such as fructan and other constituents of wheat, were able to provoke GI symptoms in clinical trials. These new findings indicate that the term gluten sensitivity is probably too restrictive. The incidence of NCGS was reported in the range of 1–10% in the general population and to increase steadily; however, most data are based on patients’ self-reported gluten intolerance or avoidance without a medically confirmed diagnosis. Treatment consists of gluten avoidance for at least several weeks or months. Patients with NCGS require regular reassessment for gluten tolerance allowing with time the reintroduction of increasing amounts of gluten.

scholarly journals A109 CELIAC DISEASE IS A RARE CAUSE OF BENIGN DUODENAL STRICTURE

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 126-127
Author(s):  
I Balubaid ◽  
N Khanna
Keyword(s):  
Weight Loss ◽  
Celiac Disease ◽  
Case Reports ◽  
Balloon Dilation ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Early Satiety ◽  
Ulcer Disease ◽  
Duodenal Stricture ◽  
H Pylori

Abstract Background Benign duodenal stricture is an uncommon problem encountered by gastroenterologists. The most common cause is peptic ulcer disease (PUD). With the diagnosis and eradication of H. Pylori, early diagnosis of PUD and the use of PPIs to treat upper gastrointestinal inflammation, the incidence of benign duodenal stricture has dramatically decreased. Patients with duodenal stricture may present with early satiety, nausea, vomiting and weight loss. We present the case of a man with a refractory web-like stricture in the second part of the duodenum (D2) caused by Celiac disease. Aims To describe a rare endoscopic finding in a patient with Celiac disease Methods Case report with literature review Results We present a case of a 64 year old male was referred for consideration of duodenal stenting of a refractory stricture in the second part of the duodenum D2. The patient had a 1 year history of abdominal pain, early satiety and weight loss (10 lbs). He also reported intermittent episodes of diarrhea. Investigations included a CT scan of the abdomen which showed a stricture at the level of proximal D2 described as a “duodenal band”. Previous attempts at balloon dilation had not resulted in prolonged symptomatic or endoscopic improvement. Testing for H. Pylori was negative and he did not use NSAIDs. Upper endoscopy was performed to assess the stricture prior to consideration of stenting. This showed a tight web-like stricture in proximal D2. The stricture was balloon dilated up to 16.5 mm, enabling the endoscope to pass beyond it. The mucosa in D2 was atrophic with flattening of the folds and scalloping. There was no inflammation seen. Biopsies from D2 revealed moderate villous blunting and intraepithelial lymphocytosis. Celiac serology testing was abnormal, with an anti-tTG Ab level of 32 RU/ml which confirmed the diagnosis of Celiac disease. The balloon dilation and gluten-free diet resulted in resolution of his symptoms. Follow up endoscopy revealed normalization of his duodenal folds and biopsies. In addition, anti-tTG Ab level was normalized. Although stricture improved with prolonged patency, he still has mild recurrence of his stricture requiring balloon dilation on an annual basis. Conclusions This case describes a very uncommon complication of Celiac disease. The likely pathophysiology involves inflammation and potentially ulceration from Celiac disease, resulting in a benign stricture. There have been a few case reports describing duodenal strictures as a complication of Celiac disease. Treatment involves a gluten-free diet and endoscopic therapy. More severe cases of obstruction would likely require surgical intervention. In our case, the gluten-free diet and balloon dilation were successful and duodenal stenting was not necessary. Given the possibility of Celiac disease as a cause of duodenal stricture, it would be reasonable to biopsy D2 and check anti-tTG Ab in cases of duodenal stricture. Funding Agencies None

Bone mineral density and importance of strict gluten-free diet in children and adolescents with celiac disease

Bone ◽  
2010 ◽  
Vol 47 (3) ◽  
pp. 598-603 ◽  
Author(s):  
Štefan Blazina ◽  
Nevenka Bratanič ◽  
Andreja Širca Čampa ◽  
Rok Blagus ◽  
Rok Orel
Keyword(s):  
Bone Mineral Density ◽  
Celiac Disease ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Mineral Density

The influence of gluten free diet on quantitative ultrasound of proximal phalanxes in children and adolescents with type 1 diabetes mellitus and celiac disease

Bone ◽  
2008 ◽  
Vol 43 (2) ◽  
pp. 322-326 ◽  
Author(s):  
Giuliana Valerio ◽  
Raffaella Spadaro ◽  
Dario Iafusco ◽  
Francesca Lombardi ◽  
Antonio del Puente ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Quantitative Ultrasound ◽  
Gluten Free Diet ◽  
Gluten Free
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