Prevalence and genotype distribution of human papillomavirus infection in Huzhou City, eastern China, 2018–2019

2020 ◽  
Author(s):  
Yurong Zhu ◽  
Fuchu Qian ◽  
Weihua Zou ◽  
Xiaoyun Wu ◽  
Chunlin Liu ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Infection Rate ◽  
Vaccine Development ◽  
Eastern China ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Genotype Distribution ◽  
Care Hospital ◽  
Abnormal Cytology ◽  
Cross Sectional

Abstract Background Human papillomavirus (HPV) infection is involved in cervical cancer development, and hence understanding its prevalence and genotype distribution is important. However, there are few reports on the prevalence and genotype distribution of HPV in the city of Huzhou in China. Methods In this retrospective cross-sectional study, 11,506 women who visited Huzhou Maternity & Child Health Care Hospital between January 2018 and October 2019 were enrolled. The results of HPV genotyping and cytology tests were analyzed. Results The overall prevalence of HPV infection was 15.5%. The rate of high-risk (HR) HPV infection (13.5%) was higher than that of single low-risk (LR) HPV infection (2.0%) (p<0.05). The five most common HPV genotypes were HPV52 (3.3%), 16 (1.9%), 58 (1.7%), 53 (1.5%), and 81 (1.2%). The infection rate of HPV peaked in women aged 16–24 and women aged ≥55. The infection rate of HPV58 or HPV81 appeared as a single peak in women aged ≥55. The rates of HR-HPV and LR-HPV infection were higher in subjects with abnormal cytology (p<0.05). Conclusions HPV infection is high in Huzhou, and HPV53 and HPV81 are the prevalent genotypes. HPV infection rate is associated with age and cytology. Regional HPV surveillance is essential to optimize current HPV prevention and vaccine development.

scholarly journals Prevalence and genotypes of anal human papillomavirus infection among HIV-positive vs. HIV-negative men in Taizhou, China

2019 ◽  
Vol 147 ◽  
Author(s):  
X. Liu ◽  
H. Lin ◽  
X. Chen ◽  
W. Shen ◽  
X. Ye ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Quadrivalent Vaccine ◽  
Hiv Positive ◽  
Genotype Distribution ◽  
Bisexual Men ◽  
Cross Sectional ◽  
Control And Prevention ◽  
Hiv Negative

AbstractThis study aims to investigate the prevalence and genotype distribution of anal human papillomavirus (HPV) infection among men with different sexual orientations with or without human immunodeficiency virus (HIV) in China. A cross-sectional study was conducted during 2016–2017 in Taizhou City, Zhejiang Province. Convenient sampling was used to recruit male participants from HIV voluntary counselling and testing clinics and Center for Disease Control and Prevention. A face-to-face questionnaire interview was administered and an anal-canal swab was collected for HPV genotyping. A total of 160 HIV-positive and 113 HIV-negative men participated in the study. The prevalence of any type HPV was 30.6% for heterosexual men, 74.1% for homosexual and 63.6% for bisexual men among HIV-positive participants, while the prevalence was 8.3%, 29.2% and 23.8% respectively among HIV-negatives. The most prevalent genotypes were HPV-58 (16.9%), HPV-6 (15.6%) and HPV-11 (15.0%) among HIV-positive men, and were HPV-16 (4.4%), HPV-52 (4.4%) and HPV-6 (3.5%) among HIV-negative men. Having ever had haemorrhoids and having ever seen blood on tissue after defaecation was associated with HPV infection. One-fourth of the HPV infections in this study population can be covered by the quadrivalent vaccine in market. The highly prevalent anal HPV infection among men especially HIV-infected men calls for close observation and further investigation for anal cancer prevention.

scholarly journals Prevalence and genotype distribution of human papilloma virus in cervical samples of young married women: a hospital based prospective cross-sectional study

2021 ◽  
Vol 10 (11) ◽  
pp. 4113
Author(s):  
Madhuri N. Bagde ◽  
Nilajkumar D. Bagde ◽  
Pugazhentan Thangaraju ◽  
Sanjay Negi ◽  
Pooja Deshmukh
Keyword(s):  
High Risk ◽  
Degrees Of Freedom ◽  
Tertiary Care ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Married Women ◽  
Genotype Distribution ◽  
Care Hospital ◽  
Cross Sectional ◽  
Significant Difference

