Abstract P002: Heavy Alcohol Consumption Increases the Risk of Atrial Fibrillation -Circulatory Risk in Communities Study(CIRCS)

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Fumihiko Sano ◽  
Tetsuya Ohira ◽  
Akihiko Kitamura ◽  
Hironori Imano ◽  
Renzhe Cui ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Medical History ◽  
Moderate Alcohol Consumption ◽  
Heavy Alcohol ◽  
Ethanol Drinking ◽  
Wide Range ◽  
Detailed Medical History ◽  
Heavy Alcohol Consumption

Background— Evidence on the relationship of a wide range of alcohol consumption with risk of incident atrial fibrillation has been limited. Methods— Between 1991 and 1995, 8602 Japanese men and women aged 30 to 80 years and free of clinical atrial fibrillation took part in the first examination of the Circulatory Risk in Communities Study(CIRCS)- a population based cohort study of cardiovascular risk factors, cardiovascular disease incidence, and their trends in Japanese communities. In the first examination, we checked a detailed medical history, physical examination, blood and urine examination, and electrocardiogram (ECG). An interviewer obtained histories in detail for weekly alcohol intake. In the follow-up period, incident atrial fibrillations were ascertained by annual ECG record and medical history of treatment of atrial fibrillation. ECGs were coded with the Minnesota Code by trained physician-epidemiologists. Differences in baseline characteristics between atrial fibrillation cases and controls were compared using Student t-tests or chi-squared tests. The hazard ratios (HRs) of incidence of atrial fibrillation and 95% confidence interval (CI) relative to the never-drinking group were calculated with adjustment for age and other potential confounding factors using the Cox proportional hazard model. Results— During an average follow-up of 6.4 years, 290 incident atrial fibrillation occurred. The higher incidence rate of atrial fibrillation was observed among participants with more than 69 g of ethanol drinking per week, compared with less than 69 g of ethanol drinking per week. On the other hand, light to moderate alcohol consumption was not associated with risk of atrial fibrillation. Compared with the never drinking group, the multivariable-adjusted HRs of past, light (<23 g), light moderate (23-46 g), moderate (46-69 g), and heavy (>69 g) drinking groups were 1.20 (95% CI, 0.61-2.35), 0.85 (95% CI, 0.57-1.27), 1.05 (95% CI, 0.63-1.75), 1.34 (95% CI, 0.78-2.32), and 2.92 (95% CI, 1.61-5.28), respectively. Conclusions— Heavy alcohol consumption was associated with the higher risk of atrial fibrillation, whereas there was no association of less than moderate alcohol consumption and atrial fibrillation.

scholarly journals Heavy Alcohol Consumption and Risk of Atrial Fibrillation

2014 ◽  
Vol 78 (4) ◽  
pp. 955-961 ◽  
Author(s):  
Fumihiko Sano ◽  
Tetsuya Ohira ◽  
Akihiko Kitamura ◽  
Hironori Imano ◽  
Renzhe Cui ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Heavy Alcohol ◽  
Heavy Alcohol Consumption

scholarly journals Effect of alcohol consumption on the risk of adverse events in atrial fibrillation: from the COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF) registry

EP Europace ◽  
2020 ◽  
Author(s):  
Chewan Lim ◽  
Tae-Hoon Kim ◽  
Hee Tae Yu ◽  
So-Ryoung Lee ◽  
Myung-Jin Cha ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Adverse Events ◽  
Reference Group ◽  
Symptom Control ◽  
Adverse Outcomes ◽  
Heavy Alcohol ◽  
Hazard Ratios ◽  
Increased Risk ◽  
Heavy Alcohol Consumption

