scholarly journals 4D printing of polymeric materials for tissue and organ regeneration

2017 ◽  
Vol 20 (10) ◽  
pp. 577-591 ◽  
Author(s):  
Shida Miao ◽  
Nathan Castro ◽  
Margaret Nowicki ◽  
Lang Xia ◽  
Haitao Cui ◽  
...  
2019 ◽  
Author(s):  
◽  
Jheng-Wun Su

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Learning from nature livings, especially those that can respond to the stimuli and change the shape, is attracting increasing interests in a wide variety of research fields. There is a significant need of developing synthetic materials that can mimic these living systems to show dynamic and adaptive shape-changing functions. Although various fabrication methods including molding, micro-fabrication and photolithography have been developed to fabricate the dynamic materials, they all have shown some limits. At present, 3D printing is a promising technique, which provides a cost effective, accurate and customized method to form 3D structures. The recently new emerging technique, 4D printing, which employs the 3D printing to print the active materials for dynamic 3D structures, shows a great potential for various applications such as tissue engineering, flexible electronics, and soft robotics. Despite much recent progress, this technology and its application in 3D dynamic structure fabrication is still in its infancy. My Ph.D. dissertation focuses on 4D printing of programmable polymeric materials that exhibits complex, reversible, shape transformations as well as enriching the printable material library by exploring various active materials for 4D printing technology. Chapter 1 introduces the current development of active materials and methodologies. Much attention is paid to the recent progress and its merits and demerits. Chapter 2 presents a simple and inexpensive 4D printing of waterborne polyurethane paint (PU) composites that are fabricated by mixing PU with micro-size preswollen carboxymethyl cellulose (CMC) and silicon oxide nanoparticle (NPs), respectively. Chapter 3 presents the 4D printing of a commercial polymer, SU-8, which has yet been reported in this field. The self-morphing behaviors of the printed SU-8 structures are induced by spatial control of swelling medium inside the SU-8 matrix. In Chapter 4, machine learning algorithms are applied to evaluate the shape-morphing behaviors of 4D printed objects. After the model optimization by tuning the hyperparameters the obtained machine learning models enable to accurately predict the final curvatures and curving angles of the 4D printed SU-8 structures from given input geometrical information. This initial success show that these data-driven surrogate models can well circumvent the challenge of human centered trial-and-error process in optimizing the printed structures, thereby pushing the research in 4D printing to a new height.


Author(s):  
Peng Fu ◽  
Haimei Li ◽  
Jin Gong ◽  
Zengjie Fan ◽  
Andrew T. Smith ◽  
...  

2019 ◽  
Vol 63 (4) ◽  
pp. 532-544 ◽  
Author(s):  
SuQian Ma ◽  
YunPeng Zhang ◽  
Meng Wang ◽  
YunHong Liang ◽  
Lei Ren ◽  
...  

2020 ◽  
Vol 05 ◽  
Author(s):  
Smita Nayak ◽  
Bhaskar Vaidhun ◽  
Kiran Kedar

In the last few decades, as understanding of polymers grew, their applications in healthcare gained prominence. However, their widespread use was limited due to inevitable ageing, unavoidable degradation and excessive wear and tear. In order to overcome this drawback, researchers took inspiration from the capability of the human body to heal itself. Sci-entific curiosity and focussed efforts in this direction have laid the foundation for successful conceptualization of self-healing polymeric biomaterials and their commercial utilization for ancillary purposes. This review familiarizes the readers with recent literature in self-healing polymers, their fabrication techniques as well as applications in medical and pharma-ceutical arenas. It is heartening to note that these polymeric materials have overcome the disadvantages of conventional polymers and shown immense promise in breakthrough technologies such as tissue engineering, anti-biofouling as well as 3D and 4D printing. Self -healing polymers are poised to become critical supporting biomaterials in traditional disciplines such as orthopaedics, dentistry and pharmaceutical drug delivery. Efforts are on to design novel self-healing materials that meet the regulatory requirements of safety and biocompatibility. Research trends indicate that self-healing polymers may play a pivotal supportive role in furthering advances in therapeutics. The authors have, through this review, attempted to spark interest and stimulate creative minds to work in this domain.


