Solid state and solubility study of a potential anticancer drug-drug molecular salt of diclofenac and metformin

2021 ◽  
Vol 1234 ◽  
pp. 130166
Author(s):  
Wen-Quan Feng ◽  
Ling-Yang Wang ◽  
Jie Gao ◽  
Ming-Yu Zhao ◽  
Yan-Tuan Li ◽  
...  
Keyword(s):  
Solid State ◽  
Anticancer Drug ◽  
Solubility Study ◽  
Molecular Salt

Tosylate salts of the anticancer drug lapatinib

2013 ◽  
Vol 69 (12) ◽  
pp. 1516-1523 ◽  
Author(s):  
K. Ravikumar ◽  
B. Sridhar ◽  
Jagadeesh Babu Nanubolu ◽  
A. K. S. Bhujanga Rao ◽  
R. Jyothiprasad
Keyword(s):  
Solid State ◽  
Hydrogen Bonds ◽  
Physicochemical Properties ◽  
Anticancer Drug ◽  
Ring System ◽  
Nonbonded Interactions ◽  
One Dimensional ◽  
Drug Products ◽  
Ring Motif

Two tosylate salts of an anticancer drug lapatinib,viz. a monotosylate [systematic name: ({5-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)quinazolin-6-yl]furan-2-yl}methyl)[2-(methylsulfonyl)ethyl]azanium 4-methylbenzenesulfonate], C29H27ClFN4O4S+·C7H7O3S−, (I), and a ditosylate [systematic name: 4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)-6-]5-({[2-(methylsulfonyl)ethyl]azaniumyl}methyl)furan-2-yl[quinazolin-1-ium bis(4-methylbenzenesulfonate)], C29H28ClFN4O4S2+·2C7H7O3S−, (II), were obtained during crystallization attempts for polymorphism. In both structures, the lapatinib cation is in a distorted U-like conformation and the tosylate anion is clamped between the aniline N atom and methylamine N atom through N—H...O hydrogen bonds, forming anR22(15) ring motif. The 4-anilinoquinazoline ring system is essentially planar in (I), while it is twisted in (II), controlled by an intramolecular C—H...N interaction. In (I), alternating cations and anions are linked by N—H...O hydrogen bonds intoC22(6) chains. These chains are linked by cations in a helical manner. The presence of the additional tosylate anion in (II) results in the formation of one-dimensional tapes of fused hydrogen-bonded rings through N—H...O and C—H...O interactions. These studies augment our understanding of the role of nonbonded interactions in the solid state, which is useful for correlation to the physicochemical properties of drug products.

Interaction of a gold(i) dicarbene anticancer drug with human telomeric DNA G-quadruplex: solution and computationally aided X-ray diffraction analysis

2018 ◽  
Vol 47 (45) ◽  
pp. 16132-16138 ◽  
Author(s):  
Federica Guarra ◽  
Tiziano Marzo ◽  
Marta Ferraroni ◽  
Francesco Papi ◽  
Carla Bazzicalupi ◽  
...  
Keyword(s):  
Solid State ◽  
Diffraction Analysis ◽  
Anticancer Drug ◽  
Clear Picture ◽  
X Ray Diffraction ◽  
Telomeric Dna ◽  
State Data ◽  
X Ray ◽  
Anticancer Properties ◽  
G Quadruplex

Solution and solid-state data give a quite clear picture for a bis carbene gold(i) complex having perspective anticancer properties.

Crystal Structure Determination of Dimenhydrinate after More than 60 Years: Solving Salt–Cocrystal Ambiguity via Solid-State Characterizations and Solubility Study

2016 ◽  
Vol 16 (9) ◽  
pp. 5223-5229 ◽  
Author(s):  
Okky Dwichandra Putra ◽  
Tomomi Yoshida ◽  
Daiki Umeda ◽  
Kenjirou Higashi ◽  
Hidehiro Uekusa ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Solid State ◽  
Structure Determination ◽  
Crystal Structure Determination ◽  
Solubility Study

Drug–Drug Molecular Salt Hydrate of an Anticancer Drug Gefitinib and a Loop Diuretic Drug Furosemide: An Alternative for Multidrug Treatment