Abstract Aims The aim of this study is to determine the relationship between alcohol consumption and atrial fibrillation (AF)-related adverse events in the AF population. Methods and results A total of 9411 patients with nonvalvular AF in a prospective observational registry were categorized into four groups according to the amount of alcohol consumption—abstainer-rare, light (&lt;100 g/week), moderate (100–200 g/week), and heavy (≥200 g/week). Data on adverse events (ischaemic stroke, transient ischaemic attack, systemic embolic event, or AF hospitalization including for AF rate or rhythm control and heart failure management) were collected for 17.4 ± 7.3 months. A Cox proportional hazard models was performed to calculate hazard ratios (HRs), and propensity score matching was conducted to validate the results. The heavy alcohol consumption group showed an increased risk of composite adverse outcomes [adjusted hazard ratio (aHR) 1.32, 95% confidence interval (CI) 1.06–1.66] compared with the reference group (abstainer-rare group). However, no significant increased risk for adverse outcomes was observed in the light (aHR 0.88, 95% CI 0.68–1.13) and moderate (aHR 0.91, 95% CI 0.63–1.33) groups. In subgroup analyses, adverse effect of heavy alcohol consumption was significant, especially among patients with low CHA2DS2-VASc score, without hypertension, and in whom β-blocker were not prescribed. Conclusion Our findings suggest that heavy alcohol consumption increases the risk of adverse events in patients with AF, whereas light or moderate alcohol consumption does not.

scholarly journals Alcohol Abstinence and the Risk of Atrial Fibrillation in Patients With Newly Diagnosed Type 2 Diabetes Mellitus: A Nationwide Population-Based Study

2021 ◽  
Author(s):  
You-jung Choi ◽  
Kyung-Do Han ◽  
Eue-Keun Choi ◽  
Jin-Hyeung Jung ◽  
So-Ryoung Lee ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Newly Diagnosed ◽  
Heavy Alcohol ◽  
Alcohol Abstinence ◽  
Heavy Alcohol Consumption ◽  
New Onset

<b>Objectives:</b> To investigate the effects of alcohol abstinence in preventing new-onset atrial fibrillation (AF) in patients with type 2 diabetes mellitus (T2DM). <p><b>Research Design and Methods:</b> A total of 1,112,682 patients newly diagnosed with T2DM between 2011–2014, were identified from the Korean National Health Insurance Service database. After excluding a previous history of AF, 175,100 subjects were included. The primary outcome was new-onset AF.</p> <p><b>Results:</b> During a mean follow-up of 4.0 years, AF occurred in 4,174 patients. Heavy alcohol consumption (alcohol intake ≥40 g/day) before a T2DM diagnosis had a higher risk of AF (adjusted hazard ratio [aHR] 1.22, 95% confidence interval [CI] 1.06–1.41) compared to no alcohol consumption. After a T2DM diagnosis, moderate-to-heavy alcohol consumption (alcohol intake ≥20 g/day) who abstained from alcohol had a lower risk of AF (aHR 0.81, 95% CI 0.68–0.97) than did constant drinkers. Alcohol abstinence showed consistent trends toward lower incident AF in all subgroups and was statistically significant in men (aHR 0.80, 95% CI 0.67–0.96), those aged >65 years (aHR 0.69, 95% CI 0.52–0.91), those with CHA<sub>2</sub>DS<sub>2</sub>-VASc score <3 points (aHR 0.71, 95% CI 0.59–0.86), non-insulin users (aHR 0.77, 95% CI 0.63–0.94), and body mass index < 25 mg/k<sup>2</sup> (aHR 0.68, 95% CI 0.53–0.88).</p> <p><b>Conclusions</b>: In patients with newly diagnosed T2DM, alcohol abstinence was associated with a low risk of AF development. Lifestyle modifications, such as alcohol abstinence, in patients newly diagnosed with T2DM should be recommended to reduce the risk of AF.</p>

Abstract P237: Moderate and Heavy Alcohol Consumption Are Associated With Decreased Systolic Function After 8 Years of Follow-up

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Hanne Van Ballegooijen ◽  
Petra J Elders ◽  
Coen D Stehouwer ◽  
Jacqueline M Dekker ◽  
Joline Beulens
Keyword(s):  
Alcohol Consumption ◽  
Systolic Function ◽  
Heavy Drinking ◽  
Left Ventricular ◽  
Volume Index ◽  
Heavy Alcohol ◽  
Heavy Drinkers ◽  
Heavy Alcohol Consumption ◽  
Excessive Alcohol

