Genomic diversity of human papillomavirus type 6 from patients with condyloma acuminatum in Eastern China

Abstract Background Human papillomavirus (HPV) infection is involved in cervical cancer development, and hence understanding its prevalence and genotype distribution is important. However, there are few reports on the prevalence and genotype distribution of HPV in the city of Huzhou in China. Methods In this retrospective cross-sectional study, 11,506 women who visited Huzhou Maternity & Child Health Care Hospital between January 2018 and October 2019 were enrolled. The results of HPV genotyping and cytology tests were analyzed. Results The overall prevalence of HPV infection was 15.5%. The rate of high-risk (HR) HPV infection (13.5%) was higher than that of single low-risk (LR) HPV infection (2.0%) (p<0.05). The five most common HPV genotypes were HPV52 (3.3%), 16 (1.9%), 58 (1.7%), 53 (1.5%), and 81 (1.2%). The infection rate of HPV peaked in women aged 16–24 and women aged ≥55. The infection rate of HPV58 or HPV81 appeared as a single peak in women aged ≥55. The rates of HR-HPV and LR-HPV infection were higher in subjects with abnormal cytology (p<0.05). Conclusions HPV infection is high in Huzhou, and HPV53 and HPV81 are the prevalent genotypes. HPV infection rate is associated with age and cytology. Regional HPV surveillance is essential to optimize current HPV prevention and vaccine development.

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High-level of viral genomic diversity in cervical cancers: A Brazilian study on human papillomavirus type 16

Infection Genetics and Evolution ◽

10.1016/j.meegid.2015.07.002 ◽

2015 ◽

Vol 34 ◽

pp. 44-51 ◽

Cited By ~ 13

Author(s):

Cristina Mendes de Oliveira ◽

Ignacio G. Bravo ◽

Nathália Caroline Santiago e Souza ◽

Maria Luiza Nogueira Dias Genta ◽

José Humberto Tavares Guerreiro Fregnani ◽

...

Keyword(s):

Human Papillomavirus ◽

Genomic Diversity ◽

Cervical Cancers ◽

Human Papillomavirus Type 16 ◽

High Level

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Systematic literature review of risk factors for cervical cancer in the Chinese population

Women s Health ◽

10.1177/1745506518816599 ◽

2018 ◽

Vol 14 ◽

pp. 174550651881659 ◽

Cited By ~ 1

Author(s):

Xiao Li ◽

Shang Ying Hu ◽

Yunkun He ◽

Leyla Hernandez Donoso ◽

Kelly Qiao Qu ◽

...

Keyword(s):

Risk Factors ◽

Cervical Cancer ◽

Human Papillomavirus ◽

Literature Review ◽

Systematic Literature Review ◽

Chinese Population ◽

Eastern China ◽

Significant Risk ◽

China National Knowledge Infrastructure ◽

The Impact

Objectives: Human papillomavirus is the necessary cause of cervical cancer, in particular the human papillomavirus-16/18 strains, which have been detected in ~70% of all cervical cancer cases worldwide. This study aims to assess whether other cofactors, which might be specific for the Chinese population, are involved in the development of cervical cancer. These findings may support the future direction of cervical cancer prevention. Study Design: Systematic literature review. Methods: The following databases were searched: MEDLINE, MEDLINE-IN-PROCESS, EMBASE, China National Knowledge Infrastructure, Wanfang Data and Chongqing VIP Information. The target population were adolescents or adults from mainland China. All observational studies irrespective of intervention or comparator reporting risk factors for cervical cancer were included. The Newcastle-Ottawa Scale was used to assess study quality. The impact of each outcome was reported in numerical terms. Results: A total of 2,676 articles were screened. A total of 21 articles met the inclusion criteria. All studies were case-controlled designs mostly conducted in hospitals of South-Eastern China. A total of 18 studies reported lifestyle behaviours as significant influencing factors in the development of cervical cancer. Sexual behaviour, gestational factors, screening history, disease history and socio-demographics status were reported as significant risk factors for cervical cancer development. Conclusion: This review provides an up-to-date insight of current cervical cancer risk factors in China. Due to the heterogeneity of the results, further evaluation is recommended to determine the association of these risk factors to the overall risk of cervical cancer.

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Total excision and V-Y plasty technique in the anal area condyloma acuminatum

Indian Journal of Plastic Surgery ◽

10.1055/s-0039-1699231 ◽

2008 ◽

Vol 41 (01) ◽

pp. 67-69

Author(s):

Arif H. Demirel ◽

Ali U. Ongoren ◽

Ferruh BingÜl ◽

Nevzat Gulcelik

Keyword(s):

Human Papillomavirus ◽

Anal Canal ◽

Advancement Flap ◽

Condyloma Acuminatum ◽

Total Excision ◽

Perianal Region ◽

Perianal Area ◽

Flap Technique ◽

Venereal Transmission ◽

Anal Area

ABSTRACTCondyloma acuminatum is located in the perianal region, anal canal, vagina and the perineum. It is caused by human papillomavirus types 6 and 11. A 18 year-old man was admitted to the clinic because of a perianal mass. On examination of the patient′s perianal area and inside the anal canal, a mass was found, which was nearly 8 x 8 cm in size. We could not obtain any information about venereal transmission. The mass was totally excised and the defect was reconstructed with a bilateral V-Y advancement flap. This technique has been used for sacrococcygeal, ischial and other defects but rarely used for condyloma acuminatum. We think that total excision and the use of the V-Y advancement flap technique is safe and has low morbidity in the treatment of condyloma acuminatum.

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