scholarly journals m-CF3-substituted diphenyl diselenide attenuates all phases of morphine-induced behavioral locomotor sensitization in mice

2021 ◽  
pp. 126889
Author(s):  
Renata F. Rodrigues ◽  
Bruna C.W. Fulco ◽  
Cristina W. Nogueira
Keyword(s):  
Locomotor Sensitization ◽  
Diphenyl Diselenide

scholarly journals Catalytic Antioxidant Activity of Bis-Aniline-Derived Diselenides as GPx Mimics

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4446
Author(s):  
Giancarlo V. Botteselle ◽  
Welman C. Elias ◽  
Luana Bettanin ◽  
Rômulo F. S. Canto ◽  
Drielly N. O. Salin ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Hydrogen Bond ◽  
Electronic Properties ◽  
Partial Charge ◽  
Amino Group ◽  
Diphenyl Diselenide ◽  
Charge Delocalization ◽  
Ipso Substitution ◽  
Efficient Route ◽  
Catalytic Performances

Herein, we describe a simple and efficient route to access aniline-derived diselenides and evaluate their antioxidant/GPx-mimetic properties. The diselenides were obtained in good yields via ipso-substitution/reduction from the readily available 2-nitroaromatic halides (Cl, Br, I). These diselenides present GPx-mimetic properties, showing better antioxidant activity than the standard GPx-mimetic compounds, ebselen and diphenyl diselenide. DFT analysis demonstrated that the electronic properties of the substituents determine the charge delocalization and the partial charge on selenium, which correlate with the catalytic performances. The amino group concurs in the stabilization of the selenolate intermediate through a hydrogen bond with the selenium.

Diphenyl diselenide protects motor neurons through inhibition of microglia-mediated inflammatory injury in amyotrophic lateral sclerosis

2021 ◽  
Vol 165 ◽  
pp. 105457
Author(s):  
Chunting Zhang ◽  
Hongyong Wang ◽  
Weiwei Liang ◽  
Yueqing Yang ◽  
Chaohua Cong ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Neurons ◽  
Diphenyl Diselenide ◽  
Inflammatory Injury ◽  
Lateral Sclerosis

Resistance of neuronal nitric oxide synthase-deficient mice to cocaine-induced locomotor sensitization

1998 ◽  
Vol 140 (3) ◽  
pp. 378-386 ◽  
Author(s):  
Y. Itzhak ◽  
Syed F. Ali ◽  
Julio L. Martin ◽  
M. Dean Black ◽  
Paul L. Huang
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Locomotor Sensitization ◽  
Oxide Synthase ◽  
Deficient Mice

Clozapine inhibits development and expression of nicotine-induced locomotor sensitization in rats

Synapse ◽  
2009 ◽  
Vol 63 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Hakan Kayir ◽  
Gokhan Goktalay ◽  
Murat Yildirim ◽  
Tayfun I. Uzbay
Keyword(s):  
Locomotor Sensitization

Repeated heroin in rats produces locomotor sensitization and enhances appetitive Pavlovian and instrumental learning involving food reward

2009 ◽  
Vol 91 (3) ◽  
pp. 351-357 ◽  
Author(s):  
Robert Ranaldi ◽  
Jonathan Egan ◽  
Karen Kest ◽  
Matthew Fein ◽  
Andrew R. Delamater
Keyword(s):  
Food Reward ◽  
Instrumental Learning ◽  
Locomotor Sensitization
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