Introduction: Excessive alcohol consumption is an important risk factors for cardiovascular disease, however, the underlying mechanisms are not well understood. Hypothesis: We assessed the hypothesis whether alcohol consumption is prospectively associated with unfavorable measures of cardiac structure and function. Methods: We used data from the Hoorn Study, a population-based, prospective cohort study. Data on self-reported alcohol consumption were collected with a validated food frequency questionnaire in 2000/2001(baseline for the current analyses). Echocardiography was performed in 2000/2001 in 582 participants and in 2007/2009 in 339 participants. Participants were classified into 5 categories based on self-reported alcohol consumption (glasses per week): 0 (non-drinkers), 0- 3 (light-drinkers), ≥3-7 (light to moderate drinkers), ≥7-14 (moderate drinkers) and ≥14 (heavy drinkers). Light drinking was considered the reference group. We studied the association of alcohol consumption with echocardiographic measures after 8 years of follow-up using linear regression analyses, adjusting for potential confounders. Results: The mean age was 69.8±6.5 years and 50% was female. After 7.4±0.5 years follow-up, moderate and heavy alcohol consumption were associated with a decreased left ventricular ejection fraction of -5.1% (-8.7, -1.4) for moderate and -4.8% (-8.8, -0.8) for heavy drinkers (Table). Heavy drinking was also associated with a decrease in left atrial volume index: -3.9mL/m 2 (-7.6, -0.2). No longitudinal associations were found between alcohol consumption and left ventricular mass index. Conclusion: Both moderate and heavy drinking were associated with decreased systolic function after 8 years follow-up. The toxic effect of alcohol could lead to underfilling of the left atrium which could lead to lower systolic function. These findings may explain the increased cardiovascular risk among people with excessive alcohol use.

scholarly journals A Dose-Response Meta-Analysis on the Association Between Alcohol Consumption and Incidence of Atrial Fibrillation

2020 ◽  
Author(s):  
Haifu Zhang ◽  
Qinxia Zhang ◽  
Dong Yang ◽  
Zhao Xu ◽  
Xingwei Zhang
Keyword(s):  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Dose Response ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Response Curves ◽  
Female Population ◽  
Men And Women ◽  
Heavy Alcohol ◽  
Heavy Alcohol Consumption

Abstract Background: Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice. Alcohol consumption has been linked to the occurrence of AF.Methods: A comprehensive search of electronic databases (PubMed, Cochrane Library, OVID, Google scholar, and Web of Science) was performed. The search yielded a total of 1177 articles, and 12 cohort studies from the total were included in the meta-analysis. The effects of different doses of alcohol consumption on the risk of AF in men and women were compared using hierarchical analysis. Dose-response curves of alcohol consumption and risk of AF were plotted for the two groups according to sex.Results: The risk of AF increased with increased alcohol consumption in both men and women. In the male population, light-moderate alcohol consumption did not increase the risk of AF (HR: 1.07, 95%CI: 0.92-1.23, P=0.38), while heavy alcohol consumption significantly increased the risk of AF (HR: 1.38, 95%CI: 1.23-1.54, P<0.01). In the female population, the risk of AF was not significantly increased by either light-moderate or heavy alcohol consumption (light- moderate drink: HR: 1.00, 95%CI: 0.92-1.10, P=0.95; heavy drink: HR: 1.05, 95%CI: 0.90-1.23, P=0.55).Conclusions: In women, the risk of AF was not associated with any degree of alcohol consumption while high levels of alcohol consumption significantly increased the risk of AF in men.

scholarly journals Follow-Up Data Improve the Estimation of the Prevalence of Heavy Alcohol Consumption

2018 ◽  
Vol 53 (5) ◽  
pp. 586-596 ◽  
Author(s):  
Juho Kopra ◽  
Pia Mäkelä ◽  
Hanna Tolonen ◽  
Pekka Jousilahti ◽  
Juha Karvanen
Keyword(s):  
Alcohol Consumption ◽  
Heavy Alcohol ◽  
Heavy Alcohol Consumption

scholarly journals Alcohol Abstinence and the Risk of Atrial Fibrillation in Patients With Newly Diagnosed Type 2 Diabetes Mellitus: A Nationwide Population-Based Study

2021 ◽  
Author(s):  
You-jung Choi ◽  
Kyung-Do Han ◽  
Eue-Keun Choi ◽  
Jin-Hyeung Jung ◽  
So-Ryoung Lee ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Newly Diagnosed ◽  
Heavy Alcohol ◽  
Alcohol Abstinence ◽  
Heavy Alcohol Consumption ◽  
New Onset

