Reinterpretation of Chromosomal Microarrays with Detailed Medical History

2020 ◽  
Vol 222 ◽  
pp. 180-185.e1 ◽  
Author(s):  
Midhat S. Farooqi ◽  
Shirelle Figueroa ◽  
Garrett Gotway ◽  
Jason Wang ◽  
Hung S. Luu ◽  
...  
Keyword(s):  
Medical History ◽  
Detailed Medical History ◽  
Chromosomal Microarrays

Abstract P002: Heavy Alcohol Consumption Increases the Risk of Atrial Fibrillation -Circulatory Risk in Communities Study(CIRCS)

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Fumihiko Sano ◽  
Tetsuya Ohira ◽  
Akihiko Kitamura ◽  
Hironori Imano ◽  
Renzhe Cui ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Medical History ◽  
Moderate Alcohol Consumption ◽  
Heavy Alcohol ◽  
Ethanol Drinking ◽  
Wide Range ◽  
Detailed Medical History ◽  
Heavy Alcohol Consumption

Background— Evidence on the relationship of a wide range of alcohol consumption with risk of incident atrial fibrillation has been limited. Methods— Between 1991 and 1995, 8602 Japanese men and women aged 30 to 80 years and free of clinical atrial fibrillation took part in the first examination of the Circulatory Risk in Communities Study(CIRCS)- a population based cohort study of cardiovascular risk factors, cardiovascular disease incidence, and their trends in Japanese communities. In the first examination, we checked a detailed medical history, physical examination, blood and urine examination, and electrocardiogram (ECG). An interviewer obtained histories in detail for weekly alcohol intake. In the follow-up period, incident atrial fibrillations were ascertained by annual ECG record and medical history of treatment of atrial fibrillation. ECGs were coded with the Minnesota Code by trained physician-epidemiologists. Differences in baseline characteristics between atrial fibrillation cases and controls were compared using Student t-tests or chi-squared tests. The hazard ratios (HRs) of incidence of atrial fibrillation and 95% confidence interval (CI) relative to the never-drinking group were calculated with adjustment for age and other potential confounding factors using the Cox proportional hazard model. Results— During an average follow-up of 6.4 years, 290 incident atrial fibrillation occurred. The higher incidence rate of atrial fibrillation was observed among participants with more than 69 g of ethanol drinking per week, compared with less than 69 g of ethanol drinking per week. On the other hand, light to moderate alcohol consumption was not associated with risk of atrial fibrillation. Compared with the never drinking group, the multivariable-adjusted HRs of past, light (<23 g), light moderate (23-46 g), moderate (46-69 g), and heavy (>69 g) drinking groups were 1.20 (95% CI, 0.61-2.35), 0.85 (95% CI, 0.57-1.27), 1.05 (95% CI, 0.63-1.75), 1.34 (95% CI, 0.78-2.32), and 2.92 (95% CI, 1.61-5.28), respectively. Conclusions— Heavy alcohol consumption was associated with the higher risk of atrial fibrillation, whereas there was no association of less than moderate alcohol consumption and atrial fibrillation.

scholarly journals Behavior of biomarkers during pregnancy and lactation through a biological multi-paradigm model. BECOME study protocol

2016 ◽  
Author(s):  
María José Aguilar-Cordero ◽  
Laura Baena-García ◽  
Raquel Rodríguez-Blanque ◽  
Juan Carlos Sánchez-García ◽  
Manuel Isidoro Capel-Tuñón ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Medical History ◽  
Scientific Development ◽  
Computer Simulation Model ◽  
Sample Collection ◽  
Administrative Preparation ◽  
Healthy Women ◽  
Detailed Medical History ◽  
Pregnancy And Lactation ◽  
Project Objectives

Background Despite of advances in research, at the moment, various points related to the physiology of gestation and the etiology of severe diseases that can be developed in the course of it remain unknown. One of those aspects is the behavior of biomarkers (triglycerides, prolactin, glucose and cholesterol) during pregnancy, which experience a gradual increase in their levels until they reach the peak of hypertriglyceridemia, a few days before delivery. Several studies have reported that biomarkers experience a higher elevation in diabetic and obese pregnant women and in those women who suffer preeclampsia. The description of their behavior in different population of pregnant women (healthy women and women at risk) would identify the relation of these with some of the alterations that occurs more frequently during pregnancy. Objective The aim of this study is to develop a multi-paradigm biological model of systems to determine triglyceride, prolactin, glucose and cholesterol levels during pregnancy and its relation with lactogenesis in healthy and risk pregnant women. Methods A prospective cohort study will take place with women during pregnancy and lactation. Participating women will be divided into two groups. One group will be integrated by healthy women and the other group by pregnant women with a risk medical history. The personal, family and a detailed medical history will be collected in each group. A study of all the variables which influence the level of the mentioned biomarkers (triglycerides, cholesterol, glucose and prolactin) will be done. The universe consists in 4,300 women, who constitute the historical average deliveries during the semester in the city of Granada (Spain). The sample collection will be made in medical office’s pregnancy control in Granada’s hospitals, in their respective health centers and during the second half of 2015. The sample will be stratified and probabilistic. Peculiarities of pregnant women will be taken into account when calculating the size of the study sample. This sample will be made up of 224 women who comply with the inclusion criteria and that have signed the informed consent. To achieve the project objectives an organization comprising six theoretical and practical phases enabling the scientific development of the project. During the first phase, the technical and administrative preparation of the project is constructed. Thereafter, the work is divided into two action areas which encompass the collection and data modeling. The creation of a biological multi-paradigm computer simulation model of the levels of biomarkers in different months of pregnancy and in the various pathologies of pregnant women can be very effective to know the risks that involve high levels of lipids for the mother and for the baby.

