Iron oxide nanoparticles: the Influence of synthesis method and size on composition and magnetic properties

AbstractMagnetic hyperthermia therapy (MHT) is a highly promising therapeutic modality for the treatment of different kinds of cancers and malignant tumors. The therapy is based on the concept that; iron oxide nanoparticles deposited at cancer sites can generate heat when exposed to an alternating current magnetic field or near infrared radiation and consequently destroying only the cancer cells by exploiting their vulnerability to heat. The fact that the treatment is at molecular level and that iron oxide nanoparticles provide more guided focus heating justifies its efficacy over treatment such as surgery, radiation therapy and chemotherapy. Nevertheless, the spread of MHT as the next-generation therapeutics has been shadowed by insufficient heating especially at the in vivo stage. This can be averted by modifying the iron oxide nanoparticle structure. To this end, various attempts have been made by developing a magnetic hybrid nanostructure capable of generating efficient heat. However, the synthesis method for each component (of the magnetic hybrid nanostructure) and the grafting process is now an issue. This has a direct effect on the performance of the magnetic hybrid nanostructure in MHT and other applications. The main objective of this review is to detail out the different materials, methods and characterization techniques that have been used so far in developing magnetic hybrid nanostructure. In view of this, we conducted a comprehensive review and present a road map for developing a magnetic hybrid nanostructure that is capable of generating optimum heat during MHT. We further summarize the various characterization techniques and necessary parameters to study in validating the efficiency of the magnetic hybrid nanostructure. Hopefully, this contribution will serve as a guide to researchers that are willing to evaluate the properties of their magnetic hybrid nanostructure.

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Comparative study on the magnetic properties of iron oxide nanoparticles loaded on mesoporous silica and carbon materials with different structure

Microporous and Mesoporous Materials ◽

10.1016/j.micromeso.2009.01.029 ◽

2009 ◽

Vol 121 (1-3) ◽

pp. 178-184 ◽

Cited By ~ 27

Author(s):

Sher Alam ◽

Chokkalingam Anand ◽

Radhakrishnan Logudurai ◽

Veerappan V. Balasubramanian ◽

Katsuhiko Ariga ◽

...

Keyword(s):

Magnetic Properties ◽

Iron Oxide ◽

Mesoporous Silica ◽

Comparative Study ◽

Iron Oxide Nanoparticles ◽

Carbon Materials ◽

Oxide Nanoparticles

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Photo-fluorescent and magnetic properties of iron oxide nanoparticles for biomedical applications

Nanoscale ◽

10.1039/c5nr01538c ◽

2015 ◽

Vol 7 (18) ◽

pp. 8209-8232 ◽

Cited By ~ 99

Author(s):

Donglu Shi ◽

M. E. Sadat ◽

Andrew W. Dunn ◽

David B. Mast

Keyword(s):

Magnetic Properties ◽

Iron Oxide ◽

Physical Properties ◽

Iron Oxide Nanoparticles ◽

Basic Science ◽

Biomedical Applications ◽

Oxide Nanoparticles ◽

Nanometer Range

Iron oxide exhibits fascinating physical properties especially in the nanometer range, not only from the standpoint of basic science, but also for a variety of engineering, particularly biomedical applications.

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Effect of synthesis conditions on the morphology, composition and magnetic properties of the Iron Oxide nanoparticles prepared via electric discharge method

Journal of Magnetism and Magnetic Materials ◽

10.1016/j.jmmm.2021.168090 ◽

2021 ◽

pp. 168090

Author(s):

Fatemeh Shahbazi ◽

Mohammad Noghani ◽

Reza Ahmadi

Keyword(s):

Magnetic Properties ◽

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Electric Discharge ◽

Oxide Nanoparticles ◽

Synthesis Conditions ◽

Discharge Method ◽

Electric Discharge Method

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Enhanced Collective Magnetic Properties in 2D Monolayers of Iron Oxide Nanoparticles Favored by Local Order and Local 1D Shape Anisotropy

Langmuir ◽

10.1021/acs.langmuir.5b04145 ◽

2016 ◽

Vol 32 (6) ◽

pp. 1621-1628 ◽

Cited By ~ 22

Author(s):

Delphine Toulemon ◽

Yu Liu ◽

Xavier Cattoën ◽

Cédric Leuvrey ◽

Sylvie Bégin-Colin ◽

...