<b>Objectives:</b> To investigate the effects of alcohol abstinence in preventing new-onset atrial fibrillation (AF) in patients with type 2 diabetes mellitus (T2DM). <p><b>Research Design and Methods:</b> A total of 1,112,682 patients newly diagnosed with T2DM between 2011–2014, were identified from the Korean National Health Insurance Service database. After excluding a previous history of AF, 175,100 subjects were included. The primary outcome was new-onset AF.</p> <p><b>Results:</b> During a mean follow-up of 4.0 years, AF occurred in 4,174 patients. Heavy alcohol consumption (alcohol intake ≥40 g/day) before a T2DM diagnosis had a higher risk of AF (adjusted hazard ratio [aHR] 1.22, 95% confidence interval [CI] 1.06–1.41) compared to no alcohol consumption. After a T2DM diagnosis, moderate-to-heavy alcohol consumption (alcohol intake ≥20 g/day) who abstained from alcohol had a lower risk of AF (aHR 0.81, 95% CI 0.68–0.97) than did constant drinkers. Alcohol abstinence showed consistent trends toward lower incident AF in all subgroups and was statistically significant in men (aHR 0.80, 95% CI 0.67–0.96), those aged >65 years (aHR 0.69, 95% CI 0.52–0.91), those with CHA<sub>2</sub>DS<sub>2</sub>-VASc score <3 points (aHR 0.71, 95% CI 0.59–0.86), non-insulin users (aHR 0.77, 95% CI 0.63–0.94), and body mass index < 25 mg/k<sup>2</sup> (aHR 0.68, 95% CI 0.53–0.88).</p> <p><b>Conclusions</b>: In patients with newly diagnosed T2DM, alcohol abstinence was associated with a low risk of AF development. Lifestyle modifications, such as alcohol abstinence, in patients newly diagnosed with T2DM should be recommended to reduce the risk of AF.</p>

scholarly journals Genetically determined tobacco and alcohol use and risk of atrial fibrillation

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Yunlong Lu ◽  
Yan Guo ◽  
Hefeng Lin ◽  
Zhen Wang ◽  
Liangrong Zheng
Keyword(s):  
Atrial Fibrillation ◽  
Smoking Cessation ◽  
Alcohol Consumption ◽  
Alcohol Use ◽  
Smoking Initiation ◽  
Genome Wide Association Studies ◽  
Heavy Alcohol ◽  
A Genome ◽  
Heavy Alcohol Consumption ◽  
Mr Study

Abstract Background The causality between the use of alcohol and cigarettes and atrial fibrillation (AF) remains controversial. We conducted a Mendelian randomization (MR) study to evaluate the association of genetic variants related to tobacco and alcohol use with AF. Methods Single nucleotide polymorphisms (SNPs) related to smoking initiation (N = 374), age at initiation of regular smoking (N = 10), cigarettes per day (N = 55), and smoking cessation (N = 24) were derived from a genome-wide association studies (GWAS) of tobacco use (N = 1.2 million individuals). SNPs related to heavy alcohol use (N = 6) were derived from a GWAS of UK biobank (N = 125,249 individuals). The genetically matching instrumented variables were obtained from the GWAS of AF (N = 588,190 individuals). The estimates between tobacco and alcohol use and AF were combined by inverse-variance weighted (IVW), simple median, weighted median, MR-robust adjusted profile score method, MR-PRESSO, and multivariable MR. Results A total of 65,446 AF patients and 522,744 referents were included. In the IVW analysis, the odds ratio per one-unit increase of smoking initiation was 1.11 (95% CI, 1.06–1.16; P = 3.35 × 10−6) for AF. Genetically predicted age at initiation of regular smoking, cigarettes per day and smoking cessation were not associated with AF. The IVW estimate showed that heavy alcohol consumption increased AF risk (OR, 1.11; 95% CI, 1.04–1.18; P = 0.001). The results were consistent in complementary analyses and multivariable MR. Conclusion Our MR study indicated that regular smoking was associated with increased risk of AF, no matter the age at initiation of regular smoking, or the number of cigarettes smoked per day. Genetically predicted heavy alcohol consumption increased the risk of AF.

scholarly journals Prospective Associations Between Alcohol Consumption and Psychological Well-being in Midlife

