RAP-8 ameliorates liver fibrosis by modulating cell cycle and oxidative stress

Life Sciences ◽  
2019 ◽  
Vol 229 ◽  
pp. 200-209 ◽  
Author(s):  
Hongjiao Xu ◽  
Sihua Hong ◽  
Zhibin Yan ◽  
Qian Zhao ◽  
Ying Shi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Liver Fibrosis ◽  
And Oxidative Stress

Hydrogen peroxide and quercetin induced changes on cell viability, apoptosis and oxidative stress in HepG2 cells

2020 ◽  
Vol 01 ◽  
Author(s):  
Ayşe Mine Yılmaz ◽  
Gökhan Biçim ◽  
Kübra Toprak ◽  
Betül Karademir Yılmaz ◽  
Irina Milisav ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Hydrogen Peroxide ◽  
Cell Viability ◽  
Hepg2 Cells ◽  
Proteasome Activity ◽  
Cell Cycle Phases ◽  
Induced Changes ◽  
And Oxidative Stress ◽  
Quercetin Treatment

Background: Different cellular responses influence the progress of cancer. In this study, we have investigated the effect of hydrogen peroxide and quercetin induced changes on cell viability, apoptosis and oxidative stress in human hepatocellular carcinoma (HepG2) cells. Methods: The effects of hydrogen peroxide and quercetin on cell viability, cell cycle phases and oxidative stress related cellular changes were investigated. Cell viability was assessed by WST-1 assay. Apoptosis rate, cell cycle phase changes and oxidative stress were measured by flow cytometry. Protein expressions of p21, p27, p53, NF-Kβ-p50 and proteasome activity were determined by Western blot and fluorometry, respectively. Results: Hydrogen peroxide and quercetin treatment resulted in decreased cell viability and increased apoptosis in HepG2 cells. Proteasome activity was increased by hydrogen peroxide but decreased by quercetin treatment. Conclusion: Both agents resulted in decreased p53 protein expression and increased cell death by different mechanisms regarding proteostasis and cell cycle phases.

Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis

2021 ◽  
Vol 12 (5) ◽  
pp. 2323-2334
Author(s):  
Shihong Zheng ◽  
Peichang Cao ◽  
Zequn Yin ◽  
Xuerui Wang ◽  
Yuanli Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Liver Fibrosis ◽  
Liver Damage ◽  
Liver Diseases ◽  
Potential Drug ◽  
Abnormal Lipid Metabolism ◽  
And Oxidative Stress

Apigenin prevented the DDC-induced abnormal lipid metabolism, liver damage and liver fibrosis by reducing inflammation and oxidative stress. Apigenin might be a potential drug for the treatment of cholestatic liver diseases.

scholarly journals Hypoxia-induced myocardial regeneration

2017 ◽  
Vol 123 (6) ◽  
pp. 1676-1681 ◽  
Author(s):  
Wataru Kimura ◽  
Yuji Nakada ◽  
Hesham A. Sadek
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Systolic Heart Failure ◽  
Cardiac Regeneration ◽  
Oxygen Metabolism ◽  
Functional Improvement ◽  
Cardiomyocyte Proliferation ◽  
Mammalian Heart ◽  
Cell Cycle Reentry ◽  
And Oxidative Stress

The underlying cause of systolic heart failure is the inability of the adult mammalian heart to regenerate damaged myocardium. In contrast, some vertebrate species and immature mammals are capable of full cardiac regeneration following multiple types of injury through cardiomyocyte proliferation. Little is known about what distinguishes proliferative cardiomyocytes from terminally differentiated, nonproliferative cardiomyocytes. Recently, several reports have suggested that oxygen metabolism and oxidative stress play a pivotal role in regulating the proliferative capacity of mammalian cardiomyocytes. Moreover, reducing oxygen metabolism in the adult mammalian heart can induce cardiomyocyte cell cycle reentry through blunting oxidative damage, which is sufficient for functional improvement following myocardial infarction. Here we concisely summarize recent findings that highlight the role of oxygen metabolism and oxidative stress in cardiomyocyte cell cycle regulation, and discuss future therapeutic approaches targeting oxidative metabolism to induce cardiac regeneration.

scholarly journals Ameliorative Effects of Nilotinib on CCl4 Induced Liver Fibrosis Via Attenuation of RAGE/HMGB1 Gene Expression and Oxidative Stress in Rat

2017 ◽  
Vol 53 (2) ◽  
pp. 118 ◽  
Author(s):  
Vahid Khanjarsim ◽  
Jamshid Karimi ◽  
Iraj Khodadadi ◽  
Adel Mohammadalipour ◽  
Mohammad Taghi Goodarzi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Liver Fibrosis ◽  
And Oxidative Stress

Radiation Response of Neural Precursor Cells: Linking Cellular Sensitivity to Cell Cycle Checkpoints, Apoptosis and Oxidative Stress

2004 ◽  
Vol 161 (1) ◽  
pp. 17-27 ◽  
Author(s):  
Charles L. Limoli ◽  
Erich Giedzinski ◽  
Radoslaw Rola ◽  
Shinji Otsuka ◽  
Theo D. Palmer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Precursor Cells ◽  
Cell Cycle Checkpoints ◽  
Neural Precursor Cells ◽  
Radiation Response ◽  
Neural Precursor ◽  
Cellular Sensitivity ◽  
And Oxidative Stress

scholarly journals Dandelion prevents liver fibrosis, inflammatory response, and oxidative stress in rats

2020 ◽  
Vol 81 (1) ◽  
Author(s):  
Alaaeldin Ahmed Hamza ◽  
Mona Gamel Mohamed ◽  
Fawzy Mohamed Lashin ◽  
Amr Amin
Keyword(s):  
Oxidative Stress ◽  
Liver Fibrosis ◽  
Inflammatory Response ◽  
And Oxidative Stress

1,8-Cineole promotes G0/G1 cell cycle arrest and oxidative stress-induced senescence in HepG2 cells and sensitizes cells to anti-senescence drugs

Life Sciences ◽  
2020 ◽  
Vol 243 ◽  
pp. 117271 ◽  
Author(s):  
Boris Rodenak-Kladniew ◽  
Agustina Castro ◽  
Peter Stärkel ◽  
Marianela Galle ◽  
Rosana Crespo
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Hepg2 Cells ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
And Oxidative Stress

scholarly journals Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

Aging Cell ◽  
2016 ◽  
Vol 16 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Lisa A. Lesniewski ◽  
Douglas R. Seals ◽  
Ashley E. Walker ◽  
Grant D. Henson ◽  
Mark W. Blimline ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Vascular Dysfunction ◽  
Nutrient Sensing ◽  
Age Related ◽  
And Oxidative Stress

INHIBITION OF THE RENIN?ANGIOTENSIN SYSTEM ATTENUATES THE DEVELOPMENT OF LIVER FIBROSIS AND OXIDATIVE STRESS IN RATS

2007 ◽  
Vol 0 (0) ◽  
pp. 070928213402001-??? ◽  
Author(s):  
Ebtehal El-Demerdash ◽  
Omar M Abdel Salam ◽  
Seham A El-Batran ◽  
Heba MI Abdallah ◽  
Nermeen M Shaffie
Keyword(s):  
Oxidative Stress ◽  
Liver Fibrosis ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
And Oxidative Stress
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