Combined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats

Life Sciences ◽  
2018 ◽  
Vol 199 ◽  
pp. 158-166 ◽  
Author(s):  
Ariclecio Cunha de Oliveira ◽  
Sandra Andreotti ◽  
Rogério António Laurato Sertie ◽  
Amanda Baron Campana ◽  
André Ricardo Gomes de Proença ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glycemic Control ◽  
White Adipose Tissue ◽  
Combined Treatment ◽  
Male Rats ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Reproductive Axis

scholarly journals Metabolism and secretory function of white adipose tissue: effect of dietary fat

2009 ◽  
Vol 81 (3) ◽  
pp. 453-466 ◽  
Author(s):  
Cláudia M. Oller do Nascimento ◽  
Eliane B. Ribeiro ◽  
Lila M. Oyama
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
White Adipose Tissue ◽  
Dietary Fat ◽  
Dietary Fatty Acids ◽  
Secretory Function ◽  
High Fat ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism

Approximately 40% of the total energy consumed by western populations is represented by lipids, most of them being ingested as triacylglycerols and phospholipids. The focus of this review is to analyze the effect of the type of dietary fat on white adipose tissue metabolism and secretory function, particularly on haptoglobin, TNF-α, plasminogen activator inhibitor-1 and adiponectin secretion. Previous studies have demonstrated that the duration of the exposure to the high-fat feeding, amount of fatty acid present in the diet and the type of fatty acid may or may not have a significant effect on adipose tissue metabolism. However, the long-term or short-term high fat diets, especially rich in saturated fatty acids, probably by activation of toll-like receptors, stimulated the expression of proinflammatory adipokines and inhibited adiponectin expression. Further studies are needed to investigate the cellular mechanisms by which dietary fatty acids affect white adipose tissue metabolism and secretory functions.

scholarly journals Anti-Obesity Effects of Soybean Embryo Extract and Enzymatically-Modified Isoquercitrin

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1394
Author(s):  
Minsu Kim ◽  
Seowoo Im ◽  
Yoon keun Cho ◽  
Cheoljun Choi ◽  
Yeonho Son ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Molecular Mechanisms ◽  
Body Weight Gain ◽  
Combined Treatment ◽  
Brown Adipocyte ◽  
Mitochondrial Content ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Embryo Extract ◽  
Upregulated Genes

Soy isoflavones are bioactive phytoestrogens with known health benefits. Soybean embryo extract (SEE) has been consumed as a source of isoflavones, mainly daidzein, glycitein, and genistein. While previous studies have reported the anti-obesity effects of SEE, this study investigates their molecular mechanisms and the synergistic effects of co-treatment with SEE and enzymatically modified isoquercitrin (EMIQ). SEE upregulated genes involved in lipolysis and brown adipocyte markers and increased mitochondrial content in differentiated C3H10T1/2 adipocytes in vitro. Next, we use a high-fat diet-induced obesity mouse model to determine the anti-obesity effect of SEE. Two weeks of single or combined treatment with SEE and EMIQ significantly reduced body weight gain and improved glucose tolerance. Mechanistically, SEE treatment increased mitochondrial content and upregulated genes involved in lipolysis in adipose tissue through the cAMP/PKA-dependent signaling pathway. These effects required a cytosolic lipase adipose triglyceride lipase (ATGL) expression, confirmed by an adipocyte-specific ATGL knockout mouse study. Collectively, this study demonstrates that SEE exerts anti-obesity effects through the activation of adipose tissue metabolism and exhibits a synergistic effect of co-treatment with EMIQ. These results improve our understanding of the mechanisms underlying the anti-obesity effects of SEE related to adipose tissue metabolism.

Remodeling of white adipose tissue metabolism by physical training prevents insulin resistance

Life Sciences ◽  
2014 ◽  
Vol 103 (1) ◽  
pp. 41-48 ◽  
Author(s):  
T.S. Higa ◽  
A.V. Spinola ◽  
M.H. Fonseca-Alaniz ◽  
F.S. Evangelista
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Physical Training ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism

Measurements of White Adipose Tissue Metabolism by Microdialysis Technique

2003 ◽  
pp. 305-321
Author(s):  
Pierre Barbe ◽  
Christian Darimont ◽  
Perla Saint-Marc ◽  
Jean Galitzky
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism

scholarly journals Changes in white adipose tissue metabolism induced by resveratrol in rats

2011 ◽  
Vol 8 (1) ◽  
pp. 29 ◽  
Author(s):  
Goiuri Alberdi ◽  
Víctor M Rodríguez ◽  
Jonatan Miranda ◽  
María T Macarulla ◽  
Noemí Arias ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism

scholarly journals Enhanced White Adipose Tissue Metabolism in Iatrogenic Cushing's Syndrome With FDG PET/CT

2014 ◽  
Vol 99 (9) ◽  
pp. 3041-3042 ◽  
Author(s):  
David A. Pattison ◽  
Michael S. Hofman ◽  
Eddie Lau ◽  
Rob Ware ◽  
Rodney J. Hicks
Keyword(s):  
Adipose Tissue ◽  
Cushing’S Syndrome ◽  
White Adipose Tissue ◽  
Fdg Pet ◽  
Cushing's Syndrome ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Iatrogenic Cushing’S Syndrome

scholarly journals The confounding effects of sub-thermoneutral housing temperatures on aerobic exercise-induced adaptations in mouse subcutaneous white adipose tissue

2021 ◽  
Vol 17 (6) ◽  
pp. 20210171
Author(s):  
Greg L. McKie ◽  
David C. Wright
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Model Organism ◽  
Human Biology ◽  
Thermal Biology ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Subcutaneous White Adipose Tissue ◽  
Housing Temperature ◽  
Exercise Induced

Mice are the most commonly used model organism for human biology, and failure to acknowledge fundamental differences in thermal biology between these species has confounded the study of adipose tissue metabolism in mice and its translational relevance to humans. Here, using exercise biochemistry as an example, we highlight the subtle yet detrimental effects sub-thermoneutral housing temperatures can have on the study of adipose tissue metabolism in mice. We encourage academics and publishers to consider ambient housing temperature as a key determinant in the methodological conception and reporting of all research on rodent white adipose tissue metabolism.

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