scholarly journals Transfer of drug dissolution testing by statistical approaches: Case study

2012 ◽  
Vol 20 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Mohammed Amood AL-Kamarany ◽  
Miloud EL Karbane ◽  
Khadija Ridouan ◽  
Fars K. Alanazi ◽  
Philippe Hubert ◽  
...  
Keyword(s):  
Drug Dissolution ◽  
Dissolution Testing ◽  
Statistical Approaches

scholarly journals Automatic Dissolution Testing with High-Temporal Resolution for Both Immediate-Release and Fixed-Combination Drug Tablets

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Zhongmei Chi ◽  
Irfan Azhar ◽  
Habib Khan ◽  
Li Yang ◽  
Yunxiang Feng
Keyword(s):  
High Speed ◽  
Sequential Analysis ◽  
Immediate Release ◽  
Drug Dissolution ◽  
High Temporal Resolution ◽  
Dissolution Profile ◽  
Dissolution Testing ◽  
Combination Drug ◽  
Efficient Separation ◽  
High Efficient

AbstractDissolution testing plays many important roles throughout the pharmaceutical industry, from the research and development of drug products to the control and evaluation of drug quality. However, it is a challenging task to perform both high-efficient separation and high-temporal detection to achieve accurate dissolution profile of each active ingredient dissolved from a drug tablet. In our study, we report a novel non-manual-operation method for performing the automatic dissolution testing of drug tablets, by combining a program-controlled sequential analysis and high-speed capillary electrophoresis for efficient separation of active ingredients. The feasibility of the method for dissolution testing of real drug tablets as well as the performance of the proposed system has been demonstrated. The accuracy of drug dissolution testing is ensured by the excellent repeatability of the sequential analysis, as well as the similarity of the evaluation of dissolution testing. Our study show that the proposed method is capable to achieve simultaneous dissolution testing of multiple ingredients, and the matrix interferences can be avoided. Therefore it is of potential valuable applications in various fields of pharmaceutical research and drug regulation.

scholarly journals The Connection between Education and Religious Insight with Madrasah Teachers’ Work Motivation in Indonesia

2016 ◽  
Vol 6 (2) ◽  
pp. 251
Author(s):  
Anis Fauzi ◽  
Eni Nur’aeni
Keyword(s):  
Data Analysis ◽  
Work Motivation ◽  
Case Study Approach ◽  
Study Approach ◽  
Quantitative Data Analysis ◽  
Statistical Approaches ◽  
The Relationship ◽  
Regression Correlation ◽  
Descriptive Method

This study aimed to determine the reality of education and religious insight of madrasah teachers as well as the relationship between education and religious insights with madrasah teachers’ work motivation in Serang District, Banten Province. The method used is descriptive method with case study approach and quantitative data analysis. The research sites were at Sultan Agung Madrasah Tirtayasa, Nurul Huda Madrasah Baros and Raudhatul Ulum Madrasah Anyer. The respondents were 50 councilors in each madrasah. Data collection techniques used in the study were questionnaires, observations, and interviews. Based on the data analysis using statistical approaches and the development of a linear regression formula and multiple regression, correlation values are quite high among the variables of educational insights (X1) with the variables of madrasah teachers’ work motivation (Y); and between variables of religious insight (X2) with the madrasah teachers’ work motivation (Y); as well as between the variables of religious and education insight (X1 and X2) with the variables of madrasah teachers’ work motivation (Y).

Water Level Short-Term Forecasting Using Statistical Approaches: A Case Study on the Parisian Region

2020 ◽  
pp. 453-463
Author(s):  
Nicolas Cheifetz ◽  
Hugo Senetaire ◽  
Cédric Féliers ◽  
Véronique Heim
Keyword(s):  
Water Level ◽  
Short Term ◽  
Statistical Approaches ◽  
Short Term Forecasting

scholarly journals Impact of Food and Drink Administration Vehicles on Paediatric Formulation Performance Part 2: Dissolution of Montelukast Sodium and Mesalazine Formulations

2020 ◽  
Vol 21 (7) ◽  
Author(s):  
J. Martir ◽  
T. Flanagan ◽  
J. Mann ◽  
Nikoletta Fotaki
Keyword(s):  
Drug Formulation ◽  
Drug Dissolution ◽  
Simulated Gastric Fluid ◽  
Dissolution Testing ◽  
Drug Bioavailability ◽  
Age Appropriate ◽  
Direct Administration ◽  
The Impact ◽  
Paediatric Formulation

Abstract Paediatric medicines are not always age-appropriate, causing problems with dosing, acceptability and adherence. The use of food and drinks as vehicles for medicine co-administration is common practice, yet the impact on drug bioavailability, safety and efficacy remains unaddressed. The aim of this study was to use in vitro dissolution testing, under infant simulating conditions, to evaluate the effect of co-administration with vehicles on the dissolution performance of two poorly soluble paediatric drugs. Dissolution studies of mesalazine and montelukast formulations were conducted with mini-paddle apparatus on a two-stage approach: simulated gastric fluid followed by addition of simulated intestinal fluid. The testing scenarios were designed to reflect daily administration practices: direct administration of formulation; formulation co-administered with food and drinks, both immediately after mixing and 4 h after mixing. Drug dissolution was significantly affected by medicine co-administration with vehicles, compared to the direct administration of formulation. Furthermore, differences were observed on drug dissolution when the formulations were mixed with different vehicles of the same subtype. The time between preparation and testing of the drug-vehicle mixture also impacted dissolution behaviour. Drug dissolution was shown to be significantly affected by the physicochemical properties and composition of the vehicles, drug solubility in each vehicle and drug/formulation characteristics. Ultimately, in this study, we show the potential of age-appropriate in vitro dissolution testing as a useful biopharmaceutical tool for estimating drug dissolution in conditions relevant to the paediatric population. The setup developed has potential to evaluate the impact of medicine co-administration with vehicles on paediatric formulation performance.

Ghost-Pill-Buster: A Case Study of Intact Levetiracetam Extended-Release Tablets after Dissolution Testing

CNS Drugs ◽  
2016 ◽  
Vol 30 (5) ◽  
pp. 455-460
Author(s):  
Dajun Sun ◽  
Hong Wen ◽  
Anna Externbrink ◽  
Zongming Gao ◽  
David Keire ◽  
...  
Keyword(s):  
Extended Release ◽  
Dissolution Testing
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