Background: The aim of the study was to determine the prevalence and genotypes of human papillomavirus (HPV) infection in the cervical samples of young married women at a tertiary care hospital in Chhattisgarh. A prospective cross-sectional observational study was performed in married women, aged 18 to 30 years.Methods: Relevant history was noted and cervical samples were collected and tested for HPV deoxyribonucleic acid (DNA) by polymerase chain reaction (PCR). Data was compiled to calculate the prevalence of HPV and the genotypic distribution.Results: The overall prevalence of HPV in this study was 22.73% and that of type 16 and 18 either alone or in combination with other subtypes was 17.26%. They were the commonest subtypes. HPV positivity was inversely related to education levels (Chi square, p=0.05). There was a significant difference in parity of women testing positive for HPV versus those negative for HPV (one tailed Pr (t<t)=0.03, 95% CI=1.445 to 1,865 at 108 degrees of freedom). No difference was observed between education and socio economic levels of positive versus negative women. Type 16 and 18 accounted for 76% of all HPV subtypes detected.Conclusions: The prevalence of HPV infection is high in Indian women. The high risk oncogenic types are the commonest subtypes. There is an urgent need to screen for the presence of high risk HPV infections in younger women so that they may be followed up more closely to prevent cervical cancers.

scholarly journals Human papillomavirus vaccination coverage among working women

2021 ◽  
Vol 6 (4) ◽  
pp. 714-722
Author(s):  
Sajeda Khatun ◽  
Ashees Kumar Saha ◽  
Irtiza Ahmed Chowdhury ◽  
Arifa Sultana ◽  
Mst Wazeda Begum ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Vaccination Coverage ◽  
Hpv Vaccination ◽  
Working Women ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
P Value ◽  
Human Papillomavirus Vaccination ◽  
Cross Sectional

Human papillomavirus (HPV) infection is one of the causes of cervical cancer which is preventable. The study was a cross-sectional study with the objective was to determine the Human papillomavirus (HPV) vaccination coverage among working women. A total 236 educated working women were selected purposively from different working places in Dhaka city. A pretested semi- structured questionnaire was used for data collection. The knowledge was assessed by using modified Blooms cut off points which was developed with cervical cancer and vaccine knowledge related questions. The study result revealed that among 236 working women 71.2% knew about the risk factor of cervical cancer. It was found that 92.8% knew about the way of prevention of cervical cancer respectively. The overall knowledge on cervical cancer and vaccine was found to be having good knowledge 21.2%, satisfactory knowledge 41.9% and poor knowledge 36.9%. Out of the total working women only 5.1% had HPV vaccination coverage. Reason behind non vaccinations, 50% mentioned had no knowledge about vaccine, 35.3% mentioned can’t decide and 8.9% mentioned high cost of vaccine. Significant association has been observed in between vaccination coverage with over all knowledge of cervical cancer (p value .04). It may be concluded that HPV vaccination coverage is very low which needs awareness program on this issues through mass media, educational session, counseling and so on to reduce human papillomavirus associated cancers as well as economic burden. Asian J. Med. Biol. Res. December 2020, 6(4): 714-722

Carriage of high-risk human papillomavirus infection in male subjects in Ouagadougou, Burkina Faso

2019 ◽  
Author(s):  
Sya Forazoun Bienvenue Tamini ◽  
Theodora Mahoukèdè Zohoncon ◽  
Serge Theophile Soubeiga ◽  
Florencia Wendkuuni Djigma ◽  
Ina Marie Angele Traore ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Burkina Faso ◽  
Public Health Problem ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Multiple Infections ◽  
Cross Sectional ◽  
High Risk Hpv ◽  
Male Subjects

Abstract Background Human papillomavirus (HPV) infection is a public health problem in Africa because of its frequency and its various consequences in both men and women. In Burkina Faso, there is little data on the carriage of HPV infection in male subjects. This study aimed to determine the carriage of HPV infection in male subjects in Ouagadougou, Burkina Faso.Methods This was a cross-sectional study conducted from December 2015 to September 2016. During this study period, a total of 124 male subjects who gave informed consent were recruited as part of a fertility assessment. Semen samples were analyzed by Real- Time PCR using Real TM Quant High Risk Screen HPV kit to detect 14 high-risk HPV genotypes. The Chi square test was used for comparisons.Results Of the 124 male subjects, 22 were positive for at least one high-risk HPV, with a prevalence of 17.7%. HPV 56 was the most represented genotype with a frequency of 20%, followed by HPV 39 (11%) and HPV 68 (11%), HPV 16 (8%). The genotypes HPV 18, HPV33, HPV35, HPV51 and HPV52 also had the same frequency of 6% each and the HPV 31, 45, 59 and 66 had the same frequency of 3% each. Of the 22 positive cases, 10 were multiple infections. Spermocytogram of patients showed at least one abnormality in 87.9% of cases. Necrozoospermia and oligozoospermia were the most abnormalities observed with 42% and 40% respectively followed by asthenospermia (18%); teratozoospermia (16%) and azoospermia (14%).Conclusion This study showed that like women, men are infected by HPV with a relatively high prevalence. In addition, the predominant genotypes in the male subjects of this study are not those targeted by the HPV vaccines available in our countries. Hence the need to reinforce the strategies for controlling HPV infection and HPV prophylactic vaccination for young boys.