Author(s):  
Carmen M. González-Henríquez ◽  
Fernando E. Rodriguez-Umanzor ◽  
Mauricio A. Sarabia-Vallejos ◽  
Juan Rodriguez-Hernandez

Proceedings ◽  
2020 ◽  
Vol 57 (1) ◽  
pp. 71
Author(s):  
Laura-Nicoleta Dragomir ◽  
Augusta Raluca Gabor ◽  
Ștefan-Ovidiu Dima ◽  
Doina Dimonie

Smart polymeric materials with shape memory are those materials that exist [...]


Polymers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1864 ◽  
Author(s):  
Ming-You Shie ◽  
Yu-Fang Shen ◽  
Suryani Dyah Astuti ◽  
Alvin Kai-Xing Lee ◽  
Shu-Hsien Lin ◽  
...  

The purpose of 4D printing is to embed a product design into a deformable smart material using a traditional 3D printer. The 3D printed object can be assembled or transformed into intended designs by applying certain conditions or forms of stimulation such as temperature, pressure, humidity, pH, wind, or light. Simply put, 4D printing is a continuum of 3D printing technology that is now able to print objects which change over time. In previous studies, many smart materials were shown to have 4D printing characteristics. In this paper, we specifically review the current application, respective activation methods, characteristics, and future prospects of various polymeric materials in 4D printing, which are expected to contribute to the development of 4D printing polymeric materials and technology.


2019 ◽  
Vol 3 (3) ◽  
pp. 111-113
Author(s):  
Heon Ju Lee

In this exclusive interview, Heon Ju Lee discusses ROCKIT healthcare’s novel bioprinting technique used to treat patients with dermal scarring. This interview was conducted by Mike Gregg, Commissioning Editor of the Journal of 3D Printing in Medicine. Dr Heon Ju Lee is the Chief Technology Officer and Managing Director of ROKIT. He is developing the service platform technology for artificial organ regeneration and supervises the overseas business development for the propagation of such service platforms. The focus of these platforms, bringing bio 3D print-based medical therapies into the operating room, on tissues that are relatively easy to fabricate structurally with the current technology, this includes skin, cartilage, hair, retina and heart patch regeneration. Dr Lee has a PhD from MIT in mechanical engineering and has been working as a 3D/4D printing group leader at KIST.


Author(s):  
D. L. Misell

In the electron microscopy of biological sections the adverse effect of chromatic aberration on image resolution is well known. In this paper calculations are presented for the inelastic and elastic image intensities using a wave-optical formulation. Quantitative estimates of the deterioration in image resolution as a result of chromatic aberration are presented as an alternative to geometric calculations. The predominance of inelastic scattering in the unstained biological and polymeric materials is shown by the inelastic to elastic ratio, I/E, within an objective aperture of 0.005 rad for amorphous carbon of a thickness, t=50nm, typical of biological sections; E=200keV, I/E=16.


Author(s):  
Martin J. Mahon ◽  
Patrick W. Keating ◽  
John T. McLaughlin

Coatings are applied to appliances, instruments and automobiles for a variety of reasons including corrosion protection and enhancement of market value. Automobile finishes are a highly complex blend of polymeric materials which have a definite impact on the eventual ability of a car to sell. Consumers report that the gloss of the finish is one of the major items they look for in an automobile.With the finish being such an important part of the automobile, there is a zero tolerance for paint defects by auto assembly plant management. Owing to the increased complexity of the paint matrix and its inability to be “forgiving” when foreign materials are introduced into a newly applied finish, the analysis of paint defects has taken on unparalleled importance. Scanning electron microscopy with its attendant x-ray analysis capability is the premier method of examining defects and attempting to identify their root cause.Defects are normally examined by cutting out a coupon sized portion of the autobody and viewing in an SEM at various angles.


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