Age-related and regional differences in secretin and secretin receptor mRNA levels in the rat brain

2004 ◽  
Vol 366 (2) ◽  
pp. 176-181 ◽  
Author(s):  
Joyce Tay ◽  
Martin Goulet ◽  
James Rusche ◽  
Richard Boismenu
Keyword(s):  
Rat Brain ◽  
Regional Differences ◽  
Mrna Levels ◽  
Receptor Mrna ◽  
Age Related ◽  
Secretin Receptor

Chronic morphine and naltrexone fail to modify μ-opioid receptor mRNA levels in the rat brain

1997 ◽  
Vol 45 (1) ◽  
pp. 149-153 ◽  
Author(s):  
M.Paola Castelli ◽  
Miriam Melis ◽  
Michela Mameli ◽  
Paola Fadda ◽  
Giacomo Diaz ◽  
...  
Keyword(s):  
Rat Brain ◽  
Opioid Receptor ◽  
Mrna Levels ◽  
Chronic Morphine ◽  
Receptor Mrna ◽  
Μ Opioid Receptor

Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6

2006 ◽  
Vol 291 (6) ◽  
pp. F1177-F1183 ◽  
Author(s):  
Monique van Abel ◽  
Sylvie Huybers ◽  
Joost G. J. Hoenderop ◽  
Annemiete W. C. M. van der Kemp ◽  
Johannes P. T. M. van Leeuwen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mrna Levels ◽  
Serum Osteocalcin ◽  
Intestinal Epithelial ◽  
Receptor Mrna ◽  
Age Related ◽  
Age Dependent ◽  
Elder People ◽  
Age Related Changes

Aging is associated with alterations in Ca2+ homeostasis, which predisposes elder people to hyperparathyroidism and osteoporosis. Intestinal Ca2+ absorption decreases with aging and, in particular, active transport of Ca2+ by the duodenum. In addition, there are age-related changes in renal Ca2+ handling. To examine age-related changes in expression of the renal and intestinal epithelial Ca2+ channels, control (TRPV5+/+) and TRPV5 knockout (TRPV5−/−) mice aged 10, 30, and 52 wk were studied. Aging of TRPV5+/+ mice resulted in a tendency toward increased renal Ca2+ excretion and significantly decreased intestinal Ca2+ absorption, which was accompanied by reduced expression of TRPV5 and TRPV6, respectively, despite increased serum 1,25(OH)2D3 levels. Similarly, in TRPV5−/− mice the existing renal Ca2+ loss was more pronounced in elder animals, whereas the compensatory intestinal Ca2+ absorption and TRPV6 expression declined with aging. In both mice strains, aging resulted in a resistance to 1,25(OH)2D3 and diminished renal vitamin D receptor mRNA levels, whereas serum Ca2+ levels remained constant. Furthermore, 52-wk-old TRPV5−/− mice showed severe hyperparathyroidism, whereas PTH levels in elder TRPV5+/+ mice remained normal. In 52-wk-old TRPV5−/− mice, serum osteocalcin levels were increased in accordance with the elevated PTH levels, suggesting an increased bone turnover in these mice. In conclusion, downregulation of TRPV5 and TRPV6 is likely involved in the impaired Ca2+ (re)absorption during aging. Moreover, TRPV5−/− mice likely develop age-related hyperparathyroidism and osteoporotic characteristics before TRPV5+/+ mice, demonstrating the importance of the epithelial Ca2+ channels in Ca2+ homeostasis.

Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA levels in the rat brain

1999 ◽  
Vol 66 (1-2) ◽  
pp. 184-187 ◽  
Author(s):  
Xiao-Min Wang ◽  
Yan Zhou ◽  
Rudolph Spangler ◽  
Ann Ho ◽  
Ji-Shen Han ◽  
...  
Keyword(s):  
Rat Brain ◽  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Mrna Levels ◽  
Kappa Opioid ◽  
Receptor Mrna

Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment

1992 ◽  
Vol 106 (4) ◽  
pp. 479-483 ◽  
Author(s):  
Paul R. Buckland ◽  
Michael C. O'Donovan ◽  
Peter McGuffin
Keyword(s):  
Rat Brain ◽  
Antipsychotic Treatment ◽  
Mrna Levels ◽  
D3 Receptor ◽  
Receptor Mrna

Effects of clozapine and haloperidol on 5-HT6 receptor mRNA levels in rat brain

1999 ◽  
Vol 38 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Jon A. Frederick ◽  
James H. Meador-Woodruff
Keyword(s):  
Rat Brain ◽  
Mrna Levels ◽  
Receptor Mrna

scholarly journals Dynamic Alterations in Growth Hormone Receptor mRNA Levels in Rat Brain During Stress Tolerance.

1996 ◽  
Vol 43 (Suppl) ◽  
pp. S119-S122 ◽  
Author(s):  
TAKAHIKO FUJIKAWA ◽  
HIDEO YOSHIZATO ◽  
HIDEAKI SOYA ◽  
KUNIO NAKASHIMA
Keyword(s):  
Growth Hormone ◽  
Rat Brain ◽  
Stress Tolerance ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Mrna Levels ◽  
Receptor Mrna ◽  
Growth Hormone Receptor Mrna
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