PD29-12 COMPARISON OF ONCOLOGICAL OUTCOMES OF DISTAL URETERAL ≤PT2 UROTHELIAL CARCINOMA MANAGED BY NEPHROURETERECTOMY, SEGMENTAL URETERECTOMY OR ENDOSCOPIC SURGERY

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Laurent Nison ◽  
Pierre Colin ◽  
Mesut Remzi ◽  
Shahrokh F. Shariat ◽  
Tobias Klatte ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Endoscopic Surgery ◽  
Oncological Outcomes ◽  
Segmental Ureterectomy

scholarly journals Segmental ureterectomy can be performed safely in patients with urothelial carcinoma of distal ureter

2018 ◽  
Vol 13 (7) ◽  
Author(s):  
Zhuo Jia ◽  
Yanqing Gong ◽  
Cuijian Zhang ◽  
Zhengqing Bao ◽  
Xuesong Li ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Urothelial Carcinoma ◽  
Distant Metastasis ◽  
Cox Regression ◽  
Recurrence Free Survival ◽  
Distal Ureter ◽  
Free Survival ◽  
Oncological Outcomes ◽  
Distant Metastasis Free Survival ◽  
Segmental Ureterectomy

Introduction: We aimed to compare oncological outcomes by surgery type (segmental ureterectomy [SU] vs. radical nephroureterectomy [RNU]) in a large cohort of patients with upper tract urothelial carcinoma (UTUC) of the distal ureter.Methods: We performed a retrospective analysis of 219 patients with UTUC of the distal ureter among 931 patients with UTUC who underwent SU and RNU. Clinicopathological outcomes were evaluated. Cancer-specific survival (CSS), overall survival (OS), local recurrence-free survival (RFS), intravesical recurrence-free survival (IVRFS), contralateral recurrence-free survival, and distal metastasis-free survival were assessed by the Kaplan-Meier method and Cox regression, estimating hazard ratios (HR) and 95% confidence intervals (CIs).Results: A total of 179 (81.7%) patients underwent RNU and 40 (18.3%) underwent SU: 85 males (47.5%) with RNU and 17 (42.5%) with SU (p=0.568). The median age with RNU and SU was 71 years (range 31–86) and 70 years (range 46–90), respectively (p=0.499). The T stage of the two groups did not differ (p=0.122), nor did mean tumour length (3.35±2.62 vs. 3.25±2.14; p=0.953), grade (p=0.075), tumour necrosis (p=0.634), or followup time (months) (58.1±8.1 vs. 63.7±3.4; p=0.462). The two groups did not differ in CSS (p=0.358) or OS (p=0.206), and surgery type did not predict CSS (HR 0.862; 95% CI 0.469–1.585; p=0.633) or OS (HR 0.764; 95% CI 0.419–1.392; p=0.379). Local RFS was higher with RNU than SU (96.2% vs. 86.0%; p=0.02), but the groups did not differ in IVRFS (p=0.661), contralateral RFS (p=0.183), or distant metastasis-free survival (p=0.078). On multivariate analysis, SU was associated with local RFS (HR 5.069; 95% CI 1.029–24.968; p=0.046) and distant metastasis-free survival (HR 6.497; 95% CI 1.196–35.283; p=0.03). Local RFS was lower with SU than RNU for patients with pT3–4 stage (p=0.006).Conclusions: Long-term oncological outcomes were equivalent with SU and RNU in patients with UTUC of the distal ureter. SU affected local recurrence survival, especially with advanced tumour stage, and distant metastasis survival.

scholarly journals Comparison of oncologic and functional outcomes between radical nephroureterectomy and segmental ureterectomy for upper urinary tract urothelial carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tae Heon Kim ◽  
Chung Un Lee ◽  
Minyong Kang ◽  
Hwang Gyun Jeon ◽  
Byong Chang Jeong ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Functional Outcomes ◽  
Upper Urinary Tract ◽  
Rank Test ◽  
Radical Nephroureterectomy ◽  
Free Survival ◽  
Significant Difference ◽  
Segmental Ureterectomy ◽  
Urinary Tract Urothelial Carcinoma

