Conflicts of interest in medical science: peer usage, peer review and `CoI consultancy'

2004 ◽  
Vol 63 (2) ◽  
pp. 181-186 ◽  
Author(s):  
Bruce G Charlton
F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 805
Author(s):  
Greg Irving ◽  
John Holden

At the request of the authors Greg Irving and John Holden, the article titled “How blockchain-timestamped protocols could improve the trustworthiness of medical science” has been retracted from F1000Research. The authors have taken this decision after considering the methodological concerns raised by a peer reviewer during the post-publication open peer review process. As the methodology has been deemed to be unreliable, the article is now retracted. This applies to all three versions of the article: Irving G and Holden J. How blockchain-timestamped protocols could improve the trustworthiness of medical science [version 1; referees: 2 approved]. F1000Research 2016, 5:222 (doi: 10.12688/f1000research.8114.1) Irving G and Holden J. How blockchain-timestamped protocols could improve the trustworthiness of medical science [version 2; referees: 3 approved]. F1000Research 2016, 5:222 (doi: 10.12688/f1000research.8114.2) Irving G and Holden J. How blockchain-timestamped protocols could improve the trustworthiness of medical science [version 3; referees: 3 approved, 1 not approved]. F1000Research 2017, 5:222 (doi: 10.12688/f1000research.8114.3).


Author(s):  
Geoffrey Boyd

At its core, academic knowledge production is predicated on Western notions of knowledge historically grounded in a Euro-American, White, male worldview. As a component of academic knowledge production, scholarly publishing shares the same basis of Whiteness. It excludes knowledge that doesn’t conform to White, Western notions of knowledge, forces conformity to (and therefore reinforcement of) a Western standard of writing/knowledge, and leads to a reverence of peer-reviewed literature as the only sound source of knowledge. As a tool of scholarly publishing and the editorial process, blind peer review, though perhaps well-intentioned, is fraught with problems, especially for BIPOC researchers and writers, because it fails in its intended purpose to drastically reduce or eliminate bias and racism in the peer review and editorial processes; shields peer reviewers and editors against accusations of bias, racism, or conflicts of interest; and robs BIPOC, and particularly Indigenous, writers and researchers from having the opportunity to develop relationships with those that are reviewing and publishing their work.


2015 ◽  
Vol 97 (7) ◽  
pp. 487-489 ◽  
Author(s):  
PJ Benson

‘Medical science can only flourish in a free society and dies under totalitarian repression.’ 1 Peer review post-publication is relatively easy to define: when the world decides the importance of publication. Peer review pre-publication is what the scientific community frequently means when using the term ‘peer review’. But what it is it? Few will agree on an exact definition; generally speaking, it refers to an independent, third party scrutiny of a manuscript by scientific experts (called peers) who advise on its suitability for publication. Peer review is expensive; although reviewers are unpaid, the cost in time is enormous and it is slow. There is often little agreement among reviewers about whether an article should be published and peer review can be a lottery. Often referred to as a quality assurance process, there are many examples of when peer review failed. Many will be aware of Woo-Suk Hwang’s shocking stem cell research misconduct at Seoul National University. 2 Science famously published two breakthrough articles that were found subsequently to be completely fabricated and this happened in spite of peer review. Science is not unique in making this error. However, love it or hate it, peer review, for the present time at least, is here to stay. In this article, Philippa Benson, Managing Editor of Science Advances (the first open access journal of the American Association for the Advancement of Science), discusses the merits of peer review. Dr Benson has extensive experience in the publishing world and was Executive Director of PJB Consulting, a not-for-profit organisation supporting clients on issues related to converting to full electronic publishing workflows as well as challenges working with international authors and publishers. Her clients included the Public Library of Science journals, the American Society for Nutrition and the de Beaumont Foundation. She recently co-authored a book, What Editors Want: An Author’s Guide to Scientific Journal Publishing (University of Chicago Press), which helps readers understand and navigate the publishing process in high impact science and technical journals. Her master’s and doctorate degrees are from Carnegie Mellon University. JYOTI SHAH Commissioning Editor References 1. Eaton KK . Editorial: when is a peer review journal not a peer review journal? J Nutr Environ Med 1997 ; 7 : 139 – 144 . 2. van der Heyden MA , van de Ven T , Opthof T . Fraud and misconduct in science: the stem cell seduction . Neth Heart J 2009 ; 17 : 25 – 29 .


