Dose response relationship between exercise intensity and C Reactive Protein in sedentary individuals

2013 ◽  
Vol 16 ◽  
pp. e30 ◽  
Author(s):  
F. Davis ◽  
S. Vidyasagar ◽  
A. Maiya ◽  
A. Kamath
Keyword(s):  
Dose Response ◽  
Exercise Intensity ◽  
Response Relationship ◽  
C Reactive Protein ◽  
Dose Response Relationship ◽  
Reactive Protein

scholarly journals Exploring the Dose-Response Relationship between Resistance Exercise Intensity and Cognitive Function

2009 ◽  
Vol 31 (5) ◽  
pp. 640-656 ◽  
Author(s):  
Yu-Kai Chang ◽  
Jennifer L. Etnier
Keyword(s):  
Executive Function ◽  
Resistance Exercise ◽  
Cognitive Performance ◽  
Dose Response ◽  
Exercise Intensity ◽  
Perceived Exertion ◽  
Moderate Intensity ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Moderate Intensity Exercise

The purpose of this study was to explore the dose-response relationship between resistance exercise intensity and cognitive performance. Sixty-eight participants were randomly assigned into control, 40%, 70%, or 100% of 10-repetition maximal resistance exercise groups. Participants were tested on Day 1 (baseline) and on Day 2 (measures were taken relative to performance of the treatment). Heart rate, ratings of perceived exertion, self-reported arousal, and affect were assessed on both days. Cognitive performance was assessed on Day 1 and before and following treatment on Day 2. Results from regression analyses indicated that there is a significant linear effect of exercise intensity on information processing speed, and a significant quadratic trend for exercise intensity on executive function. Thus, there is a dose-response relationship between the intensity of resistance exercise and cognitive performance such that high-intensity exercise benefits speed of processing, but moderate intensity exercise is most beneficial for executive function.

Abstract MP034: Adiponectin Concentrations are Inversely Associated with Risk of Peripheral Arterial Disease in Men

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Michel M Joosten ◽  
Kaumudi J Joshipura ◽  
Jennifer K Pai ◽  
Monica L Bertoia ◽  
Eric B Rimm ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Arterial Disease ◽  
Response Relationship ◽  
C Reactive Protein ◽  
Dose Response Relationship ◽  
Blood Draw ◽  
Reactive Protein ◽  
Total Adiponectin ◽  
Peripheral Arterial

Background: Lower concentrations of adiponectin have been linked to the development of occlusive coronary events in otherwise healthy individuals. Whether similar relationships exist for the development of systemic atherosclerosis, such as peripheral arterial disease (PAD), is unknown. Methods: We used data from a prospective, nested case-control study among 18,225 male participants of the Health Professionals Follow-up Study aged 40 to 75 years who were free of diagnosed cardiovascular disease at the time of blood draw (1993–1995). During 14 years of follow-up through January 31, 2008, 143 men developed PAD. Using risk set sampling, controls were selected in a 3:1 ratio matched for age, date of blood draw, fasting status and smoking status (n=429). We used conditional logistic regression models to assess PAD risk. Results: Higher adiponectin concentrations were associated with a lower risk of PAD (Odds ratio [OR] per SD increase 0.58; 95% confidence interval [CI], 0.45–0.75) after controlling for pack-years of smoking, type 2 diabetes, hypertension, family history of myocardial infarction, aspirin use, body mass index and physical activity. Additional adjustment for low- and high-density lipoprotein cholesterol and high-sensitivity C-reactive protein concentrations attenuated the association (OR per SD increase, 0.71; 95% CI, 0.54–0.95). Further adjustment for hemoglobin A 1c , triglyceride, and gamma-glutamyltransferase concentrations did not alter the results. A log-linear inverse dose-response relationship was evident over the full spectrum of total adiponectin concentrations ( P trend =0.02; Figure). Conclusion: Total adiponectin concentrations are inversely associated with risk of PAD in otherwise healthy men. This relationship can only partly be explained by cholesterol and C-reactive protein concentrations and is independent of triglycerides and glycemic status. Figure legend: Dose-Response Relationship between Total Adiponectin Concentrations and Odds Ratio of PAD.

A SUBCUTANEOUS INJECTION ASSAY FOR ANTI-ANDROGENS IN THE CHICK

1962 ◽  
Vol 41 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Ralph I. Dorfman
Keyword(s):  
Dose Response ◽  
Subcutaneous Injection ◽  
Response Relationship ◽  
Dose Response Relationship

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.

Mathematical Interpretation of the Pharmacodynamics of Homoeopathic Medicines

2021 ◽  
Vol 34 (01) ◽  
pp. 003-016
Author(s):  
John Michel Warner
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Dose Response ◽  
Oral Route ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Force Line ◽  
Administration Routes ◽  
Medicinal Substances ◽  
Medicine Administration

AbstractAccording to Hahnemann, homoeopathic medicines must be great immune responses inducers. In crude states, these medicines pose severe threats to the immune system. So, the immune-system of an organism backfires against the molecules of the medicinal substances. The complex immune response mechanism activated by the medicinal molecules can handle any threats which are similar to the threats posed by the medicinal molecules. The intersectional operation of the two sets, medicine-induced immune responses and immune responses necessary to cure diseases, shows that any effective homoeopathic medicine, which is effective against any disease, can induce immune responses which are necessary to cure the specific disease. In this article, this mechanism has been exemplified by the action of Silicea in human body. Also, a neuroimmunological assessment of the route of medicine administration shows that the oral cavity and the nasal cavity are two administration-routes where the smallest doses (sometimes even few molecules) of a particular homoeopathic medicine induce the most effective and sufficient (in amount) purgatory immune responses. Administering the smallest unitary doses of Silicea in the oral route can make significant changes in the vital force line on the dose–response relationship graph. The dose–response relationship graph further implicates that the most effective dose of a medicine must be below the lethality threshold. If multiple doses of any medicine are administered at same intervals, the immune-system primarily engages with the medicinal molecules; but along the passage of time, the engagement line splits into two: one engages with the medicinal molecules and another engages with diseases. The immune system's engagement with the diseases increases along the passage of time, though the engagement with the medicinal molecules gradually falls with the administration of descending doses. Necessarily, I have shown through mathematical logic that the descending doses, though they seem to be funny, can effectively induce the most effective immune responses.

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