Nonlinear active stress – Principal strain relation during pulsation of human iPS cell derived cardiomyocyte sheet

2021 ◽  
pp. 104199
Author(s):  
Hiroko Kurita ◽  
Mitsugu Todo
Keyword(s):  
Principal Strain ◽  
Ips Cell ◽  
Active Stress ◽  
Strain Relation

A topological approach to the strain-rate pattern of ice sheets

1993 ◽  
Vol 39 (131) ◽  
pp. 10-14 ◽  
Author(s):  
J. F. Nye
Keyword(s):  
Strain Rate ◽  
Ice Sheets ◽  
Ice Sheet ◽  
Point Of View ◽  
Principal Strain ◽  
Topological Approach ◽  
Contour Maps ◽  
Isotropic Point ◽  
Horizontal Strain

AbstractThe pattern of horizontal strain rate in an ice sheet is discussed from a topological point of view. In a circularly symmetric ice sheet, the isotropic point for strain rate at its centre is degenerate and structurally unstable. On perturbation the degenerate point splits into two elementary isotropic points, each of which has the lemon pattern for the trajectories of principal strain rate. Contour maps of principal strain-rate values are presented which show the details of the splitting.

The Impact of Coping Strategies on Situational Coping in Daily Life: An Ecological Momentary Assessment Study with the mHealth application TrackYourStress (Preprint)

2020 ◽  
Author(s):  
Teresa O'Rourke ◽  
Carsten Vogel ◽  
Dennis John ◽  
Rüdiger Pryss ◽  
Johannes Schobel ◽  
...  
Keyword(s):  
Social Support ◽  
Coping Strategies ◽  
Daily Life ◽  
Stress Coping ◽  
Positive Thinking ◽  
Active Stress ◽  
Situational Coping ◽  
Ecological Momentary ◽  
The Impact ◽  
Positive Effect

BACKGROUND It is necessary to cope with situations in daily life to prevent stress-related health consequences. However, coping strategies might differ in their impact on dealing with stressful situations in daily life. Moreover, the effect of coping strategies on situational coping might differ between women and men. OBJECTIVE The aim of this study was to investigate the impact of coping strategies on situational coping in everyday life situations and to investigate gender differences. METHODS An ecological momentary assessment study with the mobile health app TrackYourStress (TYS) was conducted with 113 participants. Coping strategies were measured at baseline with the coping scales Positive Thinking, Active Stress Coping, Social Support, Support in Faith, and Alcohol and Cigarette Consumption of the Stress and Coping Inventory (SCI). Situational coping was assessed by the question “How well can you cope with your momentary stress-level” (slider 0-100) in daily life over four weeks. Multilevel models were conducted to test the effects of the coping strategies on situational coping. Additionally, gender differences were evaluated. RESULTS Positive Thinking (P=.03) and Active Stress Coping (P=.04) had significant positive impacts on situational coping in the total sample. For women, only Social Support had a significant positive effect on situational coping (P=.046). For men, only Active Stress Coping had a significant positive effect on situational coping (P=.001). Women had higher scores on the SCI scale Social Support than men (P=.007). CONCLUSIONS These results suggest that different coping strategies could be more effective in daily life for women than for men, which should be considered in the development of interventions aimed at reducing stress consequences through coping. Interventions taking gender into consideration might lead to better coping-outcomes than generalized interventions.

Validation of three‐dimensional echocardiographic principal strain analysis for assessing left ventricular contractility: An animal study

2019 ◽  
Vol 46 (5) ◽  
pp. 2137-2144
Author(s):  
Sahmin Lee ◽  
Seunghyun Choi ◽  
Sehwan Kim ◽  
Yeongjin Jeong ◽  
Kyusup Lee ◽  
...  
Keyword(s):  
Animal Study ◽  
Three Dimensional ◽  
Strain Analysis ◽  
Left Ventricular ◽  
Principal Strain ◽  
Ventricular Contractility ◽  
Left Ventricular Contractility

scholarly journals A Splice Variant in SLC16A8 Gene Leads to Lactate Transport Deficit in Human iPS Cell-Derived Retinal Pigment Epithelial Cells

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 179
Author(s):  
Laurence Klipfel ◽  
Marie Cordonnier ◽  
Léa Thiébault ◽  
Emmanuelle Clérin ◽  
Frédéric Blond ◽  
...  
Keyword(s):  
Genome Wide Association Study ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Age Related Macular Degeneration ◽  
Lactate Transport ◽  
Ips Cell ◽  
Risk Alleles ◽  
Age Related ◽  
A Genome

Age-related macular degeneration (AMD) is a blinding disease for which most of the patients remain untreatable. Since the disease affects the macula at the center of the retina, a structure specific to the primate lineage, rodent models to study the pathophysiology of AMD and to develop therapies are very limited. Consequently, our understanding relies mostly on genetic studies highlighting risk alleles at many loci. We are studying the possible implication of a metabolic imbalance associated with risk alleles within the SLC16A8 gene that encodes for a retinal pigment epithelium (RPE)-specific lactate transporter MCT3 and its consequences for vision. As a first approach, we report here the deficit in transepithelial lactate transport of a rare SLC16A8 allele identified during a genome-wide association study. We produced induced pluripotent stem cells (iPSCs) from the unique patient in our cohort that carries two copies of this allele. After in vitro differentiation of the iPSCs into RPE cells and their characterization, we demonstrate that the rare allele results in the retention of intron 2 of the SLC16A8 gene leading to the absence of MCT3 protein. We show using a biochemical assay that these cells have a deficit in transepithelial lactate transport.

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