Further terpenoids from Vitex negundo L. growing in Vietnam

Background: Vitex negundo Linn. commonly known as five leave chase tree is an ethnobotanically important drug in traditional system of medicine. The plant is widely distributed in India, China and other Asian and American countries. Objective: The review aims at presenting comprehensive information with respect to ethnopharmacological rele-vance and recent findings on phytochemical and biological activities of Vitex negundo. Method: Literature was collected from various sources such as pubmed, scopus, science direct, and others. Results: Extracts and secondary metabolites of this plant, particularly those from roots and leaves, possess useful pharmacological activities such as anti-inflammatory, antitumor, antioxidant, antimicrobial, galactagogue, antigas-tric, antiflatulant, antiparasitic, analgesic, hepatoprotective and antihypertensive, some of which have been vali-dated scientifically. All parts of plant especially leave and roots contain a large number of bioactive phytoconstitu-ents including flavonoids, iridoids, lignans, volatile oil, terpenes, coumarins, phenolic and steroidal compounds which impart it multiple medicinal properties. Vitexin, isovitexin, viridifol, caffeic acid, chlorogenic acid and iso-chlorogenic acid are the main components. Conclusion: The review emphasises the medicinal importance of Vitex negundo and its bioactive constituents in traditional system of medicine.

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Molecular docking and simulation studies of natural compounds of Vitex negundo L. against papain-like protease (PLpro) of SARS CoV-2 (coronavirus) to conquer the pandemic situation in the world

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2021.1873185 ◽

2021 ◽

pp. 1-22

Author(s):

Debasis Mitra ◽

Devvret Verma ◽

Bhaswatimayee Mahakur ◽

Anshul Kamboj ◽

Rakesh Srivastava ◽

...

Keyword(s):

Molecular Docking ◽

Natural Compounds ◽

Vitex Negundo ◽

Simulation Studies ◽

The World

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Micro-Structural Stability of Micropropagated Plants of Vitex negundo L.

Microscopy and Microanalysis ◽

10.1017/s1431927621000283 ◽

2021 ◽

pp. 1-9

Author(s):

M. Manokari ◽

S. Priyadharshini ◽

Mahipal S. Shekhawat

Keyword(s):

Structural Changes ◽

Growth Conditions ◽

Culture Industry ◽

Vascular Bundles ◽

Vitex Negundo ◽

Structural Variations ◽

Structural Repair ◽

Micropropagated Plants ◽

Palisade Cells

Abstract Micropropagation techniques allow producing large numbers of clones of genetically identical plants. However, there is evidence of disorders in internal structures due to sophisticated in vitro conditions. Such variations are responsible for the mortality of plantlets in the field and cause huge loss to the tissue culture industry. Anatomical evaluation at different growth conditions allows for understanding structural repair of in vitro raised plantlets. Therefore, the present study was aimed to identify the structural changes that occurred in micropropagated plants of Vitex negundo under heterotrophic, photomixotrophic, and photoautotrophic conditions. To achieve this, structural variations were analyzed in the plantlets obtained from in vitro, greenhouse and field transferred stages using light microscopy. Underdeveloped dermal tissues, palisade cells, intercellular spaces, mechanical tissues, vascular bundles, and ground tissues were observed with the plants growing under in vitro conditions. The self-repairing of structural disorders and transitions in vegetative anatomy was observed during hardening under the greenhouse environment. Field transferred plantlets were characterized by well-developed internal anatomy. These findings showed that the micropropagated plantlets of V. negundo were well-adapted through a series of self-repairing the in vitro induced structural abnormalities at the subsequent stages of plant development.

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