Efficacy of biopolymeric PVA-AuNPs and PCL-Curcumin loaded electrospun nanofibers and their anticancer activity against A431 skin cancer cell line

Background: Hydrazones, one of the important classes of organic molecules, are pharmaceutical agents comprising –CO-NH-N=CH- group in the structure therefore and exhibiting significant biological activity. Methods: 5-Chloro-N’-[(substituted)methylidene] pyrazine-2-carbohydrazide (3a-g) and their Pd(II) complexes (4a-h) were synthesized and investigated in vitro anticancer activity on A549, Caco2 cancer and normal 3T3 fibroblast cell lines, using the MTT assay. Results: Anticancer activity screening results revealed that some compounds showed remarkable cytotoxic effect. Among them, 5-chloro-N'-[(4-hydroxyphenyl)methylidene] pyrazine-2-carbohydrazide (3c) displayed higher cytotoxic activity against A549 cancer cell line than the reference drug cisplatin. Conclusion: Compound 3c showed high cytotoxic activity against A549 cancer cell line but it showed low cytotoxic effect against normal 3T3 fibroblast cell line. Antiproliferative and antimetastatic effects of 3c were determined by the real-time monitoring of cell proliferative system (RTCA DP). The cell proliferation, metastatic and invasive activities of A549 cells were decreased due to increased concentration of 3c.

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Correction: Gobinath, P., et al. Grindstone Chemistry: Design, One-Pot Synthesis, and Promising Anticancer Activity of Spiro[acridine-9,2′-indoline]-1,3,8-trione Derivatives against the MCF-7 Cancer Cell Line. Molecules 2020, 25, 5862

Molecules ◽

10.3390/molecules26041131 ◽

2021 ◽

Vol 26 (4) ◽

pp. 1131

Author(s):

Perumal Gobinath ◽

Ponnusamy Packialakshmi ◽

Ali Daoud ◽

Saud Alarifi ◽

Akbar Idhayadhulla ◽

...

Keyword(s):

Anticancer Activity ◽

Cell Line ◽

Cancer Cell ◽

Cancer Cell Line ◽

One Pot ◽

One Pot Synthesis ◽

Mcf 7

In the original article [...]

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Nanomedicinary evaluation of calotropis procera mediated silver nanoparticle on skin cancer cell line for microbes-front line analysis

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.130237 ◽

2021 ◽

pp. 130237

Author(s):

Sumathy Raj ◽

Divya Muthu ◽

R S Rimal Isaac ◽

Subhashini Ramakrishnan ◽

Anooj E S ◽

...

Keyword(s):

Skin Cancer ◽

Cell Line ◽

Cancer Cell ◽

Silver Nanoparticle ◽

Cancer Cell Line ◽

Calotropis Procera ◽

Front Line ◽

Line Analysis

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Hydrothermal synthesis of pure and bio modified TiO2: Characterization, evaluation of antibacterial activity against gram positive and gram negative bacteria and anticancer activity against KB Oral cancer cell line

Arabian Journal of Chemistry ◽

10.1016/j.arabjc.2018.11.020 ◽

2020 ◽

Vol 13 (1) ◽

pp. 3484-3497 ◽

Cited By ~ 8

Author(s):

P. Maheswari ◽

S. Ponnusamy ◽

S. Harish ◽

M.R. Ganesh ◽

Y. Hayakawa

Keyword(s):

Antibacterial Activity ◽

Hydrothermal Synthesis ◽

Oral Cancer ◽

Anticancer Activity ◽

Cell Line ◽

Cancer Cell ◽

Cancer Cell Line ◽

Gram Negative Bacteria ◽

Gram Negative ◽

Oral Cancer Cell Line

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Promising Anticancer Activity of [Bis(1,8-quinolato)palladium (II)] Alone and in Combination

10.21203/rs.3.rs-106007/v1 ◽

2020 ◽

Author(s):

Md. Nur Alam ◽

Mohammad Moni ◽

Jun Yu ◽

Philip Beale ◽

Peter Turner ◽

...

Keyword(s):

Colorectal Cancer ◽

Anticancer Activity ◽

Cell Line ◽

Cell Lines ◽

Cancer Cell ◽

Antitumour Activity ◽

Epigallocatechin Gallate ◽

Cancer Cell Line ◽

Resistant Cell ◽

Colorectal Cancer Cell Line

Abstract Due to similar coordination chemistry of palladium and platinum, a large number of palladium compounds too have been investigated for their anticancer activity. In the present study we describe synthesis, characterization and anticancer activity of palladium complex [Bis(1,8-quinolato)palladium (II)], coded as NH3 against seven different cancer cell lines. NH3 is found to have higher antitumour activity than cisplatin against both parent ovarian A2780 cell line and cisplatin-resistant cell lines. Also, NH3 has the lowest IC50 value against HT-29 colorectal cancer cell line. The higher antitumour activity of NH3 is due to the presence of bulky 8-hydroxy-quinoline ligand thus reducing its reactivity. Proteomic study has identified significantly expressed proteins which have been validated through bioinformatics. NH3 has been found to be less toxic than cisplatin at 2.5 mg/kg and 5 mg/kg dosages on mice models. Binary combinations of NH3 with curcumin and epigallocatechin gallate (EGCG) have demonstrated dose and sequence dependent synergism in ovarian and colorectal cancer models. All of the preclinical studies indicate promising therapeutic potentiality of NH3 [Bis(1,8-quinolato)palladium (II) ] as an anticancer drug.

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