2021 ◽  
Vol 2 (4) ◽  
pp. 215-221
Author(s):  
Jaime A. Teixeira da Silva

Editors play a central role and form an essential link in the publication process. Consequently, they hold considerable influence as to how the literature is molded, and what eventually gets published. In addition to their standard editorial responsibilities, holding that amount of power, editors have extremely high responsibilities to declare any conflicts of interest (COIs) internal to, and external to, the peer review process, particularly those involving personal relationships and networks. This is because they also exist in the peer community, can be high-profile public figures, and form a very unique and restricted – in terms of size, membership and exclusivity – set of individuals. Consequently, editors need to declare their COIs openly, transparently, and publicly on their editor board profiles, and as part of their curriculum vitae. Without such declarations, the greater risk is that editors might have unregulated freedom to enforce their own individual or group biases, through hidden relationships and networks, including the possibility of hiding instances of favoritism, cronyism and nepotism. In the worst-case scenario, this might reflect editorial corruption. Hidden COIs in authors, which tend to be the focus of the academic publishing establishment, including in codes of conduct and ethical guidelines such as those by COPE and the ICMJE, tend to down-play editorial COIs, or restrict them to scrutiny during the peer review process. This opinion piece examines whether there is a systemic problem with under-reported editorial COIs, particularly personal and non-financial COIs, that extend beyond the peer review process and their editorial positions. Greater awareness, debate, and education of this issue are needed.


2020 ◽  
Vol 4 (1) ◽  
pp. 26-36
Author(s):  
Svitlana Fiialka ◽  
Olga Trishchuk ◽  
Nadija Figol

The purpose of the paper is to summarize the organizational and ethical aspects, problems and prospects of peer reviewing. To do this, from September 2019 to January 2020, a survey of Ukrainian scientists registered in Facebook groups “Ukrainian Scientific Journals”, “Ukrainian Scientists Worldwide”, “Pseudoscience News in Ukraine”, “Higher Education and Science of Ukraine: Decay or Blossom?” and others was conducted. In total, 390 researchers from different disciplines participated in the survey. The results of the survey are following: 8.7% of respondents prefer open peer review, 43.1% – single-blind, 37.7% – double blind, 9.2% – triple blind, 1.3% used to sign a review prepared by the author. 75.6% of respondents had conflicts of interest during peer reviewing. 8.2 % of reviewers never reject articles regardless of their quality. Because usually only editors and authors see reviews, it can lead to the following issues: reviewers can be rude or biased; authors may not adequately respond to grounded criticism; editors may disregard the position of the author or reviewer, and journals may charge for publishing articles without proper peer review.


Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 5412-5412
Author(s):  
Xinzhen Cai ◽  
Jun Ni ◽  
Wei Wu ◽  
Qingqing Shi ◽  
Zou Li ◽  
...  

Abstract Introduction To preliminary study the repair effect of umbilical cordmesenchymal stem cells (UC-MSCs) homing on local and systemic inflammatory microenvironment and immune inflammatory thrombophilia states of the CIA rata by observing the distribution of the UC-MSCs in the CIA rate and the influence of the UC-MSCs on the expression of the inflammatory cytokines IL-10, TNF-α IL-6, IFN-γ and the thrombosis indicators TF, VWF, DD, FIB's. Methods The clean grade, female, 5-week-old SD rats were randomly divided into a control (C) group, model (M) group, UC-MSCs treatment (SU) group, adding AMD3100 to labled UC-MSCs therapy (ASU) group. Except for control group, the other rats were induced as CIA rats model. Treatment group were injected UC-MSCs suspension by tail vein. The rats were sacrificed in the first, the third and the fifth week after transplantation. HE staining was used to observe the pathological changes of joint tissues. The distribution of UC-MSCs in the joint tissue was detected by FISH. ELISA assay was used to observe the expression of inflammation and thrombosis indicators in peripheral blood. The expression of inflammatory factors in the joint tissue were detected by western blot. Results: 1. One week after injection, the expression of SDF-1 in the injuried joint of the group SU was significantly increased compared with the control group, at the same time, the large number of UC-MSCs occured in injured sites. While, adding AMD3100 to labled UC-MSCs were not expressed in the joint tissue. The expression of SDF-1 in the labled UC-MSCs treating group decreased over time, and the number of UC-MSCs reduced in the inflammatory joints. 2. After given UC-MSCs treatment, the levels of pro-inflammatory cytokines IL-6, TNF-α, IFN-γ in the knee and serum were conspicuously reduced compared with the group M since the first week. While the level of anti-inflammatory cytokine IL-10 was increased (p <0.05). After adding AMD3100, the expression of above indicators in the group ASU showed no significant difference compared to the group C. 3. After given UC-MSCs treatment, the levels of TF in serum and DD, FIB, VWF in plasma were conspicuously reduced compared to the group M since the first week (p <0.05). The expression of the above indicators in the group ASU showed no significant difference compared to the group C. Conclusion: 1. UC-MSCs homing to the injured joint tissue is influnced by the local inflammation environment, which is an important way to play its role of immune regulation to improve the immune inflammatory thrombophilia state in CIA rsts. 2. SDF-1/CXCR4 axis is important to the UC-MSCs homing, the antagonist AMD3100 can suppress the UC-MSC homing to the injured site. Funded by Jiangsu Provincial Special Program of Medical Science (BL2012005) Disclosures No relevant conflicts of interest to declare.


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