2015 ◽  
Vol 104 (12) ◽  
pp. 4207-4216 ◽  
Author(s):  
Shridhar H. Thorat ◽  
Sanjay Kumar Sahu ◽  
Manjusha V. Patwadkar ◽  
Manohar V. Badiger ◽  
Rajesh G. Gonnade
Keyword(s):  
Anticancer Drug ◽  
Loop Diuretic ◽  
Salt Hydrate ◽  
Molecular Salt

Concomitant cocrystal and salt: no interconversion in the solid state

2019 ◽  
Vol 75 (3) ◽  
pp. 313-319
Author(s):  
Evgeniy A. Losev ◽  
Elena Boldyreva
Keyword(s):  
Phase Transition ◽  
Chemical Composition ◽  
Solid State ◽  
X Ray Diffraction ◽  
Melting Points ◽  
Polymorphic Transitions ◽  
X Ray ◽  
Temperature Range ◽  
Two Phases ◽  
Molecular Salt

A cocrystal and a molecular salt of β-alanine and DL-tartaric acid, C3H8NO2 +·C4H4O6 −, of the same chemical composition, were studied over a wide temperature range by single-crystal and powder X-ray diffraction. Neither the interconversion between the two phases nor any polymorphic transitions were observed in the temperature range from 100 K to the melting points. This contrasts with the solvent-mediated phase transition from the salt to the cocrystal in a slurry that has been documented earlier.

Mechanochemical dehydrochlorination and chelation reaction in the solid state: from a molecular salt to a coordination complex

CrystEngComm ◽  
2014 ◽  
Vol 16 (6) ◽  
pp. 969-973 ◽  
Author(s):  
Fang Guo ◽  
Hui-de Shao ◽  
Qi Yang ◽  
Antonino Famulari ◽  
Javier Martí-Rujas
Keyword(s):  
Solid State ◽  
Coordination Complex ◽  
Chelation Reaction ◽  
Molecular Salt

Preparation of Thin Cadmium Telluride Samples for Electron Microscope Studies

1974 ◽  
Vol 32 ◽  
pp. 548-549
Author(s):  
T. J. Magee ◽  
J. Peng ◽  
J. Bean
Keyword(s):  
Electron Microscope ◽  
Sulfuric Acid ◽  
Solid State ◽  
Sample Preparation ◽  
Cadmium Telluride ◽  
Potassium Dichromate ◽  
Optical Components ◽  
The Past ◽  
Solid State Devices

Cadmium telluride has become increasingly important in a number of technological applications, particularly in the area of laser-optical components and solid state devices, Microstructural characterizations of the material have in the past been somewhat limited because of the lack of suitable sample preparation and thinning techniques. Utilizing a modified jet thinning apparatus and a potassium dichromate-sulfuric acid thinning solution, a procedure has now been developed for obtaining thin contamination-free samples for TEM examination.

The Collagenic Molecular Structural Unit of Solid State Complexes

1971 ◽  
Vol 29 ◽  
pp. 478-479
Author(s):  
Kenneth M. Richter ◽  
John A. Schilling
Keyword(s):  
Molecular Weight ◽  
Solid State ◽  
Structural Unit ◽  
X Ray Diffraction ◽  
X Ray ◽  
Naoh Treatment

The structural unit of solid state collagen complexes has been reported by Porter and Vanamee via EM and by Cowan, North and Randall via x-ray diffraction to be an ellipsoidal unit of 210-270 A. length by 50-100 A. diameter. It subsequently was independently demonstrated by us in dog tendon, dermis, and induced complexes. Its detailed morphologic, dimensional and molecular weight (MW) aspects have now been determined. It is pear-shaped in long profile with m diameters of 57 and 108 A. and m length of 263 A. (Fig. 1, tendon, KMnO4 fixation, Na-tungstate; Fig. 2a, schematic of unit in long, C, and x-sectional profiles of its thin, xB, and bulbous, xA portions; Fig. 2b, tendon essentially unmodified by ether and 0.4 N NaOH treatment, Na-tungstate). The unit consists of a uniquely coild cable, c, of ṁ 22.9 A. diameter and length of 2580-3316 A. The cable consists of three 2nd-strands, s, each of m 10.6 A.

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