Prevalence and genotype distribution of HPV infection among 214,715 women from Southern China, 2012-2018: baseline measures prior to mass HPV vaccination

2020 ◽  
Author(s):  
Lipei Luo ◽  
Ping He ◽  
qiaotu liu ◽  
Yanghua jiang ◽  
Yang-nan Zhang ◽  
...  
Keyword(s):  
Young Women ◽  
Southern China ◽  
Cervical Screening ◽  
Hpv Vaccination ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Genotype Distribution ◽  
Cross Sectional ◽  
Hpv Prevalence ◽  
Hpv Genotypes

Abstract Background: The epidemiology on the human papillomavirus (HPV) among females in Southern China is not well-established. Baseline data on the prevalence of HPV infection in China prior to mass prophylactic HPV vaccination would be useful. Thus, this study aimed to determine the type-specific HPV prevalence and distribution among females from Southern China prior to mass HPV vaccination. Methods: A retrospective cross-sectional study employing 214,715 women attending ChenZhou NO.1 People’s Hospital for cervical screening during 2012-2018 was conducted prior to widespread HPV vaccination. HPV genotype was detected using nucleic acid molecular diversion hybridization tests. The overall prevalence, age-specific prevalence, type distribution, and annual trend were analyzed. Results: The overall HPV prevalence was 18.71% (95% confidence interval [CI], 18.55%-18.88%) among Southern China females. During 2012–2018, the prevalence of HPV infection showed a downward tendency, from 21.63% (95% CI, 21.07%-22.20%) in 2012 to 18.75% (95% CI, 18.35%-19.16%) in 2018. Age-specific HPV distribution displayed a peak at young women aged less than 21 years (33.11%, 95% CI, 31.13%-35.15%), 20.07% (95% CI, 19.70%-20.44%) among women aged 21-30 years, 17.29% (95% CI, 17.01%-17.57%) among women aged 31-40 years, 17.23% (95% CI, 16.95%-17.51%) among women aged 41-50 years, 21.65% (95% CI, 21.11%-22.20%) among women aged 51-60 years, and 25.95% (95% CI, 24.86%-27.07%) among women aged over 60 years. Of the 21 subtypes identified, the most three prevalent high-risk HPV (HR-HPV) genotypes were HPV52 (5.12%; 95% CI, 21.11%-22.20%), -16 (2.96%; 95% CI, 2.89%-3.03%), and -58 (2.51%; 95% CI, 2.44%-2.58%); the predominant low-risk HPV (LR-HPV) genotypes were HPV81 (1.86%; 95%CI, 1.80%-1.92%) and -6 (0.69%; 95% CI, 0.66%-0.73%) respectively. Incidence of HR-HPV only, LR-HPV only and mixed LR- and HR-HPV were 15.17%, 2.07% and 1.47% respectively. Besides, single HPV infection accounted for 77.30% of all positive cases in this study.Conclusions: This study highlights 1) a high prevalence of HPV infection among females with a decreasing tendency towards 2012-2018, especially for young women under the age of 21 prior to mass HPV vaccination; 2) HPV52, -16 and -58 were the predominant HPV genotypes, suggesting potential use of HPV vaccine covering these HPV genotypes in Southern China.

Age factor and implication of human papillomavirus type-specific prevalence in women with normal cervical cytology

2011 ◽  
Vol 140 (3) ◽  
pp. 466-473 ◽  
Author(s):  
C. H. LAI ◽  
A. CHAO ◽  
C. J. CHANG ◽  
C. C. HUANG ◽  
L. C. WANG ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hormone Replacement ◽  
Menopausal Status ◽  
Hpv Infection ◽  
Population Based ◽  
Cervical Cytology ◽  
Genotype Distribution ◽  
Abnormal Cytology ◽  
Normal Cytology ◽  
Normal Cervical Cytology

SUMMARYThe prevalence and genotype distribution of human papillomavirus (HPV) infection in women with normal cervical cytology varies widely according to the population studied. Two non-overlapping population-based cohort studies of women aged ⩾30 years for the periods 2008–2009 (n=5026) and 2004–2005 (n=10 014) were analysed. The prevalence rate of HPV was 11·0% (95% CI 10·5–11·6). HPV infection was significantly associated with age, menopausal status, and inversely associated with hormone replacement therapy. There was an increasing trend of α3/α15, α5/α6, and multiple HPV infections with increasing age. The five most common types were HPV52, 18, 53, 58 and 70, while HPV16, 31, 33 ranked 21st, 25th, and 16th, respectively, in the merged cohort with normal cytology (n=14 724). HPV16, 31, and 33 were significantly associated with abnormal cytology, which could have resulted in their rarity in the total merged cohort (n=15 040).

