Background:
Present malignant cancer medicines has the advancement of magnetic nanoparticles as delivery carriers to
magnetically accumulate anticancer medication in malignant growth tissue.
Aim:
In the present investigation, a silica nanoparticles (MSNs) stacked with hydroxyurea were combined and was optimized for dependent
and independent variables.
Method:
In this study, microporous silica nanoparticle stacked with neoplastic medication had been prepared through emulsification
followed with solvent evaporation method. Prepared MSNs were optimized for dependent and independent variables. Different formulations
were prepared with varying ratio of polymer, lipid and surfactant which affects drug release and kinetics of drug release pattern. The obtained
MSNs were identified by FTIR, SEM, drug entrapment, in-vitro drug release, drug release kinetics study, stability testing in order to
investigate the nanoparticle characteristics.
Results:
The percentage drug entrapment of the drug for the formulations F1, F2, F3, was found to be 27.78%, 65.52% and 48.26%. The
average particle size for F2 formulation was found to be 520 nm through SEM. The cumulative drug release for the formulations F1, F2, F3
was found to be 64.17%, 71.82% and 32.68%. The formulations were found to be stable which gives controlled drug delivery for 6 hours.
Conclusion:
From the stability studies data it can be culminated that formulations are most stable when stored at lower temperature or in
refrigerator i.e. 5˚C ± 3˚C. It can be concluded that MSN’s loaded with hydroxyurea is a promising approach towards the management of
cancer due to its sustained release and less side effects.
