scholarly journals Influence of Absorbable Calcium Sulfate-Based Bone Substitute Materials on Human Haemostasis—In Vitro Biological Behavior of Antibiotic Loaded Implants

Materials ◽  
2018 ◽  
Vol 11 (6) ◽  
pp. 935 ◽  
Author(s):  
Dominik Pförringer ◽  
Norbert Harrasser ◽  
Marc Beirer ◽  
Moritz Crönlein ◽  
Axel Stemberger ◽  
...  
2017 ◽  
Vol 34 ◽  
pp. 291-306 ◽  
Author(s):  
G Russmueller ◽  
◽  
L Winkler ◽  
R Lieber ◽  
R Seemann ◽  
...  

2016 ◽  
Vol 60 (7) ◽  
pp. 3897-3905 ◽  
Author(s):  
D. Pförringer ◽  
A. Obermeier ◽  
M. Kiokekli ◽  
H. Büchner ◽  
S. Vogt ◽  
...  

ABSTRACTSubstitution of bones is a well-established, necessary procedure to treat bone defects in trauma and orthopedic surgeries. For prevention or treatment of perioperative infection, the implantation of resorbable bone substitute materials carrying antibiotics is a necessary treatment. In this study, we investigated the newly formulated calcium-based resorbable bone substitute materials containing either gentamicin (CaSO4-G [Herafill-G]), vancomycin (CaSO4-V), or tobramycin (Osteoset). We characterized the released antibiotic concentration per unit. Bone substitute materials were implanted in bones of rabbits via a standardized surgical procedure. Clinical parameters and levels of the antibiotic-releasing materials in serum were determined. Local concentrations of antibiotics were measured using antimicrobial tests of bone tissue. Aminoglycoside release kineticsin vitroper square millimeter of bead surface showed the most prolonged release for gentamicin, followed by vancomycin and, with the fastest release, tobramycin.In vivolevel in serum detected over 28 days was highest for gentamicin at 0.42 μg/ml, followed by vancomycin at 0.11 μg/ml and tobramycin at 0.04 μg/ml. The clinical parameters indicated high biocompatibility for materials used. None of the rabbits subjected to the procedure showed any adverse reaction. The highest availability of antibiotics at 14.8 μg/g on day 1 in the cortical tibiaex vivowas demonstrated for gentamicin, decreasing within 14 days. In the medulla, vancomycin showed a high level at 444 μg/g on day 1, decreasing continuously over 14 days, whereas gentamicin decreased faster within the initial 3 days. The compared antibiotic formulations varied significantly in release kinetics in serum as well as locally in medulla and cortex.


2021 ◽  
Author(s):  
Jinbo Hu ◽  
Rongguang Zhang ◽  
Hong Chen ◽  
Yanan Wu ◽  
Lichao Chen ◽  
...  

In addition to the sufficient mechanical strength to burden the force of the human body, the ideal supporting implant material should have bioactivity to stimulate the cells proliferation and differentiation...


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