Ellagic acid–Fe nanoscale coordination polymer with higher longitudinal relaxivity for dual-modality T1-weighted magnetic resonance and photoacoustic tumor imaging

2020 ◽  
Vol 28 ◽  
pp. 102219
Author(s):  
Qiwei Tian ◽  
Yu Cai ◽  
Nan Li ◽  
Qiufang Liu ◽  
Bingxin Gu ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Ellagic Acid ◽  
Tumor Imaging ◽  
Dual Modality ◽  
Longitudinal Relaxivity ◽  
Nanoscale Coordination Polymer

Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo

2017 ◽  
Vol 5 (44) ◽  
pp. 8761-8769 ◽  
Author(s):  
Congyang Yan ◽  
Lili Cui ◽  
Qi Yang ◽  
Xiaobao Zhou ◽  
Lixing Pan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Mr Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Dual Modality ◽  
Dual Modality Imaging

Coordination polymer hybridized Au nanocages (AuNC@CPs) were prepared, which were used for near-infrared (NIR)-driven photothermal therapy (PTT) guided by photoacoustic (PA) and magnetic resonance (MR) imaging in vivo.

Robust dual modality antibacterial action using silver-Prussian blue nanoscale coordination polymer

2020 ◽  
Vol 113 ◽  
pp. 110982
Author(s):  
Shalini Sharma ◽  
Nayanika Chakraborty ◽  
Diksha Jha ◽  
Hemant Kumar Gautam ◽  
Indrajit Roy
Keyword(s):  
Coordination Polymer ◽  
Prussian Blue ◽  
Antibacterial Action ◽  
Dual Modality ◽  
Nanoscale Coordination Polymer

Surface morphology and payload synergistically caused an enhancement of the longitudinal relaxivity of a Mn3O4/PtOx nanocomposite for magnetic resonance tumor imaging

2021 ◽  
Author(s):  
Sihan Ji ◽  
Yaodong Chen ◽  
Xianglong Zhao ◽  
Yunyu Cai ◽  
Xiaopeng Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Surface Morphology ◽  
Tumor Imaging ◽  
Longitudinal Relaxivity ◽  
Porous Morphology

A surface porous morphology and PtOx payload synergistically induced an enhancement of the r1 value to 20.48 mM−1 s−1 in a Mn3O4/PtOx nanocomposite for MR imaging.

Preparation of Gd-Au Dendrimer-Entrapped Gold Nanoparticles-Folic Acid Nanoparticles and Its Application in Computed Tomography/Magnetic Resonance Imaging Dual-Modality Diagnosis of Abdominal Tumors

2021 ◽  
Vol 13 (7) ◽  
pp. 1364-1373
Author(s):  
Yumei Zhang ◽  
Ruina Pei ◽  
Tao Luo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Receptor Expression ◽  
Average Particle ◽  
Resonance Imaging ◽  
Dual Modality ◽  
Abdominal Tumors

ABSTRACTThe development of nanomaterials, especially the development of multi-modality imaging nanoprobe technology has become a reality for tumor imaging diagnosis. In this study, the gadolinium ion chelating agent (2,2′,2′′-(10-(2-(2, 5-dioxopyrrolidin-1-oxyl)-2 oxoethyl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-tri)triacetic acid) (DOTA-NHS) and polyethylene glycol (PEG)-modified targeting ligand PEG-folic acid (FA) were grafted onto the PEG-modified fifth-generation polyamide-amine dendrimer (P5-NH2), which were undertaken as standards to wrap gold nanoparticles. Then, remaining amino group was acetylated to acquire Gd–Au DENPS-FA nanoparticles. Biocompatibility and cytotoxicity of nanoparticles were analyzed while characterizing them. The cases with unidentified tumors (mass diameter >4.5 cm) of abdominal or pelvic origin were selected and used for clinical study of computed tomography (CT)/magnetic resonance imaging (MRI) dual-modality abdominal tumors. In the test, average particle size of Gd-Au DENPs-FA nanoparticles was 4.2 nm, and they had good water solubility and stability in aqueous solution. When concentration of Au+ nanoparticles increased, the cell morphology remained normal, only a small number of round cells appeared, and the cell activity remained above 80%. GD-Au DENPs-FA nanoparticles had a good targeting specificity for KB cells with high folate receptor expression. During 6–24 hours of injection, the signal at the tumor site of the patient was enhanced markedly, namely the targeted gold nanoparticles were bound to the tumor tissue and the metabolic rate was slow. Based on this material, CT/MRI imaging could be performed in the patient’s body and further used for the early diagnosis of abdominal tumors.

Cyclic-Arginine-Glycine-Aspartic (c-RGD) Conjugated Polymeric Micelles for SPECT/NIRF Dual-Modality Tumor Imaging

2018 ◽  
Vol 18 (11) ◽  
pp. 7858-7866
Author(s):  
Hua Zhu ◽  
Lei Xia ◽  
Xiaoxia Xu ◽  
Fei Liu ◽  
Jun Zhao ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Tumor Imaging ◽  
Dual Modality
Sign in / Sign up

Export Citation Format

Share Document