2021 ◽  
Author(s):  
Marie Grønkjær ◽  
Cathrine Lawaetz Wimmelmann ◽  
Erik Lykke Mortensen ◽  
Trine Flensborg-Madsen
Keyword(s):  
Alcohol Consumption ◽  
Binge Drinking ◽  
Satisfaction With Life ◽  
Well Being ◽  
Psychological Well Being ◽  
Men And Women ◽  
Heavy Alcohol ◽  
Alcohol Abstinence ◽  
Heavy Alcohol Consumption

Abstract Background: Alcohol consumption potentially influences psychological well-being in beneficial and harmful ways, but prospective studies on the association show mixed results. Our main purpose was to examine prospective associations between alcohol consumption and psychological well-being in middle-aged men and women. Methods: The study sample included 4,148 middle-aged individuals (80% men) from the Copenhagen Aging and Midlife Biobank who reported their alcohol consumption (average weekly consumption and frequency of binge drinking) at baseline in 2004 or 2006 and reported their psychological well-being (satisfaction with life and vitality) at follow-up in 2009–2011. Analyses were adjusted for sociodemographic factors, lifestyle, social relations, and morbidity.Results: For satisfaction with life at follow-up, lower scores were observed in men and women who were alcohol abstinent at baseline as well as in men with heavy alcohol consumption compared with moderate alcohol consumption at baseline. Moreover, men with moderate frequency of binge drinking (1–3 times/month) at baseline had higher satisfaction with life scores at follow-up than men with less and more frequent binge drinking. In relation to vitality at follow-up, alcohol abstinence at baseline in men and women and heavy alcohol consumption at baseline in men were associated with lower scores compared with moderate alcohol consumption. Conclusions: Alcohol abstinence seems to be prospectively associated with adverse psychological well-being in men and women, while heavy alcohol consumption seems to be prospectively associated with adverse psychological well-being in men. Finally, an inverse u-shaped prospective association between binge drinking and life satisfaction was observed in men.

scholarly journals Alcohol use and risk of intracerebral hemorrhage

Neurology ◽  
2017 ◽  
Vol 88 (21) ◽  
pp. 2043-2051 ◽  
Author(s):  
Ching-Jen Chen ◽  
W. Mark Brown ◽  
Charles J. Moomaw ◽  
Carl D. Langefeld ◽  
Jennifer Osborne ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Intracerebral Hemorrhage ◽  
Reference Group ◽  
Strong Association ◽  
Moderate Alcohol Consumption ◽  
Protective Effects ◽  
Heavy Alcohol ◽  
Heavy Alcohol Consumption ◽  
Race Ethnicity

Objective:To analyze the dose–risk relationship for alcohol consumption and intracerebral hemorrhage (ICH) in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study.Methods:ERICH is a multicenter, prospective, case-control study, designed to recruit 1,000 non-Hispanic white patients, 1,000 non-Hispanic black patients, and 1,000 Hispanic patients with ICH. Cases were matched 1:1 to ICH-free controls by age, sex, race/ethnicity, and geographic area. Comprehensive interviews included questions regarding alcohol consumption. Patterns of alcohol consumption were categorized as none, rare (<1 drink per month), moderate (≥1 drink per month and ≤2 drinks per day), intermediate (>2 drinks per day and <5 drinks per day), and heavy (≥5 drinks per day). ICH risk was calculated using the no-alcohol use category as the reference group.Results:Multivariable analyses demonstrated an ordinal trend for alcohol consumption: rare (odds ratio [OR] 0.57, p < 0.0001), moderate (OR 0.65, p < 0.0001), intermediate (OR 0.82, p = 0.2666), and heavy alcohol consumption (OR 1.77, p = 0.0003). Subgroup analyses demonstrated an association of rare and moderate alcohol consumption with decreased risk of both lobar and nonlobar ICH. Heavy alcohol consumption demonstrated a strong association with increased nonlobar ICH risk (OR 2.04, p = 0.0003). Heavy alcohol consumption was associated with significant increase in nonlobar ICH risk in black (OR 2.34, p = 0.0140) and Hispanic participants (OR 12.32, p < 0.0001). A similar association was not found in white participants.Conclusions:This study demonstrated potential protective effects of rare and moderate alcohol consumption on ICH risk. Heavy alcohol consumption was associated with increased ICH risk. Race/ethnicity was a significant factor in alcohol-associated ICH risk; heavy alcohol consumption in black and Hispanic participants poses significant nonlobar ICH risk.

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