Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components

Abstract Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell disease. Symptomatic management and prevention of these events using the fetal hemoglobin–reactivating agent hydroxyurea are currently the mainstay of treatment. Discoveries over the past 2 decades have highlighted the important contributions of various cellular and soluble participants in the vaso-occlusive cascade. The role of these elements and the opportunities for therapeutic intervention are summarized in this review.

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Modern Concepts on the Role of Inflammation in Pulmonary Fibrosis

Archives of Pathology & Laboratory Medicine ◽

10.5858/2010-0296-ra.1 ◽

2011 ◽

Vol 135 (6) ◽

pp. 780-788 ◽

Cited By ~ 1

Author(s):

Robert J. Homer ◽

Jack A. Elias ◽

Chun Gun Lee ◽

Erica Herzog

Keyword(s):

Cell Death ◽

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Therapeutic Intervention ◽

Macrophage Polarization ◽

Critical Evaluation ◽

Clinical Context ◽

Disease Biomarkers ◽

Unpublished Research

Abstract Context.—Idiopathic pulmonary fibrosis is a uniformly lethal disease with limited biomarkers and no proven therapeutic intervention short of lung transplantation. Pulmonary fibrosis at one time was thought to be a result of inflammation in the lung. Although some forms of pulmonary fibrosis may result from inflammation, idiopathic pulmonary fibrosis is currently thought to result from cell death primarily and inflammation secondarily. Objective.—To determine the role of inflammation in pulmonary fibrosis in light of our laboratory's published and unpublished research and published literature. Data Sources.—Review based on our laboratory's published and unpublished experimental data with relevant background and clinical context provided. Conclusions.—Although cell death is central to pulmonary fibrosis, the proper cytokine environment leading to macrophage polarization is also critical. Evaluation of this environment is promising both for the development of disease biomarkers and for targets for therapeutic intervention.

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Medical Versus Surgical Treatment of Primary Vesicoureteral Reflux

PEDIATRICS ◽

10.1542/peds.67.3.392 ◽

1981 ◽

Vol 67 (3) ◽

pp. 392-400 ◽

Cited By ~ 6

Keyword(s):

Surgical Treatment ◽

Vesicoureteral Reflux ◽

Therapeutic Intervention ◽

Renal Damage ◽

Rational Basis ◽

Benefit Ratio ◽

International Trial ◽

Prospective Longitudinal ◽

Primary Vesicoureteral Reflux

The role of VUR in the development and progression of renal damage in children is universally acknowledged. The risk/benefit ratio of therapeutic intervention, whether medical or surgical, continues to be debated. This carefully controlled prospective, longitudinal, multispecialty, international trial aims to establish a rational basis for the treatment of VUR.

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