Knowledge and awareness of adverse drug reactions and pharmacovigilance practices among healthcare professionals in Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia

Background: Adverse drug reactions (ADRs) represent important preventable causes of mortality, morbidity, hospitalization and increased healthcare costs. Traditionally, ADRs are studied in a clinical setting, but it is also important to estimate rates of ADRs in the community. The current study aimed to estimate population-based rates of ADRs in the community in the Kingdom of Saudi Arabia (KSA). Methods: A nationwide cross-sectional survey was conducted via registered pharmacists at community pharmacies across the 13 regions of KSA. The data were collected on an electronic online platform and included questions about participants’ demographics, health characteristics, experience with ADRs within the last 12 months and assess their knowledge about Saudi Food and Drug Authority (SFDA) reporting system. Results: Data collection was conducted between June and August 2018. Data from 5,228 surveys was analyzed. After weighting, the national annual rate of ADRs was estimated to be 28.00% (95% confidence interval 26.10% -30.00%). Of the respondents reporting an ADR, 371 (30.26%) reported that they were aware of the SFDA reporting system. Those who indicated they were aware, were asked if they had ever filed a report in the system; 53 (14.29%) said they had made a report. Conclusion: The results of this population-based estimates of community-based ADRs nationally in KSA showed that more than one quarter of the population had experienced ADR in the last 12 months. Future study is needed to better understand why these rates are higher in some regions than others, and what is needed to prevent high rates in subgroups such as women and those with chronic diseases.

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Knowledge, attitudes & practices of healthcare professionals in hospitals towards the reporting of adverse drug reactions in Saudi Arabia: A multi-centre cross sectional study

Saudi Pharmaceutical Journal ◽

10.1016/j.jsps.2018.04.012 ◽

2018 ◽

Vol 26 (7) ◽

pp. 925-931 ◽

Cited By ~ 6

Author(s):

Thamir M. AlShammari ◽

Mohammed J. Almoslem

Keyword(s):

Saudi Arabia ◽

Adverse Drug Reactions ◽

Healthcare Professionals ◽

Cross Sectional Study ◽

Sectional Study ◽

Drug Reactions ◽

Cross Sectional

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Knowledge about adverse drug reactions reporting among healthcare professionals in Nepal

International Journal of Risk & Safety in Medicine ◽

10.3233/jrs-120578 ◽

2013 ◽

Vol 25 (1) ◽

pp. 1-16 ◽

Cited By ~ 9

Author(s):

Santosh KC ◽

Pramote Tragulpiankit ◽

I. Ralph Edwards ◽

Sarun Gorsanan

Keyword(s):

Adverse Drug Reactions ◽

Healthcare Professionals ◽

Drug Reactions

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Processes and determinants of integration of eGFR in physicians’ drug prescriptions: a qualitative study of semi-structured interviews

Primary Health Care Research & Development ◽

10.1017/s1463423619000847 ◽

2019 ◽

Vol 20 ◽

Author(s):

Louis Lefèvre ◽

Maud Jourdain ◽

Jean-Pascal Fournier

Keyword(s):

Qualitative Study ◽

Adverse Drug Reactions ◽

Healthcare Professionals ◽

Drug Prescriptions ◽

Theory Approach ◽

Snowball Sampling ◽

Drug Reactions ◽

Structured Interviews ◽

Training Professional ◽

Grounded Theory Approach

Abstract Aim: Our objective was to explore the processes and determinants leading physicians to integrate estimated glomerular filtration rate (eGFR) in their drug prescriptions Background: Access to patients’ eGFR would allow primary care pharmacists to optimise their role in the procedure of safe prescribing. Some rare physicians actively integrate eGFR in their prescriptions, in a sporadically and uncoordinated manner. Methods: Qualitative study using semi-directed interviews conducted among 12 French physicians who integrated eGFR in their drug prescriptions, (February 2016–April 2017). These voluntary participants were recruited through different means: Twitter®, forums, direct contact and snowball sampling. Data analysis was based on the grounded theory approach, underpinned by a comprehensive perspective of interactionist orientation. Findings: Residency and training, professional experience – including experiences of adverse drug reactions – and the membership in various communities of professionals were key drivers for the integration of eGFR in prescriptions. The theoretical aim was above all safe prescribing in order to reduce adverse drug reactions, with the control by a dispensing pharmacist and/or other healthcare professionals. Nevertheless, none of the physicians had received any feedback from any healthcare professionals. Despite their disappointment, the physicians remained convinced of the interest of integrating eGFR in their prescriptions and would continue to do so. Characteristics associated with integration of eGFR in drug prescriptions belong partly to Roger’s theory of innovations. If a widespread diffusion of this habit takes place, it will be necessary to evaluate its adoption by both physicians and pharmacists.

