Predictive role of endometrial T-bet/GATA3 ratio during mid-luteal phase for live birth in patients undergoing in vitro fertilization: A retrospective observational study

2021 ◽  
pp. 103465
Author(s):  
Yuye Li ◽  
Shuyi Yu ◽  
Chunyu Huang ◽  
Lianghui Diao ◽  
Cong Chen ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Observational Study ◽  
Live Birth ◽  
Luteal Phase ◽  
Retrospective Observational Study ◽  
Vitro Fertilization ◽  
Predictive Role

scholarly journals The Role of Advanced Age and Duration of Infertility on Oocyte Number Retrieved during In Vitro Fertilization

Jurnal NERS ◽  
2016 ◽  
Vol 9 (2) ◽  
pp. 183
Author(s):  
Hendy Hendarto
Keyword(s):  
In Vitro Fertilization ◽  
Observational Study ◽  
Gnrh Antagonist ◽  
Fertilization Program ◽  
Vitro Fertilization ◽  
Infertile Women ◽  
Definitive Therapy ◽  
Fertility Clinic

Introduction: The number of oocytes retrieved during in vitro fertilization related to the success of pregnancy. Today in vitro fertilization has been considered as definitive therapy for infertility problem. Age and duration of infertility is an important factor in infertility that should be evaluated in detail. The purpose of this study was to clarify the role of age and duration of infertility on the number of oocytes retrieved during in vitro fertilization. Method: This was an analytic observational study, including infertile female patients who followed the in vitro fertilization program at Fertility Clinic Graha Amarta Dr Soetomo Hospital Surabaya. Total sampling was conducted during January 1st-June 30th 2014 and found 66 study subjects. Evaluation was performed on age, duration of infertility and the number of oocytes retrieved following ovarian stimulation using FSH and GnRH antagonist injection. All data were analyzed by ANOVA test with level significance of ≤ 0.05. Result: In the group of age <35 years the average number of oocytes retrieved was 9.43 ± 6.29 oocytes, and in the group of age ≥ 35 years averaged number was 6.03 ± 4.67 oocytes. There was significant differences of oocytes number retrieved between the two groups (p = 0.017). The number of oocytes retrieved in group of duration of infertility 1-2 years, 3-4 years and ≥ 5 years were 13.40 ± 3.28 ; 8.64 ± 6.80 and 6.82 ± 5.45, respectively. There was significant differences of oocytes number retrieved between the three groups of duration of infertility (p = 0.017). Discussion:. The advanced of age and the longer duration of infertility may contribute to the incidence of the less number of oocytes retrieved in infertile women who follow in vitro fertilization.Keywords: age, duration of infertility, oocyte, in vitro fertilization

scholarly journals Double or dual stimulation in poor ovarian responders: where do we stand?

2021 ◽  
Vol 15 ◽  
pp. 263349412110241
Author(s):  
Mehtap Polat ◽  
Sezcan Mumusoglu ◽  
Irem Yarali Ozbek ◽  
Gurkan Bozdag ◽  
Hakan Yarali
Keyword(s):  
Menstrual Cycle ◽  
In Vitro Fertilization ◽  
Live Birth ◽  
Ovarian Stimulation ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Vitro Fertilization ◽  
Poor Ovarian Responders ◽  
Double Stimulation

Recent advances in our recognition of two to three follicular waves of development in a single menstrual cycle has challenged the dogmatic approach of ovarian stimulation for in vitro fertilization starting in the early follicular phase. First shown in veterinary medicine and thereafter in women, luteal phase stimulation–derived oocytes are at least as competent as those retrieved following follicular phase stimulation. Poor ovarian responders still remain a challenge for many decades simply because they do not respond to ovarian stimulation. Performing follicular phase stimulation and luteal phase stimulation in the same menstrual cycle, named as double stimulation/dual stimulation, clearly increases the number of oocytes, which is a robust surrogate marker of live birth rate in in vitro fertilization across all female ages. Of interest, apart from one study, the bulk of evidence reports significantly higher number of oocytes following luteal phase stimulation when compared with follicular phase stimulation; hence, performing double stimulation/dual stimulation doubles the number of oocytes leading to a marked decrease in patient drop-out rate which is one of the major factors limiting cumulative live birth rates in such poor prognosis patients. The limited data with double stimulation/dual stimulation-derived embryos is reassuring for obstetric and neonatal outcome. The mandatory requirement of freeze-all and lack of cost-effectiveness data are limitations of this novel approach. Double stimulation/dual stimulation is an effective strategy when the need to obtain oocytes is urgent, including patients with malignant diseases undergoing oocyte cryopreservation and patients of advanced maternal age or with reduced ovarian reserve.

scholarly journals Association between endometrial indoleamine 2,3-dioxygenase expression level and pregnancy outcomes in women undergoing first in vitro fertilization treatment

2020 ◽  
Author(s):  
Su Liu ◽  
Hongxia Wei ◽  
Yuye Li ◽  
Ruochun Lian ◽  
Xiaohui Wang ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Pregnancy Outcomes ◽  
Luteal Phase ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Expression Level ◽  
Vitro Fertilization ◽  
Expression Levels

