Nano ZnO imprinted dextran hybrid poly (N-isopropylacrylamide)/poly ethylene glycol composite hydrogels for in vitro release of ciprofloxacin

2020 ◽  
pp. 101869
Author(s):  
Kalyani Prusty ◽  
Swapnita Patra ◽  
Sarat K. Swain
Keyword(s):  
Ethylene Glycol ◽  
In Vitro Release ◽  
Poly Ethylene Glycol ◽  
Nano Zno ◽  
Composite Hydrogels ◽  
Poly Ethylene ◽  
Vitro Release

In vitro release of plasmid DNA from oligo(poly(ethylene glycol) fumarate) hydrogels

2005 ◽  
Vol 104 (3) ◽  
pp. 521-539 ◽  
Author(s):  
F. Kurtis Kasper ◽  
Stephanie K. Seidlits ◽  
Andrew Tang ◽  
Roger S. Crowther ◽  
Darrell H. Carney ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Plasmid Dna ◽  
In Vitro Release ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Vitro Release

Methoxy-Poly(ethylene glycol)-block-Poly(ε-caprolactone) Bearing Pendant Aldehyde Groups as pH-Responsive Drug Delivery Carrier

2013 ◽  
Vol 66 (12) ◽  
pp. 1576 ◽  
Author(s):  
Gejun Ma ◽  
Deshan Li ◽  
Ji Wang ◽  
Xuefei Zhang ◽  
Haoyu Tang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
In Vitro Release ◽  
Amphiphilic Block Copolymer ◽  
Poly Ethylene Glycol ◽  
Ph Change ◽  
Poly Ethylene ◽  
Aldehyde Groups

A biodegradable amphiphilic block copolymer of methoxy poly(ethylene glycol)-block-poly(ϵ-caprolactone) bearing pendant aldehyde groups was synthesised by a combination of ring-opening polymerisation and thio-bromo ‘click’ chemistry. The free aldehyde groups on the copolymer were reacted with hydrophobic payloads (p-methoxylaniline as a model drug) by a benzoic–imine linker, which was responsive to pH change. NMR, FTIR, and gel permeation chromatography analysis confirmed the copolymer structures. In vitro release studies revealed that under acid stimulus, hydrolysis of the benzoic–imine bond resulted in a rapid drug release. This new amphiphilic block copolymer is expected to have promising applications in biodegradable controlled drug delivery systems.

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