scholarly journals Von Willebrand disease as a significant risk factor for hemorrhage after cervical loop electrosurgical excision

2018 ◽  
Vol 7 (7) ◽  
pp. 2926
Author(s):  
Anita Ungure ◽  
Jana Žodžika ◽  
Diāna Kuņicina ◽  
Nellija Lietuviete ◽  
Dace Rezeberga
Keyword(s):  
Medical History ◽  
Significant Risk ◽  
Intraepithelial Neoplasia ◽  
Von Willebrand Disease ◽  
Severe Bleeding ◽  
Acid Therapy ◽  
Surgical Interventions ◽  
Detailed Medical History ◽  
Von Willebrand ◽  
Loop Electrosurgical Excision

Loop electrosurgical excision procedure (LEEP) is the first-line treatment for cervical intraepithelial neoplasia (CIN). It is effective, easy to perform and relatively safe for the patient. However, 1-2% of patients experience complications such as hemorrhage and infection, which usually are effectively treated using cauterization and antibiotics. We are presenting a case of repeated cervical and vaginal hemorrhage after the cervical LEEP for a patient without previous medical history of severe bleeding or detected bleeding disorders. A generally healthy 38-year-old female underwent planned LEEP of cervix because of CIN II-III. Procedure was successful. Afterwards she was admitted to the Emergency department several times because of recurrent vaginal and cervical bleeding. She received suturing and coagulation of the cervix and vaginal wall combined with desmopressin and tranexamic acid therapy. Because of suspected bleeding disorder hematologist was invited. Laboratory analysis showed positive results for von Willebrand disease. After VIII/von Willebran factor concentrate treatment bleeding was stopped completely. Before any surgical interventions it is important to take a detailed medical history. If atypical, recurrent and/or severe secondary hemorrhage after the surgical manipulations occur, coagulation disorders should be excluded.

scholarly journals A case of congenital esophagobronchial fistula which was diagnosed by detailed medical history taking

2011 ◽  
Vol 25 (5) ◽  
pp. 491-496
Author(s):  
Mitunobu Tamura ◽  
Hirokazu Nakajima ◽  
Hirochiyo Sawaguchi ◽  
Yasuharu Nagai ◽  
Takeshi Kawaguchi ◽  
...  
Keyword(s):  
Medical History ◽  
Medical History Taking ◽  
History Taking ◽  
Esophagobronchial Fistula ◽  
Detailed Medical History

scholarly journals Oral Adverse Reactions Caused by Over-the-Counter Oral Agents

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Vanja Vucicevic Boras ◽  
Vlaho Brailo ◽  
Ana Andabak Rogulj ◽  
Danica Vidovic Juras ◽  
Dragana Gabric ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Medical History ◽  
Adverse Reactions ◽  
Diagnostic Procedures ◽  
Topical Steroids ◽  
Over The Counter ◽  
Systemic Steroids ◽  
Oral Agents ◽  
Detailed Medical History ◽  
Proper Diagnosis

Over-the-counter products rarely cause unwanted reactions in the oral cavity. Oral reactions to these agents are not specific and might present with various clinical oral findings. Detailed medical history is a key to the proper diagnosis of these lesions and fortunately other diagnostic procedures are rarely needed. Lesions are usually managed with elimination of the offending agent and with topical steroids. In more severe cases systemic steroids should be applied.

scholarly journals A chaos-based medical image encryption method

2020 ◽  
Vol 19 (3) ◽  
pp. 1316
Author(s):  
Xuehong Wang ◽  
Chunling Tu
Keyword(s):  
Social Security ◽  
Health System ◽  
Medical History ◽  
Chaotic System ◽  
Medical Image ◽  
Chaotic Dynamics ◽  
Original Image ◽  
Detailed Medical History ◽  
Encryption Method ◽  
Differential Attacks

<span lang="EN-US">The information in the e-health system involves the patient’s privacy which is extremely sensitive. For instance, these information record social security numbers and detailed medical history.  When the breach happens, there are illegal, or disclosure behaviors taken to privacy that should be compromised security. In this paper, the medical digital images are protected by the proposed chaos-based encryption method in the process of transmission and utilization. Then the authentication is granted to patients and telemedicine staffs by the decryption method proposed. The Qi 3-D four wing chaotic system is employed in this method. The proposed method promises the keys with higher complexity and unpredictability than traditional cryptography methods by introducing the chaotic dynamics in the new cryptography. Digital medical images are used to validate the proposed method under the brute and the differential attacks. The pixels of the image are scrambled completely based on cat map and the sub-blocks of the image are diffused in the way that the original image is changed into a chaotic image robust to all kinds of attacks. The experiments show that the proposed method has higher performance and higher computation for decryption.</span>

Submasseteric abscess

2001 ◽  
Vol 115 (1) ◽  
pp. 68-70 ◽  
Author(s):  
Dimitrios G. Balatsouras ◽  
Georgios M. Kloutsos ◽  
Dionysis Protopapas ◽  
Stavros Korres ◽  
Constantinos Economou
Keyword(s):  
Computed Tomography ◽  
Young Adult ◽  
Medical History ◽  
Clinical Examination ◽  
Adult Male ◽  
Surgical Intervention ◽  
Accurate Diagnosis ◽  
Efficient Treatment ◽  
Young Adult Male ◽  
Detailed Medical History

The masseteric space is an important tissue compartment of the neck, but disease in it is difficult to diagnose and treat. In this paper a case of a young adult male with an abscess of the submasseteric space is presented. Diagnosis was established by computed tomography (CT) of the neck, but the severity of the lesion was not accurately estimated. Surgical intervention was performed and a large quantity of pus was drained. A detailed medical history and clinical examination of the patient as well as CT are important tools in the accurate diagnosis and efficient treatment of the disease.

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