Keyword(s):

Magnetic Properties ◽

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Shape Anisotropy ◽

Local Order ◽

Oxide Nanoparticles

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Iron-oxide nanoparticles by the green synthesis method using Moringa oleifera leaf extract for fluoride removal

Environmental Technology ◽

10.1080/09593330.2017.1369582 ◽

2017 ◽

Vol 39 (22) ◽

pp. 2926-2936 ◽

Cited By ~ 6

Author(s):

Carole Silveira ◽

Quelen Letícia Shimabuku ◽

Marcela Fernandes Silva ◽

Rosângela Bergamasco

Keyword(s):

Iron Oxide ◽

Green Synthesis ◽

Iron Oxide Nanoparticles ◽

Leaf Extract ◽

Moringa Oleifera ◽

Synthesis Method ◽

Fluoride Removal ◽

Oxide Nanoparticles

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Comparative study of magnetic properties and the anticancer effect of superparamagnetic and ferromagnetic iron oxide nanoparticles in the nanocomplex with doxorubicin

Reports of the National Academy of Sciences of Ukraine ◽

10.15407/dopovidi2015.09.113 ◽

2015 ◽

pp. 113-121

Author(s):

V.E. Orel ◽

◽

A.D. Shevchenko ◽

O.Yu. Rykhalskyi ◽

A.V. Romanov ◽

...

Keyword(s):

Magnetic Properties ◽

Iron Oxide ◽

Comparative Study ◽

Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Anticancer Effect ◽

Ferromagnetic Iron

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Effect of aluminum doped iron oxide nanoparticles on magnetic properties of the polyacrylonitrile nanofibers

Journal of Polymer Engineering ◽

10.1515/polyeng-2015-0303 ◽

2017 ◽

Vol 37 (2) ◽

pp. 135-141

Author(s):

Armin Ourang ◽

Soheil Pilehvar ◽

Mehrzad Mortezaei ◽

Roya Damircheli

Keyword(s):

Magnetic Properties ◽

Iron Oxide ◽

Magnetic Nanoparticles ◽

Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Negative Interaction ◽

Magnetic Nanofibers

Abstract In this work, polyacrylonitrile (PAN) was electrospun with and without magnetic nanoparticles (aluminum doped iron oxide) and was turned into magnetic nanofibers. The results showed that nanofibers diameter decreased from 700 nm to 300 nm by adding nanoparticles. Furthermore, pure PAN nanofibers were indicated to have low magnetic ability due to polar bonds that exist in their acrylonitrile groups. Obviously by adding only 4 wt% of the nanoparticles to PAN nanofibers, magnetic ability soared by more than 10 times, but at a higher percentage, it was shown to change just a little due to negative interaction among nanoparticles. This event relates to antiferromagnetically coupling of nanoparticles due to incomplete dispersion at higher percentage.

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Dendrimer Mediated ‘Bricks and Mortar’ Self-Assembly of Nanoparticles

MRS Proceedings ◽

10.1557/proc-739-h7.38 ◽

2002 ◽

Vol 739 ◽

Author(s):

Benjamin L. Frankamp ◽

Andrew K. Boal ◽

Vincent M. Rotello

Keyword(s):

Magnetic Properties ◽

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Self Assembly ◽

Quantum Interference ◽

Pamam Dendrimers ◽

Interparticle Spacing ◽

Blocking Temperature ◽

Oxide Nanoparticles ◽

Particle Spacing

ABSTRACTControl of particle-particle spacing is a key determinant of optical, electronic, and magnetic properties of nanocomposite materials. We have used poly(amidoamine) (PAMAM) dendrimers to assemble carboxylic acid-functionalized mixed monolayer protected clusters (MMPCs) through acid/base chemistry between particle and polymer. IR spectroscopy and selective dendrimer staining, observed by Transmission Electron Microscopy (TEM), establish that the PAMAM dendrimers are the mortar in the assembly and act to space the MMPCs in the resulting aggregates. Small angle X-ray scattering (SAXS) was then used to establish average interparti cle distances; five generations of PAMAM dendrimer (0, 1, 2, 4, 6) were investigated and monotonic increase in interparticle spacing from 4.1 nm to 6.1 nm was observed.Initial studies involving the application of this methodology to control the magnetic properties of 3-iron oxide nanoparticles have been completed. γ-Iron oxide nanoparticles (6.5 nm in diameter) have been assembled with PAMAM dendrimers generations 2.5, 4.5, and 6.5. The resulting aggregates were characterized with SAXS and magnetization obtained on a super conducting quantum interference devise (SQUID). An observed correlation between the blocking temperature (TB) and the average interparticle spacing suggests that our methodology could be used to tailor the magnetic profile of the nanoparticles.

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