Evaluation of inhibitory effects of geniposide on a tumor model of human breast cancer based on 3D printed Cs/Gel hybrid scaffold

2021 ◽  
Vol 119 ◽  
pp. 111509
Author(s):  
Kena Lv ◽  
Jingjing Zhu ◽  
Shuangshuang Zheng ◽  
Zeren Jiao ◽  
Yi Nie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Tumor Model ◽  
Human Breast ◽  
Inhibitory Effects ◽  
Hybrid Scaffold ◽  
3D Printed

scholarly journals Silibinin, up-regulates chemokine receptor expression in MDA-MB-231 breast cancer cell line

2015 ◽  
Vol 14 (2) ◽  
pp. 190-195
Author(s):  
Nikoo Khannazer ◽  
Seyed Hassan Paylakhi ◽  
Abbas Mirshafiey ◽  
Gholamreza Azizi ◽  
Nasrin Motamed
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Breast Cancer Cell ◽  
Chemokine Receptor ◽  
Mtt Assay ◽  
Human Breast Cancer ◽  
Receptor Expression ◽  
Time Dependent ◽  
Human Breast ◽  
Inhibitory Effects

Introduction: Silibinin, a polyphenolic flavonoid isolated from the milk thistle plant (Silybummarianum), has various applications in cancer therapy. This investigation aimed to examine the effects of silibinin on proliferation and chemokine receptor expression on MDA-MB-231 cells, a highly metastatic human breast cancer cell line.Methods: The cytotoxic effect of silibinin on MDA-MB-231 cells was determined by micro-culture tetrazolium test (MTT) assay. In addition, the expression of chemokine receptors CXCR3, CCR5 and CCR7 genes in response to silibinin was evaluated by Real-Time PCR.Results: Data analysis from MTT assay showed that silibinin had dose-dependent and time-dependent inhibitory effects on MDA-MB-231 cell line. Moreover, Real-Time PCR analysis showed that silibinin not only had no inhibitory effects on CXCR3, CCR5 and CCR7 gene expressions, but also could increase significantly the expression of these genes in a dose and time-dependent manner.Conclusion: These results revealed for the first time the increased possibility of CXCR3, CCR5 and CCR7 genes expression in response to silibinin in human breast cancer cells.Bangladesh Journal of Medical Science Vol.14(2) 2015 p.190-195

Digitoxin enhances the growth inhibitory effects of thapsigargin and simvastatin on ER negative human breast cancer cells

Fitoterapia ◽  
2016 ◽  
Vol 109 ◽  
pp. 146-154 ◽  
Author(s):  
Linda Saxe Einbond ◽  
Hsan-au Wu ◽  
Cristinel Sandu ◽  
Margaret Ford ◽  
Jason Mighty ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Inhibitory Effects ◽  
Growth Inhibitory
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