AbstractThis study aims to compare oncologic and functional outcomes after radical nephroureterectomy (RNU) and segmental ureterectomy (SU) in patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively collected data on patients who underwent either RNU or SU of UTUC. Propensity score matching was performed among 394 cases to yield a final cohort of 40 RNU and 40 SU cases. Kaplan–Meier analysis and the log-rank test were used to compare overall survival (OS), cancer-specific survival (CSS), progression-free survival (PFS), and intravesical recurrence-free survival (IVRFS) between the groups. We also compared the change in postoperative estimated glomerular filtration rate (eGFR). There was no significant difference in terms of CSS, PFS, and IVRFS between the RNU and SU groups, but the RNU group had a better OS than the SU group (p = 0.032). Postoperative eGFR was better preserved in the SU group than in the RNU group (p < 0.001). SU provides comparable CSS, PFS, and IVRFS for patients with UTUC compared to RNU, even in patients with advanced-stage and/or high-grade cancer. Further, SU achieves better preservation of renal function.

scholarly journals Incidences and oncological outcomes of urothelial carcinoma in kidney transplant recipients

2018 ◽  
Vol Volume 11 ◽  
pp. 157-166 ◽  
Author(s):  
Jiwoong Yu ◽  
Chung Un Lee ◽  
Minyong Kang ◽  
Hwang Gyun Jeon ◽  
Byong Chang Jeong ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Oncological Outcomes

Impact of body mass index on the oncological outcomes of patients treated with radical nephroureterectomy for upper tract urothelial carcinoma

2017 ◽  
Vol 36 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Yohann Dabi ◽  
Mohammed El Mrini ◽  
Igor Duquesnes ◽  
Nicolas Barry Delongchamps ◽  
Mathilde Sibony ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Urothelial Carcinoma ◽  
Body Mass ◽  
Upper Tract Urothelial Carcinoma ◽  
Radical Nephroureterectomy ◽  
Upper Tract ◽  
Oncological Outcomes

Oncological outcomes of neoadjuvant chemotherapy in patients with locally advanced upper tract urothelial carcinoma: A multicenter study.

2018 ◽  
Vol 36 (6_suppl) ◽  
pp. 429-429
Author(s):  
Shingo Hatakeyama ◽  
Yuka Kubota ◽  
Hayato Yamamoto ◽  
Takahiro Yoneyama ◽  
Yasuhiro Hashimoto ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Neoadjuvant Chemotherapy ◽  
Urothelial Carcinoma ◽  
Lymphovascular Invasion ◽  
Cox Regression ◽  
Locally Advanced ◽  
Upper Tract Urothelial Carcinoma ◽  
Cancer Specific Survival ◽  
Cox Regression Analysis ◽  
Oncological Outcomes

429 Background: The clinical impact of neoadjuvant chemotherapy (NAC) on oncological outcomes in patients with locally advanced upper tract urothelial carcinoma (UTUC) remains unclear. We investigated the oncological outcomes of platinum-based NAC for locally advanced UTUC. Methods: A total of 426 patients who underwent radical nephroureterectomy at five medical centers between January 1995 and April 2017 were examined retrospectively. Of the 426 patients, 234 were treated for a high-risk disease (stages cT3–4 or locally advanced [cN+] disease) with or without NAC. NAC regimens were selected based on eligibility of cisplatin. We retrospectively evaluated post-therapy pathological downstaging, lymphovascular invasion, and prognosis stratified by NAC use. Multivariate Cox regression analysis was performed for independent factors for prognosis. Results: Of 234 patients, 101 received NAC (NAC group) and 133 did not (Control [Ctrl] group). The regimens in the NAC group included gemcitabine and carboplatin (75%), and gemcitabine and cisplatin (21%). Pathological downstagings of the primary tumor and lymphovascular invasion were significantly improved in the NAC than in the Ctrl groups. NAC for locally advanced UTUC significantly prolonged recurrence-free and cancer-specific survival. Multivariate Cox regression analysis using an inverse probability of treatment weighted (IPTW) method showed that NAC was selected as an independent predictor for prolonged recurrence-free and cancer-specific survival. However, the influence of NAC on overall survival was not statistically significant. Conclusions: Platinum-based NAC for locally advanced UTUC potentially improves oncological outcomes. Further prospective studies are needed to clarify the clinical benefit of NAC for locally advanced UTUC.

scholarly journals The oncological outcomes after pluck method laparoscopic nephroureterectomy for upper tract urothelial carcinoma

2016 ◽  
Vol 27 (2) ◽  
pp. S45
Author(s):  
Jen-Shu Tseng ◽  
Chih-Chiao Lee ◽  
Ting-Po Lin ◽  
Marcelo Chen ◽  
Huang-Kuang Chang ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Upper Tract Urothelial Carcinoma ◽  
Upper Tract ◽  
Oncological Outcomes ◽  
Laparoscopic Nephroureterectomy
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