Bio-inspired hard-to-soft interface for implant integration to bone

Hydroxyapatite (HA) and other forms of bioceramics coatings had been reported to stimulate bone healing, which helps in initial implant integration. This study was to evaluate the effectiveness of air blasting with two combinations of bioceramic powders (hydroxyapatite and calcium oxide) on the selected implant surfaces for surface deposition. Five different types of implant disks were tested, namely Commercially pure (Cp), Sandblasted (SB), Sandblasted and etched(SBE), SLActive®, Roxolid®. The studied samples were blasted with apatite abrasive bioceramic powders, 95% Hydroxyapatite (HA)/5% Calcium Oxide (CaO) and 90% Hydroxyapatite (HA)/10% Calcium Oxide (CaO). The surface and elemental differences between the blasted samples were compared using a Scanning Electron Microscope (SEM) and Energy Dispersive Spectroscopy (EDS). Results after surface treatment had demonstrated changes in surface morphologies; most evidently on the Cp implant discs. All treated surfaces revealed a non-uniform distribution of the treatment on the surface layer, with dispersed patches of bioceramic powders over the surfaces. The experimental blasting method used in this study has demonstrated the ability to deposit bioceramic materials on different implant surfaces.

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Primary stability: The password of implant integration

Journal of Dental Implants ◽

10.4103/0974-6781.102223 ◽

2012 ◽

Vol 2 (2) ◽

pp. 103 ◽

Cited By ~ 5

Author(s):

Amreena Gill ◽

PolsaniLaxman Rao

Keyword(s):

Primary Stability ◽

Implant Integration

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Sustained Calcium(II)-Release to Impart Bioactivity in Hybrid Glass Scaffolds for Bone Tissue Engineering

Pharmaceutics ◽

10.3390/pharmaceutics12121192 ◽

2020 ◽

Vol 12 (12) ◽

pp. 1192

Author(s):

Dzmitry Kuzmenka ◽

Claudia Sewohl ◽

Andreas König ◽

Tobias Flath ◽

Sebastian Hahnel ◽

...

Keyword(s):

Cell Culture ◽

Bone Tissue ◽

Culture Medium ◽

Calcium Release ◽

Burst Release ◽

Cell Culture Medium ◽

Mineral Layer ◽

Additional Increase ◽

Implant Integration ◽

Ph Increase

In this study, we integrated different calcium sources into sol-gel hybrid glass scaffolds with the aim of producing implants with long-lasting calcium release while maintaining mechanical strength of the implant. Calcium(II)-release was used to introduce bioactivity to the material and eventually support implant integration into a bone tissue defect. Tetraethyl orthosilicate (TEOS) derived silica sols were cross-linked with an ethoxysilylated 4-armed macromer, pentaerythritol ethoxylate and processed into macroporous scaffolds with defined pore structure by indirect rapid prototyping. Triethyl phosphate (TEP) was shown to function as silica sol solvent. In a first approach, we investigated the integration of 1 to 10% CaCl2 in order to test the hypothesis that small CaCl2 amounts can be physically entrapped and slowly released from hybrid glass scaffolds. With 5 and 10% CaCl2 we observed an extensive burst release, whereas slightly improved release profiles were found for lower Calcium(II) contents. In contrast, introduction of melt-derived bioactive 45S5 glass microparticles (BG-MP) into the hybrid glass scaffolds as another Calcium(II) source led to an approximately linear release of Calcium(II) in Tris(hydroxymethyl)aminomethane (TRIS) buffer over 12 weeks. pH increase caused by BG-MP could be controlled by their amount integrated into the scaffolds. Compression strength remained unchanged compared to scaffolds without BG-MP. In cell culture medium as well as in simulated body fluid, we observed a rapid formation of a carbonated hydroxyapatite layer on BG-MP containing scaffolds. However, this mineral layer consumed the released Calcium(II) ions and prevented an additional increase in Calcium(II) concentration in the cell culture medium. Cell culture studies on the different scaffolds with osteoblast-like SaOS-2 cells as well as bone marrow derived mesenchymal stem cells (hMSC) did not show any advantages concerning osteogenic differentiation due to the integration of BG-MP into the scaffolds. Nonetheless, via the formation of a hydroxyapatite layer and the ability to control the pH increase, we speculate that implant integration in vivo and bone regeneration may benefit from this concept.

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Qualitative evaluation of titanium implant integration into bone by diffraction enhanced imaging

Physics in Medicine and Biology ◽

10.1088/0031-9155/51/5/019 ◽

2006 ◽

Vol 51 (5) ◽

pp. 1313-1324 ◽

Cited By ~ 30

Author(s):

A Wagner ◽

A Sachse ◽

M Keller ◽

M Aurich ◽

W-D Wetzel ◽

...

Keyword(s):

Qualitative Evaluation ◽

Titanium Implant ◽

Diffraction Enhanced Imaging ◽

Implant Integration ◽

Enhanced Imaging

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Measuring shear wave velocity, Vs, of a hidden layer: an application to soil improvement under roads

Canadian Geotechnical Journal ◽

10.1139/cgj-2014-0125 ◽

2015 ◽

Vol 52 (6) ◽

pp. 721-731 ◽

Cited By ~ 4

Author(s):

Francesco Mulargia ◽

Silvia Castellaro ◽

Gianluca Vinco

Keyword(s):

Seismic Source ◽

Soil Improvement ◽

Rigid Surface ◽

Specific Kind ◽

Viable Option ◽

The Past ◽

Alternative Approach ◽

Hidden Layer ◽

The Waves ◽

Soft Interface

In a number of practical cases, a typical one being the investigation of the subsoil properties below roads or foundations, one faces the problem of measuring the elastic properties of a geological layer (here called “hidden layer”) underlying a more compact and rigid surface layer. In such cases, the effectiveness of common surface seismic methods is poor for different reasons, but mostly linked to the reflection–transmission properties of the waves at a stiff-to-soft interface. Borehole methods are more efficient, but expensive and only provide vertical information at certain points. Attempts carried out in the past to characterize the hidden layer properties through surface seismic techniques consisted in placing the seismic source on the surface alongside, but off the stiff artificial layer (road or foundation). An alternative approach is presented based on placing the seismic source just below the stiff artificial layer. In cases where soil improvement–compaction are carried out through injection of expanding resins, then the hidden layer can be easily reached via the injecting tools and in some cases (e.g., urban settings characterized by laterally continuous artificial layers or roads constructed on embankments) this can be the only viable option. The results obtained from this approach using a number of practical cases where roads affected by differential sinking have later been compacted will be presented. The average soil improvement that can be achieved with the specific kind of expanding resin used in this study is then quantified.

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