scholarly journals Bactericidal potential of dual-ionic honeycomb-like ZnO-CuO nanocomposites from Calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: Staphylococcus aureus

2021 ◽  
Vol 4 ◽  
pp. 383-390
Author(s):  
G Ambarasan Govindasamy ◽  
Rabiatul Basria S. M. N. Mydin ◽  
Nor Hazliana Harun ◽  
Srimala Sreekantan
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Infections ◽  
Surgical Wound ◽  
Calotropis Gigantea

scholarly journals Association of Borderline Oxacillin-Susceptible Strains of Staphylococcus aureus with Surgical Wound Infections

1998 ◽  
Vol 36 (1) ◽  
pp. 219-222 ◽  
Author(s):  
Douglas S. Kernodle ◽  
David C. Classen ◽  
Charles W. Stratton ◽  
Allen B. Kaiser
Keyword(s):  
Staphylococcus Aureus ◽  
Type A ◽  
The United States ◽  
In Vitro Assays ◽  
Wound Infections ◽  
Surgical Wound ◽  
Prophylactic Regimen ◽  
Phage Group ◽  
Group 5

Staphylococcus aureus isolates which produce type A staphylococcal β-lactamase have been associated with wound infections complicating the use of cefazolin prophylaxis in surgery. To further evaluate this finding, 215 wound isolates from 14 cities in the United States were characterized by antimicrobial susceptibility and β-lactamase type and correlated with the preoperative prophylactic regimen. Borderline-susceptible S. aureus isolates of phage group 5 (BSSA-5), which produce large amounts of type A β-lactamase and exhibit borderline susceptibility to oxacillin, comprised a greater percentage of the 120 wound isolates associated with cefazolin prophylaxis than they did of the 95 isolates associated with other prophylactic regimens (25% versus 12.6%, respectively;P < 0.05). In contrast, methicillin-resistantS. aureus isolates were distributed evenly between the two groups (8.3% versus 11.6%, respectively). In vitro assays demonstrated that cefazolin was hydrolyzed faster by BSSA-5 strains than by other β-lactamase-producing, methicillin-susceptible strains (1.54 versus 0.50 μg/min/108 CFU, respectively;P < 0.0001). These data demonstrate that BSSA-5 strains are a distinct subpopulation of methicillin-susceptibleS. aureus which frequently cause deep surgical wound infections. Cefazolin use in prophylaxis is a risk factor for BSSA-5 infection.

scholarly journals Hyaluronic Acid Binding Peptides Prevent Experimental Staphylococcal Wound Infection

2006 ◽  
Vol 50 (11) ◽  
pp. 3856-3860 ◽  
Author(s):  
Kathleen J. Zaleski ◽  
Tadeusz Kolodka ◽  
Colette Cywes-Bentley ◽  
Rachel M. McLoughlin ◽  
Mary L. Delaney ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Hyaluronic Acid ◽  
Host Response ◽  
Host Responses ◽  
Wound Infections ◽  
Surgical Wound ◽  
Wound Site ◽  
Novel Approach ◽  
Binding Peptides ◽  
Hyaluronic Acid Binding

ABSTRACT Staphylococcus aureus is a major cause of surgical wound infections. The development of mechanisms of antimicrobial resistance by this and other bacterial pathogens has prompted the search for new approaches to treat infectious diseases. Hyaluronic acid binding peptides have been shown to modulate cellular trafficking during host responses and were assessed for their ability to treat and possibly prevent experimental surgical wound infections caused by S. aureus. Treatment with these peptides was highly efficacious in reducing the number of S. aureus cells at the wound site and ameliorated the inflammatory host response associated with these infections. These data suggest a novel approach for the treatment and prophylaxis of staphylococcal wound infections in the clinical setting.

scholarly journals Sensitivity and resistance of microorganisms in infected surgical wounds on surgical floor of Mayo Hospital

2016 ◽  
Vol 11 (3) ◽  
Author(s):  
Muhammad Ahmad Ghazi ◽  
Yasir Akram ◽  
Yasir Akram ◽  
Cheema M A ◽  
Cheema M A
Keyword(s):  
Staphylococcus Aureus ◽  
General Surgery ◽  
Resistance Pattern ◽  
Wound Infections ◽  
Surgical Wound ◽  
Surgical Wounds ◽  
Culture Sensitivity ◽  
The World ◽  
Resistant Strains ◽  
The Common

Background: There is an overwhelming concern around the world regarding the increasing number of resistant strains of microorganisms in all sorts of wounds. There is hardly any information about the prevalence and incidence of such resistance pattern in our local hospitals Methods: This study was done to probe into the common microorganisms and their culture sensitivities to antibiotics in surgical wound infections in general surgery wards of Mayo hospital. The study material included the pus specimens sent to pathology lab from general surgical wards. There culture sensitivity results were interpreted to find out the prevalence of individual microorganisms in surgical wounds and sensitivities and resistance to different antibiotics. Results: Staphylococcus aureus was the most common organism cultured (54.87%), followed by E.Coli (10%), pseudomonas(10%), proteus (7.9%) and kleibsiella (5.3%). 20 percent of wounds had mixed growth of organisms. Mixed growth of microorganisms was seen in 20% of cases. Conclusion: Most of the bacteria cultured were resistant to routinely used antibiotics.

scholarly journals A resistant culture - ?superbugs? in Australian hospitals

2007 ◽  
Vol 28 (4) ◽  
pp. 184
Author(s):  
G L Gilbert
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Antimicrobial Resistance ◽  
Phage Type ◽  
Aureus Strain ◽  
Wound Infections ◽  
Soft Tissue Infections ◽  
Surgical Wound ◽  
Alfred Hospital ◽  
General Community

Antimicrobial resistance is not new in Australian hospitals. In 1946, shortly after penicillin became available for treatment of civilians, a penicillin resistant Staphylococcus aureus strain caused ~50% of staphylococcal surgical wound infections at the Royal Prince Alfred Hospital (RPAH), in Sydney. During the 1950s, another virulent penicillin resistant S. aureus strain (phage type 80/81) emerged in neonatal units in Sydney and spread to other hospitals in Australia and overseas, to the families of affected infants and to the general community, causing serious soft tissue infections, osteomyelitis, pneumonia and septicaemia.

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