In vitro degradation and cell response of calcium carbonate composite ceramic in comparison with other synthetic bone substitute materials

2015 ◽  
Vol 50 ◽  
pp. 257-265 ◽  
Author(s):  
Fupo He ◽  
Jing Zhang ◽  
Fanwen Yang ◽  
Jixiang Zhu ◽  
Xiumei Tian ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Cell Response ◽  
Bone Substitute ◽  
Composite Ceramic ◽  
In Vitro Degradation ◽  
Synthetic Bone ◽  
Synthetic Bone Substitute ◽  
Bone Substitute Materials ◽  
Substitute Materials

scholarly journals Novel synthetic bone substitute materials based on dyaldehyde dextran

2021 ◽  
Vol 1 (Supplement) ◽  
Author(s):  
A. Luss ◽  
K. Kushnerev ◽  
E. Vlaskina ◽  
A. Chumakova ◽  
M. Shtilman ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Synthetic Bone ◽  
Synthetic Bone Substitute ◽  
Bone Substitute Materials ◽  
Substitute Materials

In vitro effects of particulate bone substitute materials on the resorption activity of human osteoclasts

2017 ◽  
Vol 34 ◽  
pp. 291-306 ◽  
Author(s):  
G Russmueller ◽  
◽  
L Winkler ◽  
R Lieber ◽  
R Seemann ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Bone Substitute Materials ◽  
In Vitro Effects ◽  
Substitute Materials ◽  
Human Osteoclasts

In Vitro and In Vivo Osteoinductive and Osteoconductive Properties of a Synthetic Bone Substitute

2013 ◽  
Vol 28 (6) ◽  
pp. e432-e439 ◽  
Author(s):  
Enrico Conserva ◽  
Federico Foschi ◽  
Ranieri Cancedda ◽  
Maddalena Mastrogiacomo
Keyword(s):  
Bone Substitute ◽  
Synthetic Bone ◽  
Synthetic Bone Substitute

scholarly journals Influence of Absorbable Calcium Sulfate-Based Bone Substitute Materials on Human Haemostasis—In Vitro Biological Behavior of Antibiotic Loaded Implants

Materials ◽  
2018 ◽  
Vol 11 (6) ◽  
pp. 935 ◽  
Author(s):  
Dominik Pförringer ◽  
Norbert Harrasser ◽  
Marc Beirer ◽  
Moritz Crönlein ◽  
Axel Stemberger ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Calcium Sulfate ◽  
Biological Behavior ◽  
Bone Substitute Materials ◽  
Substitute Materials

scholarly journals Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate

2016 ◽  
Vol 60 (7) ◽  
pp. 3897-3905 ◽  
Author(s):  
D. Pförringer ◽  
A. Obermeier ◽  
M. Kiokekli ◽  
H. Büchner ◽  
S. Vogt ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Ex Vivo ◽  
Release Kinetics ◽  
Drug Carriers ◽  
Prolonged Release ◽  
Clinical Parameters ◽  
Bone Substitute Materials ◽  
Substitute Materials

ABSTRACTSubstitution of bones is a well-established, necessary procedure to treat bone defects in trauma and orthopedic surgeries. For prevention or treatment of perioperative infection, the implantation of resorbable bone substitute materials carrying antibiotics is a necessary treatment. In this study, we investigated the newly formulated calcium-based resorbable bone substitute materials containing either gentamicin (CaSO4-G [Herafill-G]), vancomycin (CaSO4-V), or tobramycin (Osteoset). We characterized the released antibiotic concentration per unit. Bone substitute materials were implanted in bones of rabbits via a standardized surgical procedure. Clinical parameters and levels of the antibiotic-releasing materials in serum were determined. Local concentrations of antibiotics were measured using antimicrobial tests of bone tissue. Aminoglycoside release kineticsin vitroper square millimeter of bead surface showed the most prolonged release for gentamicin, followed by vancomycin and, with the fastest release, tobramycin.In vivolevel in serum detected over 28 days was highest for gentamicin at 0.42 μg/ml, followed by vancomycin at 0.11 μg/ml and tobramycin at 0.04 μg/ml. The clinical parameters indicated high biocompatibility for materials used. None of the rabbits subjected to the procedure showed any adverse reaction. The highest availability of antibiotics at 14.8 μg/g on day 1 in the cortical tibiaex vivowas demonstrated for gentamicin, decreasing within 14 days. In the medulla, vancomycin showed a high level at 444 μg/g on day 1, decreasing continuously over 14 days, whereas gentamicin decreased faster within the initial 3 days. The compared antibiotic formulations varied significantly in release kinetics in serum as well as locally in medulla and cortex.

The study on calcium polyphosphate/poly-amino acid composite for supportive bone substitute materials in vitro

2021 ◽  
Author(s):  
Jinbo Hu ◽  
Rongguang Zhang ◽  
Hong Chen ◽  
Yanan Wu ◽  
Lichao Chen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Mechanical Strength ◽  
Human Body ◽  
Bone Substitute ◽  
Calcium Polyphosphate ◽  
Proliferation And Differentiation ◽  
Bone Substitute Materials ◽  
Substitute Materials ◽  
The Ideal

In addition to the sufficient mechanical strength to burden the force of the human body, the ideal supporting implant material should have bioactivity to stimulate the cells proliferation and differentiation...

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