Molecular basis of the evolution of drug resistance: potential role of the transient state during infection/drug treatment

2004 ◽  
Vol 63 (1) ◽  
pp. 71-72 ◽  
Author(s):  
Subburaj Kannan
Keyword(s):  
Drug Resistance ◽  
Drug Treatment ◽  
Molecular Basis ◽  
Potential Role ◽  
Transient State

Molecular Pathogenesis of Sporadic Melanoma and Melanoma-Initiating Cells

2010 ◽  
Vol 134 (12) ◽  
pp. 1740-1749
Author(s):  
Yunyi Kong ◽  
Suresh M. Kumar ◽  
Xiaowei Xu
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Biology ◽  
Molecular Basis ◽  
Potential Role ◽  
Genetic Alterations ◽  
Stem Cell Biology ◽  
Prevalent Disease

Abstract Recent advances in molecular genetics and cancer stem cell biology have shed some light on the molecular basis of melanomagenesis. In this review, we will focus on major genetic alterations in the melanoma, particularly pathways involved in cell proliferation, apoptosis, and tumor suppression. The potential role of melanoma-initiating cells during melanomagenesis and progression will also be discussed. Understanding pathogenesis of melanoma may uncover new diagnostic clues and therapeutic targets for this increasingly prevalent disease.

scholarly journals Current Landscape and the Potential Role of Hypoxia-Inducible Factors and Selenium in Clear Cell Renal Cell Carcinoma Treatment

2018 ◽  
Vol 19 (12) ◽  
pp. 3834 ◽  
Author(s):  
Rohan Garje ◽  
Josiah An ◽  
Kevin Sanchez ◽  
Austin Greco ◽  
Jeffrey Stolwijk ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Drug Resistance ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Potential Role ◽  
Clear Cell ◽  
Hypoxia Inducible Factors ◽  
Angiogenic Growth Factors ◽  
Cell Renal Cell Carcinoma

In the last two decades, the discovery of various pathways involved in renal cell carcinoma (RCC) has led to the development of biologically-driven targeted therapies. Hypoxia-inducible factors (HIFs), angiogenic growth factors, von Hippel–Lindau (VHL) gene mutations, and oncogenic microRNAs (miRNAs) play essential roles in the pathogenesis and drug resistance of clear cell renal cell carcinoma. These insights have led to the development of vascular endothelial growth factor (VEGF) inhibitors, Mechanistic target of rapamycin (mTOR) inhibitors, and immunotherapeutic agents, which have significantly improved the outcomes of patients with advanced RCC. HIF inhibitors will be a valuable asset in the growing therapeutic armamentarium of RCC. Various histone deacetylase (HDAC) inhibitors, selenium, and agents like PT2385 and PT2977 are being explored in various clinical trials as potential HIF inhibitors, to ameliorate the outcomes of RCC patients. In this article, we will review the current treatment options and highlight the potential role of selenium in the modulation of drug resistance biomarkers expressed in clear cell RCC (ccRCC) tumors.

Confusion

2020 ◽  
pp. 6454-6456
Author(s):  
Bart Sheehan ◽  
Thomas Jackson
Keyword(s):  
Older People ◽  
Potential Role ◽  
Transient State ◽  
Vascular Event ◽  
Medical Patients ◽  
Common Presentation

Confusion is a very common presentation in medical patients, especially in older people. It may, but does not always, indicate dementia. Delirium describes a typically brief, fluctuating, and transient state of confusion, which requires a vigorous and urgent hunt for the cause or causes. This is often, but not always, an infection or vascular event. The potential role of prescribed drugs in causing confusion should not be forgotten, and other causes of apparent confusion include depression. Making the diagnosis might take time, and in the meantime it is important to ensure that the physical and nursing arrangements for care keep the patient safe from harm.

scholarly journals Potential role of exosome-associated microRNA panels and in vivo environment to predict drug resistance for patients with multiple myeloma

Oncotarget ◽  
2016 ◽  
Vol 7 (21) ◽  
pp. 30876-30891 ◽  
Author(s):  
Li Zhang ◽  
Ling Pan ◽  
Bing Xiang ◽  
Huanling Zhu ◽  
Yu Wu ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Drug Resistance ◽  
Potential Role

Molecular Basis of Posttransplant Squamous Cell Carcinoma: The Potential Role of Cyclosporine A in Carcinogenesis

2006 ◽  
Vol 116 (5) ◽  
pp. 762-769 ◽  
Author(s):  
Jeremy Tiu ◽  
Hongli Li ◽  
Christopher Rassekh ◽  
Paul van der Sloot ◽  
Rodney Kovach ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cyclosporine A ◽  
Molecular Basis ◽  
Potential Role
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