scholarly journals HPV Infection in a Cohort of HIV-Positive Men and Women: Prevalence of Oncogenic Genotypes and Predictors of Mucosal Damage at Genital and Oral Sites

2013 ◽  
Vol 2013 ◽  
pp. 1-8
Author(s):  
Giulia Marchetti ◽  
Laura Comi ◽  
Teresa Bini ◽  
Marco Rovati ◽  
Francesca Bai ◽  
...  
Keyword(s):  
Mucosal Damage ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Low Grade ◽  
Abnormal Cytology ◽  
Cross Sectional ◽  
Squamous Cells ◽  
Hpv Prevalence ◽  
Oral Hpv

The aim of this study was to assess the prevalence of HPV infection and determinants of abnormal cytology in HIV-positive patients. In a cross-sectional study, patients of both sexes, asymptomatic for HPV, underwent anorectal (men)/cervical (women) and oral swabs. Cytology and HPV-PCR detection/genotyping (high- and low-risk genotypes, HR-LR/HPV) were performed. A total of 20% of the 277 enrolled patients showed oral HPV, with no atypical cytology; in men, anal HPV prevalence was 81% with 64% HR genotypes. In women, cervical HPV prevalence was 58% with 37% HR-HPV. The most frequent genotypes were HPV-16 and HPV-18; 37% of men and 20% of women harbored multiple genotypes. Also, 47% of men showed anal squamous intraepithelial lesions (SILs); 6% had high- and 35% low-grade SILs (HSILs/LSILs); 5% had atypical squamous cells of undetermined significance (ASC-US). HR-HPV was independently associated with anal-SIL in men (P=0.039). Moreover, 37% of women showed cervical SIL: 14 ASC-US, 15 LSILs, 4 HSILs, and 1 in situ cancer. The presence of both LR and HR-HPV in women was independently associated with SIL (P=0.003 and P=0.0001). HR-HPV and atypical cytology were frequently identified in our cohort. HPV screening should be mandatory in HIV-infected subjects, and vaccine programs for HPV-negative patients should be implemented.

Low rate of oral human papillomavirus (HPV) infection in women screened for cervical HPV infection in Southern Italy: A cross-sectional study of 140 immunocompetent subjects

2009 ◽  
Vol 81 (8) ◽  
pp. 1438-1443 ◽  
Author(s):  
Nicoletta Termine ◽  
Lucia Giovannelli ◽  
Domenica Matranga ◽  
Antonio Perino ◽  
Vera Panzarella ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Southern Italy ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Low Rate

scholarly journals Awareness and screening practices of cervical cancer among nursing staff working in tertiary care hospital

2017 ◽  
Vol 4 (10) ◽  
pp. 3590
Author(s):  
Swati M. Mahajan ◽  
Vijaykumar S. Jadhav ◽  
Anwaya R. Magare ◽  
Sangita A. Adchitre ◽  
Sobha B. Salve
Keyword(s):  
Cervical Cancer ◽  
Nursing Staff ◽  
Early Stage ◽  
Tertiary Care ◽  
Female Genital Tract ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Screening Process ◽  
Cross Sectional

Background: In India there are an estimated of 1,32,000 new cases and 74,000 deaths each year of cervical cancer. Out of all the female genital tract cancers, it is the only pre­ventable cancer if detected at its early stages. More than one fifth of all new cases are diagnosed in India due to a lack of screening that allows detection of precancerous and early stage cervical cancer. Staff nurses if trained properly, can make aware and screen all the women coming to detect suspicious cases. The present study was carried to assess knowledge regarding cervical cancer, screening procedures and attitude and practices regarding prevention and screening of cervical cancer among nursing staff.Methods: A cross-sectional study was carried out among the nursing staff between March to June 2016. A total of 215 nursing staff was enrolled in the study.Results: Majority 75 (34.88%) of the participants were from 41-50 years of age and 147 (67.90%) were married. The majority of the participants received information about cervical cancer and screening from hospital 135 (71.05%) and 40 (21.05%) from the newspaper. Majority of females 68 (35.78%) said HPV infection as major risk factor for cervical cancer. Majority of the females 125 (65.78%) mentioned that discharge p/v is the main symptom. Majority of the participants 66 (38.82%) replied that married Women and sexually active 54 (31.76%) women must be screened.Conclusions: It can be concluded that presently the knowledge and understanding of cervical cancer, as well as its screening process, is satisfactory, but there is a vast scope for improvement. 

Sign in / Sign up

Export Citation Format

Share Document