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A Multi-Agent System for Reporting Suspected Adverse Drug Reactions

Online Journal of Public Health Informatics ◽

10.5210/ojphi.v6i3.5579 ◽

2014 ◽

Vol 6 (3) ◽

Author(s):

Yanqing Ji ◽

Fangyang Shen ◽

See-Yan Lau ◽

John Tran

Keyword(s):

Adverse Drug Reactions ◽

Healthcare Professionals ◽

Public Health Problem ◽

Reporting Rate ◽

Drug Reactions ◽

Data Mining Approach ◽

Spontaneous Reports ◽

Post Marketing ◽

Multi Agent ◽

Suspected Adverse Drug Reactions

Adverse drug reactions (ADRs) represent a serious worldwide public health problem. Current post-marketing ADR detection approaches largely rely on spontaneous reports filed by various healthcare professionals such as physicians, pharmacists et.al.. Underreporting is a serious deficiency of these methods - the actually reported adverse events represent less than 10% of all cases. Studies show that two important reasons that cause the underreporting are: 1) healthcare professionals are unaware of encountered ADRs, especially for those unusual ADRs; 2) they are too busy to voluntarily report ADRs since it takes a lot of time to fill out the reporting forms. This paper addresses these two issues by developing a multi-agent ADR reporting system. The system 1) helps healthcare professionals detect the potential causal relationship between a drug and an ADR by analyzing patients’ electronic records via both case-based analysis and statistical data mining approach; 2) allows healthcare professionals to add new rules to signal potential ADRs based on their medical expertise; 3) makes the reporting much easier by automatically linking the patients’ electronic data with the reporting form. A functioning prototype of the system has been developed. The proposed data analysis approaches as well as the performance of the system have been tested. The results indicate that this system has a great potential to improve the spontaneous reporting rate of suspected adverse drug reactions.

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STUDY TO EVALUATE SEVERE ADRS IN A TERTIARY CARE TEACHING HOSPITAL

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2017v9i5.22137 ◽

2017 ◽

pp. 55-58

Author(s):

A. R. Malahat ◽

C. Deepa Latha ◽

Sudhakar K. ◽

Deepika Baloju ◽

G. Vijayalakshmi

Keyword(s):

Adverse Drug Reactions ◽

Teaching Hospital ◽

Prospective Observational Study ◽

Healthcare Professionals ◽

Tertiary Care ◽

Care Centre ◽

Drug Reactions ◽

Tertiary Care Centre ◽

Tertiary Care Teaching Hospital ◽

Care Teaching

Objective: This study attempts to analyze the severe ADRs in a tertiary care centre and assess their seriousness, outcome, causality and severity. We emphasize on the need for reporting of ADRs by all healthcare professionals as it will reduce the burden of morbidity due to drugs and ensure better and more efficient healthcare. To analyse and evaluate the severe ADVERSE DRUG REACTIONs reported from various departments in a Tertiary care Teaching hospital.Methods: It is a prospective observational study that was carried out over a period of 6 mo (from July 2016 to December 2016) to assess the percentage of severe adverse drug reactions reported to the Pharmacovigilance cell of a tertiary care teaching hospital. The data collected included patientâ€™s demographic details, presenting complaints, clinical diagnosis and details of the drug(s) prescribed. The data was analysed for causality (as per the WHO-UMC scale) and severity (as per Hartwig and Siegel scale).Results: Out of 64 ADRs reported, 17 were serious. The majority of serious ADRs were categorized as probable (82.35%), whilst 1(5.8%) was categorized as possible and 2(11.76%) as certain in nature. The criteria for the majority of serious ADRs were hospitalization (%) followed by intervention to prevent permanent impairment or damage (%).Conclusion: The highest percentage of severe cases was reported with Antitubercular therapy (23.5%) followed by analgesics (23%) and anti epileptic agents (17.6%).

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The Role of Pharmacovigilance Center in Sudan in Reporting Adverse Drug Reactions

Pharmacoinformatics and Drug Discovery Technologies - Advances in Bioinformatics and Biomedical Engineering ◽

10.4018/978-1-4666-0309-7.ch021 ◽

2012 ◽

pp. 344-354

Author(s):

Abdalla Omer Elkhawad

Keyword(s):

Adverse Drug Reactions ◽

International Organizations ◽

Healthcare Professionals ◽

Drug Reactions ◽

Different Types ◽

Large Populations ◽

Pharmacovigilance Center

Pharmacovigilance is an active discipline, which is the study of structured mechanisms of the safety of medicines being used in clinical situations in large populations. In this chapter, the authors attempt to characterize the different types of Adverse Drug Reactions (ADRs) and related problems and mechanisms by which they cause harm to patients. They investigate the methods of detection of ADRs and various pharmacovigilance methods. The role and contributions of international organizations will be presented. The authors present the importance and need for education of healthcare professionals about pharmacovigilance and the proper reporting of ADRs for the purpose of efficient and safe use of medicines. The establishment of the Sudan pharmacovigilance center and how the system works will be discussed. Sources of data and actions taken since its inception are presented. The authors conclude by highlighting the problems and weaknesses of the system and ways to strengthen it.

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