Abstract BackgroundIndoleamine 2,3-dioxygenase (IDO) has been reported to play a key role in placental development during normal pregnancy. However, the question of whether endometrial IDO expression affects in vitro fertilization (IVF) pregnancy outcomes remains unclear. The current study was undertaken to investigate whether there was any association between endometrial IDO expression and IVF treatment outcome.MethodsThis retrospective study was designed to compare pregnancy outcomes among women with different endometrial IDO expression levels under their first IVF treatment. A total of 140 women undergoing their IVF treatment were selected from January 2017 to December 2017. Endometrial samples were collected during mid-luteal phase before IVF cycle. The endometrial IDO expression levels were analyzed by immunohistochemistry, and compared between women who were pregnant or not. A logistic regression analysis was performed to determine the impact of endometrial IDO expression on live birth.ResultsNo significant differences in the endometrial IDO expression levels were found between women who had clinical pregnancy and those who failed (P>0.05). However, the endometrial IDO expression level was significantly higher among women who had live birth compared with those who had no live birth (P=0.031). Additionally, after adjusting for differences in maternal age, BMI and duration of gonadotropin stimulation, women with higher IDO expression level had an increased live birth rate (adjusted odds ratio [aOR] 2.863, 95% confidence interval [CI] 1.180-6.947). ConclusionsHigher endometrial IDO expression level during mid-luteal phase is associated with an increased live birth rate in women undergoing their first IVF treatment.

scholarly journals Association between endometrial indoleamine 2,3-dioxygenase expression level and pregnancy outcomes in women undergoing first in vitro fertilization treatment

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Su Liu ◽  
Ling Hong ◽  
Yuye Li ◽  
Ruochun Lian ◽  
Xiaohui Wang ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Pregnancy Outcomes ◽  
Luteal Phase ◽  
Immunohistochemical Staining ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Expression Level ◽  
Vitro Fertilization

Abstract Background Indoleamine 2,3-dioxygenase (IDO) has been reported to play a key role in placental development during normal pregnancy. However, the question of whether endometrial IDO expression affects in vitro fertilization (IVF) pregnancy outcomes remains unclear. The current study was undertaken to investigate whether there was any association between endometrial IDO immunohistochemical staining and IVF treatment outcome. Methods This retrospective study was designed to compare pregnancy outcomes among women with different endometrial IDO expression levels under their first IVF treatment. A total of 140 women undergoing their IVF treatment were selected from January 2017 to December 2017. Endometrial samples were collected during mid-luteal phase before IVF cycle. The endometrial IDO expression levels were analyzed by immunohistochemistry, and compared between women who were pregnant or not. A logistic regression analysis was performed to determine the impact of endometrial IDO staining on live birth. Results No significant differences in the endometrial IDO immunohistochemical staining were found between women who had clinical pregnancy and those who failed (P>0.05). However, the endometrial IDO staining was significantly higher among women who had live birth compared with those who had no live birth (P=0.031). Additionally, after adjusting for differences in maternal age, BMI and duration of gonadotropin stimulation, women with higher IDO expression level had an increased live birth rate (adjusted odds ratio [aOR] 2.863, 95% confidence interval [CI] 1.180-6.947). Conclusions Higher endometrial IDO expression level during mid-luteal phase is associated with an increased live birth rate in women undergoing their first IVF treatment.

Predictive Model for Live Birth at 12 Months After Starting In-Vitro Fertilization Treatment

MedPharmRes ◽  
2018 ◽  
Vol 2 (2) ◽  
pp. 5-20
Author(s):  
Vu Ho ◽  
Toan Pham ◽  
Tuong Ho ◽  
Lan Vuong
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Cox Regression ◽  
Financial Burden ◽  
Oocyte Retrieval ◽  
Operating Characteristics ◽  
Vitro Fertilization ◽  
Cox Regression Analysis ◽  
Significant Difference

IVF carries a considerable physical, emotional and financial burden. Therefore, it would be useful to be able to predict the likelihood of success for each couple. The aim of this retrospective cohort study was to develop a prediction model to estimate the probability of a live birth at 12 months after one completed IVF cycle (all fresh and frozen embryo transfers from the same oocyte retrieval). We analyzed data collected from 2600 women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) at a single center in Vietnam between April 2014 and December 2015. All patients received gonadotropin-releasing hormone (GnRH) antagonist stimulation, followed by fresh and/or frozen embryo transfer (FET) on Day 3. Using Cox regression analysis, five predictive factors were identified: female age, total dose of recombinant follicle stimulating hormone used, type of trigger, fresh or FET during the first transfer, and number of subsequent FET after the first transfer. The area under the receiver operating characteristics curve for the final model was 0.63 (95% confidence interval [CI] 0.60‒0.65) and 0.60 (95% CI 0.57‒0.63) for the validation cohort. There was no significant difference between the predicted and observed probabilities of live birth (Hosmer-Lemeshow test, p > 0.05). The model developed had similar discrimination to existing models and could be implemented in clinical practice.

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