Targeted delivery and controlled release of doxorubicin into cancer cells using a multifunctional graphene oxide

Carboxyl single-walled carbon nanotubes (SWNTs) were used to construct an innovative drug delivery system by modification with chitosan (CHI) to enhance water solubility and biocompatibility.

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Folate receptor targeted delivery of paclitaxel to breast cancer cells via folic acid conjugated graphene oxide grafted methyl acrylate nanocarrier

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2018.12.008 ◽

2019 ◽

Vol 110 ◽

pp. 906-917 ◽

Cited By ~ 24

Author(s):

Kandasamy Vinothini ◽

Naresh Kumar Rajendran ◽

Andy Ramu ◽

Nandhakumar Elumalai ◽

Mariappan Rajan

Keyword(s):

Breast Cancer ◽

Graphene Oxide ◽

Folic Acid ◽

Cancer Cells ◽

Methyl Acrylate ◽

Targeted Delivery ◽

Breast Cancer Cells ◽

Folate Receptor

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Smart aptamer-modified calcium carbonate nanoparticles for controlled release and targeted delivery of epirubicin and melittin into cancer cells in vitro and in vivo

Drug Development and Industrial Pharmacy ◽

10.1080/03639045.2019.1569029 ◽

2019 ◽

Vol 45 (4) ◽

pp. 603-610 ◽

Cited By ~ 10

Author(s):

Rezvan Yazdian-Robati ◽

Atefeh Arab ◽

Mohammad Ramezani ◽

Houshang Rafatpanah ◽

Amirhossein Bahreyni ◽

...

Keyword(s):

Calcium Carbonate ◽

Controlled Release ◽

Cancer Cells ◽

Targeted Delivery

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Targeted delivery and controlled release of doxorubicin to cancer cells by smart ATP-responsive Y-shaped DNA structure-capped mesoporous silica nanoparticles

Journal of Materials Chemistry B ◽

10.1039/d0tb01960g ◽

2021 ◽

Vol 9 (5) ◽

pp. 1351-1363 ◽

Cited By ~ 1

Author(s):

Elnaz Bagheri ◽

Mona Alibolandi ◽

Khalil Abnous ◽

Seyed Mohammad Taghdisi ◽

Mohammad Ramezani

Keyword(s):

Controlled Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Cancer Cells ◽

Delivery System ◽

Targeted Delivery ◽

Mesoporous Silica Nanoparticles ◽

Dna Structure ◽

Targeted Delivery System

In this study, a dual-receptor doxorubicin-targeted delivery system based on mesoporous silica nanoparticles (MSNs) modified with mucine-1 and ATP aptamers (DOX@MSNs-Apts) was developed.

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Targeted Delivery of siRNA to Ovarian Cancer Cells Using Functionalized Graphene Oxide

Nano LIFE ◽

10.1142/s1793984418500010 ◽

2018 ◽

Vol 08 (01) ◽

pp. 1850001 ◽

Cited By ~ 1

Author(s):

Shibin Du ◽

Yunfei Wang ◽

Junping Ao ◽

Kai Wang ◽

Zhiying Zhang ◽

...

Keyword(s):

Ovarian Cancer ◽

Graphene Oxide ◽

Gene Delivery ◽

Cancer Cells ◽

Targeted Delivery ◽

Small Interfering Rna ◽

Folate Receptor ◽

Ovarian Cancer Cells ◽

Functionalized Graphene Oxide ◽

Interfering Rna

Ovarian cancer is the highest mortality rate of all cancers in the female reproductive system. Over the past decades, small interfering RNA (si RNA) has been explored as a promising therapeutic candidate for gene therapy. However, its clinical application is limited by the lack of safe and efficient methods for gene delivery. Graphene oxide (GO) was modified with polyethylene glycol (PEG), polyethylenimine (PEI) and folic acid (FA), for targeted delivery of small interfering RNA (siRNA) that inhibits ovarian cancer cell growth, and the efficacy of such complex was evaluated by a series of in vitro experiments. The synthesized vehicle PEG-GO-PEI-FA was characterized by atomic force microscopy (AFM), Malvern particle size analyzer, UV-visible spectroscopy and Fourier transform infrared spectroscopy (FTIR), and the results showed that PEG, PEI and FA could be covalently grafted to GO surface, forming PEG-GO-PEI-FA particles with a size of [Formula: see text][Formula: see text]nm and a potential of 14.7[Formula: see text]mV. Agarose-gel electrophoresis demonstrated that siRNA can be adsorbed onto the surface of PEG-GO-PEI-FA by electrostatic interaction. Laser confocal microscopy demonstrated that siRNA-adsorbed PEG-GO-PEI-FA could be target into folate receptor (FR)-overexpressing ovarian cancer cells. Compared to the PEG-GO-PEI/siRNA without folate modification, PEG-GO-PEI-FA/siRNA showed more pronounced inhibitory effect on growth of ovarian cancer cells. In conclusion, we have successfully synthesized a vector that is safe, efficient and specific to target tumor cell for gene delivery.

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